4-CHLORO-2-ANISIDINE HYDROCHLORIDE
- Product Name
- 4-CHLORO-2-ANISIDINE HYDROCHLORIDE
- CAS No.
- 93-50-5
- Chemical Name
- 4-CHLORO-2-ANISIDINE HYDROCHLORIDE
- Synonyms
- 4-CHLORO-O-ANISIDINE;p-Chloro-o-anisidine;2-Amino-5-chloroanisole;2-Methoxy-4-chloroaniline;4-Chloro-2-methoxyaniline;4-Chloro-o-anisidine (NH2=1);4-Chloro-2-methoxyaniline 98%;4-chloro-2-methoxy-benzenamin;4-chloro-2-methoxybenzenamine;4-Chloro-2-methoxybenzeneamine
- CBNumber
- CB8435071
- Molecular Formula
- C7H8ClNO
- Formula Weight
- 157.6
- MOL File
- 93-50-5.mol
4-CHLORO-2-ANISIDINE HYDROCHLORIDE Property
- Melting point:
- 52°C
- Boiling point:
- 260°C (rough estimate)
- Density
- 1.1760 (rough estimate)
- refractive index
- 1.5430 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 3.90±0.10(Predicted)
- form
- Solid
- color
- Dark Brown
- CAS DataBase Reference
- 93-50-5(CAS DataBase Reference)
- EPA Substance Registry System
- Benzenamine, 4-chloro-2-methoxy- (93-50-5)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 006360
- Product name
- 4-Chloro-2-methoxyaniline
- Packaging
- 250mg
- Price
- $446
- Updated
- 2021/12/16
- Product number
- C367820
- Product name
- 4-Chloro-2-methoxyaniline
- Packaging
- 1g
- Price
- $465
- Updated
- 2021/12/16
- Product number
- OR11504
- Product name
- 4-Chloro-2-methoxyaniline
- Purity
- 98%
- Packaging
- 1g
- Price
- $56
- Updated
- 2021/12/16
- Product number
- FC20021
- Product name
- 4-Chloro-2-methoxyaniline
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 4656-5-U6
- Product name
- 4-Chloro-2-methoxyaniline
- Purity
- 98%
- Packaging
- 1g
- Price
- $61
- Updated
- 2021/12/16
4-CHLORO-2-ANISIDINE HYDROCHLORIDE Chemical Properties,Usage,Production
Chemical Properties
Dark Brown Low Melting Solid
Uses
4-Chloro-2-methoxyaniline is an important intermediate used for the synthesis of CXCR2 antagonists and some CD4-gp120 binding inhibitors.
Synthesis
6627-53-8
93-50-5
General procedure: Make a suspension of iron powder (5.0 eq.), ammonium chloride (0.65 eq.) and distilled water and reflux for 15 minutes. 2-Nitro-5-chloroanisole (1.0 eq.) was added slowly and the reaction mixture continued to be stirred under reflux conditions. The progress of the reaction was monitored by thin layer chromatography (TLC) and when the reaction was complete, the reaction mixture was neutralized by slow dropwise addition of 5% aqueous sodium bicarbonate, followed by filtration through diatomaceous earth. The filtrate was extracted three times with ethyl acetate. The organic phases were combined and washed once each with saturated saline and 5% aqueous hydrochloric acid, in that order. The aqueous phases were combined, the pH was adjusted to neutral with 20% aqueous sodium hydroxide, and then extracted three times with ethyl acetate. The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The product can be purified by mixed solvent column chromatography with ethyl acetate/hexane or used directly as a crude product. Product purity was confirmed by 1H-NMR. Example 1: The crude 4-chloro-2-methoxyaniline was obtained as a dark purple oil (1.15 g, 91% yield) from the reaction of iron powder (2.23 g, 40 mmol), ammonium chloride (278 mg, 5.2 mmol), water (48 mL), and 5-chloro-2-nitroanisole (1.5 g, 8.0 mmol) for 1.5 h. The reaction was carried out by 1H NMR ( 300MHz, CDCl3): δ 6.78 (m, 2H), 6.65 (d, 1H), 3.86 (s, 3H). Example 2: 4-Chloro-2-methoxyaniline crude was obtained as a dark purple oil (2.35 g, 93% yield) after reacting for 2 hours with iron powder (4.47 g, 80.0 mmol), ammonium chloride (556 mg, 10.4 mmol), water (80 mL) and 5-chloro-2-nitroanisole (3.0 g, 16.0 mmol). No 1H-NMR analysis was performed.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 14, p. 3864 - 3867
[2] ChemMedChem, 2014, vol. 9, # 5, p. 962 - 972
[3] Patent: WO2006/71730, 2006, A1. Location in patent: Page/Page column 79; 80
[4] Patent: WO2014/28805, 2014, A1. Location in patent: Page/Page column 65
[5] Patent: WO2004/37789, 2004, A2. Location in patent: Page 312
4-CHLORO-2-ANISIDINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-CHLORO-2-ANISIDINE HYDROCHLORIDE manufacturers
- Product
- 4-Chloro-2-Methoxyaniline 93-50-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-25
- Product
- 4-CHLORO-2-ANISIDINE HYDROCHLORIDE 93-50-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000KG
- Release date
- 2024-08-09
- Product
- 4-CHLORO-2-ANISIDINE HYDROCHLORIDE 93-50-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg; 2kg；10kg; 100kg
- Release date
- 2019-08-30