ChemicalBook > CAS DataBase List > Faropenem sodium

Faropenem sodium

Product Name: Faropenem sodium
CAS No.: 122547-49-3
Chemical Name: Faropenem sodium
Synonyms: Faropenem sodium hydrate;alp201;sy5555;ym-044;sun5555;wy49605;Furopenem;fropenumsodium;Sodium faropenem;Faropenem sodium
CBNumber: CB8429283
Molecular Formula: C12H14NO5S.Na
Formula Weight: 307.3
MOL File: 122547-49-3.mol

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Faropenem sodium Property

Melting point:: >85°C (dec.)
alpha: D22 +60° (c = 0.10)
storage temp.: -20°C
solubility: H2O: ≥20mg/mL
form: powder
color: white to light brown
optical activity: [α]/D +120 to +130°, c =1.0 in water
Water Solubility: H2O: ≥20mg/mL
Stability:: Hygroscopic
InChI: InChI=1/C12H15NO5S.Na/c1-5(14)7-10(15)13-8(12(16)17)9(19-11(7)13)6-3-2-4-18-6;/h5-7,11,14H,2-4H2,1H3,(H,16,17);/q;+1/p-1/t5-,6-,7+,11-;/s3
InChIKey: ICSAXRANXQSPQP-WWTPKCCHNA-M
SMILES: N12C([C@]([H])([C@H](O)C)[C@@]1([H])SC([C@@H]1OCCC1)=C2C([O-])=O)=O.[Na+] |&1:2,4,7,11,r|

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: F8182
Product name: Faropenem sodium hydrate
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $86.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: F8182
Product name: Faropenem sodium hydrate
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $350
Updated: 2025/07/31

Usbiological

Product number: F2951
Product name: Faropenem Sodium Salt, Hemipentahydrate
Packaging: 10mg
Price: $425
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002676
Product name: FAROPENEM SODIUM
Purity: 95.00%
Packaging: 1G
Price: $896.23
Updated: 2021/12/16

ChemScene

Product number: CS-M0814
Product name: Faropenemsodium
Purity: 99.26%
Packaging: 5mg
Price: $72
Updated: 2021/12/16

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Faropenem sodium Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Crystals

Uses

Faropenem is an orally active beta-lactam antibiotic belonging to the penem group.

General Description

Faropenem sodium hydrate belongs to the penem group of antibiotics prescribed for oral usage. Enterobacteriaceae bacterial infections with cephalosporin resistance are susceptible to faropenem. Faropenem could be an effective antibiotic to treat urinary tract infections caused by extended-spectrum beta-lactamases (ESBL) producing bacteria.

Biochem/physiol Actions

Faropenem sodium is an ultra-broad spectrum, β-lactamase resistant, β-lactam antibiotic active against both Gram-positive and Gram-negative bacteria.

Synthesis

106559-80-2

122547-49-3

At room temperature, 150 g of Intermediate II was mixed with 1110 mL of dichloromethane and stirred until completely dissolved, followed by the addition of 18 g of triphenylphosphine and an ethyl acetate solution of sodium caprylate (prepared from 92 g of sodium isooctanoate and 1110 mL of ethyl acetate) to give a pale yellow transparent liquid. After displacing the air in the reaction system with nitrogen for 5 minutes, 2.664 g of tetrakis(triphenylphosphine)palladium was added under nitrogen protection. After addition, the reaction temperature was maintained at 25~30°C and stirred continuously under nitrogen protection for 40 minutes. Upon completion of the reaction, 40 g of pure water was added to the reaction solution at room temperature, and crystallization was carried out at a controlled temperature of 20~30 °C for 2 h. The reaction was then cooled to -5~0 °C and stirring was continued for 2 h. The reaction mixture was separated by filtration. The reaction mixture was separated by filtration and the filter cake was washed with 200 mL x 3 of ethyl acetate. Finally, the filter cake was dried under vacuum at 35~40 °C to give 119 g of white powdery product in 73.3% molar yield.

References

[1] Organic Process Research and Development, 2010, vol. 14, # 4, p. 939 - 941
[2] Patent: CN107337684, 2017, A. Location in patent: Paragraph 0052; 0086-0094; 0110-0112
[3] Bioorganic and Medicinal Chemistry, 1997, vol. 5, # 7, p. 1389 - 1399

Faropenem sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Faropenem sodium manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Faropenem Sodium 122547-49-3
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-08

Hebei Ganmiao New material Technology Co., LTD

Product: Faropenem sodium 122547-49-3
Price: US $9.00-5.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 200ton
Release date: 2024-06-19

R&D Scientific Inc.

Product: Faropenem sodium 122547-49-3
Price: US $300.00/g
Min. Order: 1g
Purity: 98
Supply Ability: 500 Kg
Release date: 2024-04-26

122547-49-3, Faropenem sodiumRelated Search:

Sulopenem Ethyl maltol Sodium acetate Diethylstilbestrol Sodium sulfate Faropenem daloxate Diclofenac sodium 2-(METHYLSULFONYL)ETHANOL Sodium chlorite Sodium chloride Sodium benzoate Sodium bicarbonate Sodium citrate Tetrahydrofuran 1-Hydroxyethylidene-1,1-diphosphonic acid Sodium hydroxide α-Lipoic Acid Furazolidone

(5R,6S,8R,2′R)-2-(2′-tetrahydrofuryl)-6-hydroxyethylpenem-3-carboxylate sodium salt

Faropenem sodium hydrate

(5r,6s)-6-(1(r)-hydroxyethyl)-2-(2(r)-tetrahydrofuryl)penem-3-carboxylicacid

6-(1-hydroxyethyl)-7-oxo-3-(tetrahydro-2-furanyl)-,monosodiumsalt,(5r-(3(r*),5-alpha,6-alpha(r*)4-thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylicaci

alp201

fropenumsodium

(5r-(3(r*),5-alpha,6-alpha(r*)))-6-(1-hydroxyethyl)-7-oxo-3-(tetrahydro-2-furanyl)-4-thia-1-azabicyclo(3.2.0) hept-2-ene-2-carboxylic acid monosodium salt

4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-7-oxo-3-(tetrahydro-2-furanyl)-, monosodium salt, [5R-[3(R*),5α,6α(R*)]]-

4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furanyl]-, monosodium salt, (5R,6S)-

Furopenem

Sodium faropenem

Faropenem sodium

sodiuM (5S,6R)-6-((S)-1-hydroxyethyl)-7-oxo-3-((R)-tetrahydrofuran-2-yl)-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

(5R)-6β-[(R)-1-Hydroxyethyl]-3-[(2R)-oxolan-2-yl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid sodium salt

(5R,6S)-6-[(R)-1-Hydroxyethyl]-7-oxo-3-[[(R)-tetrahydrofuran]-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid sodium salt

Suflopenem sodium

Faropenem Sodium Salt

Faropenem-d5 Sodium Salt

sodium (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-(2-oxolanyl)-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

o-3-(tetrahydro-2-furanyl)-,monosodiumsalt,(5r-(3(r*),5-alpha,6-alpha(r*)))

sun5555

sy5555

wy49605

ym-044

(5r-(3(r*),5-alpha,6-alpha(r*)))-6-(1-hydroxyethyl)-7-oxo-3- (tetrahydro-2-furanyl)-4-thia-1-azabicyclo(3.2.0) hept-2-ene-2-carboxylic acid monosodium salt

6-[(1r)-1-hydroxyethyl]-7-oxo-3-[(2r)-tetrahydro-2-furanyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monosodium salt hemipentahydrate

FAROPENEM SODIUM SALT HEMIPENTAHYDRATE

Faropenem Sodium Tablets

Fluconazole Impurity 10(EP Impurity I)

Faropenem sodium USP/EP/BP

Faropenem sodiumQ: What is Faropenem sodium Q: What is the CAS Number of Faropenem sodium Q: What is the storage condition of Faropenem sodium

Faropenem Sodium Hydrate(5/2 H2O)

Sodium (5R,6S)-6-((R)-1-hydroxyethyl)-7-oxo-3-((R)-tetrahydrofuran-2-yl)-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

Faropenem-d7 Sodium Salt

Faropenem sodium, 10 mM in DMSO

Faropenem Sodium: (5R,6S)-6-((R)-1-Hydroxyethyl)-7-oxo-3-((R)-tetrahydrofuran-2-yl)-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, sodium salt

D7-Faropenem Sodium Salt

122547-49-3

C24H28N2Na2O10S25H2O

C24H38N2Na2O15S2

C12H14NNaO5S52H2O

C12H15NNaO5S

C12H15NO5SNa

C12H14NO5SNa

C12H14NO5SNaH2O

Cnbio

Intermediates & Fine Chemicals

Pharmaceuticals

chiral

Pharmaceutical intermediates