Faropenem sodium
- Product Name
- Faropenem sodium
- CAS No.
- 122547-49-3
- Chemical Name
- Faropenem sodium
- Synonyms
- Faropenem sodium hydrate;alp201;sy5555;ym-044;sun5555;wy49605;Furopenem;fropenumsodium;Sodium faropenem;Faropenem sodium
- CBNumber
- CB8429283
- Molecular Formula
- C12H14NO5S.Na
- Formula Weight
- 307.3
- MOL File
- 122547-49-3.mol
Faropenem sodium Property
- Melting point:
- >85°C (dec.)
- alpha
- D22 +60° (c = 0.10)
- storage temp.
- -20°C
- solubility
- H2O: ≥20mg/mL
- form
- powder
- color
- white to light brown
- optical activity
- [α]/D +120 to +130°, c =1.0 in water
- Water Solubility
- H2O: ≥20mg/mL
- Stability:
- Hygroscopic
- InChI
- InChI=1/C12H15NO5S.Na/c1-5(14)7-10(15)13-8(12(16)17)9(19-11(7)13)6-3-2-4-18-6;/h5-7,11,14H,2-4H2,1H3,(H,16,17);/q;+1/p-1/t5-,6-,7+,11-;/s3
- InChIKey
- ICSAXRANXQSPQP-WWTPKCCHNA-M
- SMILES
- N12C([C@]([H])([C@H](O)C)[C@@]1([H])SC([C@@H]1OCCC1)=C2C([O-])=O)=O.[Na+] |&1:2,4,7,11,r|
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- F8182
- Product name
- Faropenem sodium hydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $86.5
- Updated
- 2025/07/31
- Product number
- F8182
- Product name
- Faropenem sodium hydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $350
- Updated
- 2025/07/31
- Product number
- F2951
- Product name
- Faropenem Sodium Salt, Hemipentahydrate
- Packaging
- 10mg
- Price
- $425
- Updated
- 2021/12/16
- Product number
- API0002676
- Product name
- FAROPENEM SODIUM
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $896.23
- Updated
- 2021/12/16
- Product number
- CS-M0814
- Product name
- Faropenemsodium
- Purity
- 99.26%
- Packaging
- 5mg
- Price
- $72
- Updated
- 2021/12/16
Faropenem sodium Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Crystals
Uses
Faropenem is an orally active beta-lactam antibiotic belonging to the penem group.
General Description
Faropenem sodium hydrate belongs to the penem group of antibiotics prescribed for oral usage. Enterobacteriaceae bacterial infections with cephalosporin resistance are susceptible to faropenem. Faropenem could be an effective antibiotic to treat urinary tract infections caused by extended-spectrum beta-lactamases (ESBL) producing bacteria.
Biochem/physiol Actions
Faropenem sodium is an ultra-broad spectrum, β-lactamase resistant, β-lactam antibiotic active against both Gram-positive and Gram-negative bacteria.
Synthesis
106559-80-2
122547-49-3
At room temperature, 150 g of Intermediate II was mixed with 1110 mL of dichloromethane and stirred until completely dissolved, followed by the addition of 18 g of triphenylphosphine and an ethyl acetate solution of sodium caprylate (prepared from 92 g of sodium isooctanoate and 1110 mL of ethyl acetate) to give a pale yellow transparent liquid. After displacing the air in the reaction system with nitrogen for 5 minutes, 2.664 g of tetrakis(triphenylphosphine)palladium was added under nitrogen protection. After addition, the reaction temperature was maintained at 25~30°C and stirred continuously under nitrogen protection for 40 minutes. Upon completion of the reaction, 40 g of pure water was added to the reaction solution at room temperature, and crystallization was carried out at a controlled temperature of 20~30 °C for 2 h. The reaction was then cooled to -5~0 °C and stirring was continued for 2 h. The reaction mixture was separated by filtration. The reaction mixture was separated by filtration and the filter cake was washed with 200 mL x 3 of ethyl acetate. Finally, the filter cake was dried under vacuum at 35~40 °C to give 119 g of white powdery product in 73.3% molar yield.
References
[1] Organic Process Research and Development, 2010, vol. 14, # 4, p. 939 - 941
[2] Patent: CN107337684, 2017, A. Location in patent: Paragraph 0052; 0086-0094; 0110-0112
[3] Bioorganic and Medicinal Chemistry, 1997, vol. 5, # 7, p. 1389 - 1399
Faropenem sodium Preparation Products And Raw materials
Raw materials
Preparation Products
Faropenem sodium Suppliers
- Tel
- --
- Fax
- --
- info@aschem.ch
- Country
- Switzerland
- ProdList
- 897
- Advantage
- 58
View Lastest Price from Faropenem sodium manufacturers
- Product
- Faropenem Sodium 122547-49-3
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-08
- Product
- Faropenem sodium 122547-49-3
- Price
- US $9.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 200ton
- Release date
- 2024-06-19
- Product
- Faropenem sodium 122547-49-3
- Price
- US $300.00/g
- Min. Order
- 1g
- Purity
- 98
- Supply Ability
- 500 Kg
- Release date
- 2024-04-26