ChemicalBook > CAS DataBase List > 4-CHLORO-2-ANISIDINE HYDROCHLORIDE

4-CHLORO-2-ANISIDINE HYDROCHLORIDE

Product Name: 4-CHLORO-2-ANISIDINE HYDROCHLORIDE
CAS No.: 93-50-5
Chemical Name: 4-CHLORO-2-ANISIDINE HYDROCHLORIDE
Synonyms: 4-CHLORO-O-ANISIDINE;p-Chloro-o-anisidine;2-Amino-5-chloroanisole;2-Methoxy-4-chloroaniline;4-Chloro-2-methoxyaniline;4-Chloro-o-anisidine (NH2=1);4-Chloro-2-methoxyaniline 98%;4-chloro-2-methoxy-benzenamin;4-chloro-2-methoxybenzenamine;4-Chloro-2-methoxybenzeneamine
CBNumber: CB8435071
Molecular Formula: C7H8ClNO
Formula Weight: 157.6
MOL File: 93-50-5.mol

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4-CHLORO-2-ANISIDINE HYDROCHLORIDE Property

Melting point:: 52°C
Boiling point:: 260°C (rough estimate)
Density: 1.1760 (rough estimate)
refractive index: 1.5430 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 3.90±0.10(Predicted)
form: Solid
color: Dark Brown
CAS DataBase Reference: 93-50-5(CAS DataBase Reference)
EPA Substance Registry System: Benzenamine, 4-chloro-2-methoxy- (93-50-5)

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Safety

Hazard Codes: Xi
Risk Statements: 43
Safety Statements: 36/37
Hazard Note: Irritant/Keep Cold
HS Code: 2921420090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Usbiological

Product number: 006360
Product name: 4-Chloro-2-methoxyaniline
Packaging: 250mg
Price: $446
Updated: 2021/12/16

TRC

Product number: C367820
Product name: 4-Chloro-2-methoxyaniline
Packaging: 1g
Price: $465
Updated: 2021/12/16

Apolloscientific

Product number: OR11504
Product name: 4-Chloro-2-methoxyaniline
Purity: 98%
Packaging: 1g
Price: $56
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20021
Product name: 4-Chloro-2-methoxyaniline
Packaging: 250mg
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4656-5-U6
Product name: 4-Chloro-2-methoxyaniline
Purity: 98%
Packaging: 1g
Price: $61
Updated: 2021/12/16

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4-CHLORO-2-ANISIDINE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Dark Brown Low Melting Solid

Uses

4-Chloro-2-methoxyaniline is an important intermediate used for the synthesis of CXCR2 antagonists and some CD4-gp120 binding inhibitors.

Synthesis

6627-53-8

93-50-5

General procedure: Make a suspension of iron powder (5.0 eq.), ammonium chloride (0.65 eq.) and distilled water and reflux for 15 minutes. 2-Nitro-5-chloroanisole (1.0 eq.) was added slowly and the reaction mixture continued to be stirred under reflux conditions. The progress of the reaction was monitored by thin layer chromatography (TLC) and when the reaction was complete, the reaction mixture was neutralized by slow dropwise addition of 5% aqueous sodium bicarbonate, followed by filtration through diatomaceous earth. The filtrate was extracted three times with ethyl acetate. The organic phases were combined and washed once each with saturated saline and 5% aqueous hydrochloric acid, in that order. The aqueous phases were combined, the pH was adjusted to neutral with 20% aqueous sodium hydroxide, and then extracted three times with ethyl acetate. The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The product can be purified by mixed solvent column chromatography with ethyl acetate/hexane or used directly as a crude product. Product purity was confirmed by 1H-NMR. Example 1: The crude 4-chloro-2-methoxyaniline was obtained as a dark purple oil (1.15 g, 91% yield) from the reaction of iron powder (2.23 g, 40 mmol), ammonium chloride (278 mg, 5.2 mmol), water (48 mL), and 5-chloro-2-nitroanisole (1.5 g, 8.0 mmol) for 1.5 h. The reaction was carried out by 1H NMR ( 300MHz, CDCl3): δ 6.78 (m, 2H), 6.65 (d, 1H), 3.86 (s, 3H). Example 2: 4-Chloro-2-methoxyaniline crude was obtained as a dark purple oil (2.35 g, 93% yield) after reacting for 2 hours with iron powder (4.47 g, 80.0 mmol), ammonium chloride (556 mg, 10.4 mmol), water (80 mL) and 5-chloro-2-nitroanisole (3.0 g, 16.0 mmol). No 1H-NMR analysis was performed.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 14, p. 3864 - 3867
[2] ChemMedChem, 2014, vol. 9, # 5, p. 962 - 972
[3] Patent: WO2006/71730, 2006, A1. Location in patent: Page/Page column 79; 80
[4] Patent: WO2014/28805, 2014, A1. Location in patent: Page/Page column 65
[5] Patent: WO2004/37789, 2004, A2. Location in patent: Page 312

4-CHLORO-2-ANISIDINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-2-ANISIDINE HYDROCHLORIDE Suppliers

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View Lastest Price from 4-CHLORO-2-ANISIDINE HYDROCHLORIDE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-Chloro-2-Methoxyaniline 93-50-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-25

Shaanxi Dideu Medichem Co. Ltd

Product: 4-CHLORO-2-ANISIDINE HYDROCHLORIDE 93-50-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000KG
Release date: 2024-08-09

Career Henan Chemical Co

Product: 4-CHLORO-2-ANISIDINE HYDROCHLORIDE 93-50-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg; 2kg；10kg; 100kg
Release date: 2019-08-30

93-50-5, 4-CHLORO-2-ANISIDINE HYDROCHLORIDERelated Search:

4-CHLORO-2-ANISIDINE HYDROCHLORIDE 1-Chloro-2,5-dimethoxy-4-nitrobenzene 5-CHLORO-2-NITROANISOLE 4-Chloro-2-methoxy-N-methylaniline 96% 2,5-Dimethoxy-4-chloroaniline 4'-Chloro-2',5'-dimethoxyacetoacetanilide NAPHTHOL AS-LC ACETATE 4-Chloro-2-methoxy-5-methylaniline 1-CHLORO-2,5-DIETHOXY-4-NITROBENZENE 6-CHLORO-M-ANISIDINE HYDROCHLORIDE,6-CHLORO-META-ANISIDINE HYDROCHLORIDE, 9 6%,6-Chloro-meta-anisidine hydrochloride 98% 5-chloro-o-anisidine hydrochloride 6-chloro-meta-anisidine hydrochloride O-ANISIDINE HYDROCHLORIDE o-Anisidine 2-CHLORO-N-(4-CHLORO-2,5-DIMETHOXYPHENYL)ACETAMIDE N-(4-CHLORO-6-METHOXYPHENYL)-2,2-DIMETHYLPROPANAMIDE 6-chloro-3-(chloromethyl)benzoxazol-2(3H)-one 5,6-DICHLOROBENZOXAZOLINONE

4-Chloro-2-methoxyaniline 98%

4-Chloro-o-anisidine (NH2=1)

1-Amino-4-chloro-2-methoxybenzene

(4-chloro-2-methoxy-phenyl)amine

2-Methoxy-4-chloroaniline

4-Chloro-2-Methoxyaniline hydrochloride

Benzenamine, 4-chloro-2-methoxy-

4-chloro-2-methoxy-benzenamin

4-CHLORO-O-ANISIDINE

4-CHLORO-O-ANISIDINE HYDROCHLORIDE

4-CHLORO-2-ANISIDINE HYDROCHLORIDE

4-CHLORO-2-METHOXY-PHENYLAMINE HYDROCHLORIDE

4-CHLORO-2-METHOXYBENZENAMINE HYDROCHLORIDE

p-Chloro-o-anisidine

2-Amino-5-chloroanisole

4-Chloro-2-methoxyaniline

4-chloro-2-methoxybenzenamine

2-Amino-4-chloro-1-methoxybenzene

4-Chloro-2-methoxybenzeneamine

2-AMINO-5-CHLOROANISOLE HYDROCHLORIDE

93-50-5

C7H8CINOHCl

Amines

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Aromatics

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