NEORUSCOGENIN

Product Name: NEORUSCOGENIN
CAS No.: 17676-33-4
Chemical Name: NEORUSCOGENIN
Synonyms: NEORUSCOGENIN;Einecs 241-660-1;Neoruscogenin-RM;spirost-5,25(27)-dien-1β,3β-diol;spirost-5,25(27)-dien-1β,3β-diol;SPIROSTA-5,25(27)-DIENE-1B,3B-DIOL;Spirosta-5,25(27)-diene-1β,3β-diol;spirosta-5,25(27)-diene-1beta,3beta-diol;Spirosta-5,25(27)-diene-1,3-diol,(1b,3b)-;Spirosta-5,25(27)-diene-1,3-diol, (1β,3β)-
CBNumber: CB8440721
Molecular Formula: C27H40O4
Formula Weight: 428.61
MOL File: 17676-33-4.mol

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NEORUSCOGENIN Property

Melting point:: 196～198℃
Density: 1.19±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: 4°C, protect from light
solubility: ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
form: crystalline solid
Boiling point:: 566.6±50.0 °C(Predicted)
pka: 14.55±0.70(Predicted)
color: White to off-white
LogP: 4.210 (est)

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Safety

HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15567
Product name: Neoruscogenin
Purity: ≥95%
Packaging: 1mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 15567
Product name: Neoruscogenin
Purity: ≥95%
Packaging: 5mg
Price: $477
Updated: 2024/03/01

Cayman Chemical

Product number: 15567
Product name: Neoruscogenin
Purity: ≥95%
Packaging: 10mg
Price: $834
Updated: 2024/03/01

Usbiological

Product number: 285002
Product name: Neoruscogenin
Packaging: 5mg
Price: $333
Updated: 2021/12/16

TRC

Product number: N390150
Product name: Neoruscogenin
Packaging: 5mg
Price: $360
Updated: 2021/12/16

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NEORUSCOGENIN Chemical Properties,Usage,Production

Uses

Neoruscogenin is a natural sapogenin isolated from Butcher’s broom (R. rhizoma), which is traditionally used against chronic venous disorders.

Biological Activity

neoruscogenin is a bioavailable, potent, and high-affinity agonist of the nuclear receptor rorα [1]. neoruscogenin is a natural sapogenin extracted from butcher’s broom (rusci rhizoma, ruscus aculeatus, ruscaceae) [2].rar-related orphan receptor alpha (rorα) is a nuclear receptor that participates in the transcriptional regulation of some genes involved incircadian rhythm. genetic studies have revealed that rorα plays an important role in the development of the central nervous system and has been associated with genetic lesions in mice [3].

in vitro

in confluent human microvascular endothelial cells (hmec-1), pre-treatment with neoruscogenin slightly decreased the permeability at concentrations up to 100 μm (71.8%). the ec50 of neoruscogenin against the nuclear receptor rorα was 110 nm [1].

in vivo

in mice, oral administration of neoruscogenin (3 mg/kg/d) for seven days up-regulated the expression of several rorα-inducible genes in the liver [1].

References

[1] helleboid s, haug c, lamottke k, et al. the identification of naturally occurring neoruscogenin as a bioavailable, potent, and high-affinity agonist of the nuclear receptor rorα (nr1f1)[j]. journal of biomolecular screening, 2013: 1087057113497095.
[2] barbi m, willer e a, rothenhfer m, et al. spirostanol saponins and esculin from rusci rhizoma reduce the thrombin-induced hyperpermeability of endothelial cells[j]. phytochemistry, 2013, 90: 106-113.
[3] giguère v. orphan nuclear receptors: from gene to function 1[j]. endocrine reviews, 1999, 20(5): 689-725.

NEORUSCOGENIN Preparation Products And Raw materials

Raw materials

Preparation Products

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NEORUSCOGENIN Suppliers

China 112 Germany 3 India 1 Switzerland 1 United Kingdom 5 United States 17 Global 139

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View Lastest Price from NEORUSCOGENIN manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Neoruscogenin 17676-33-4
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-04-26

Career Henan Chemical Co

Product: NEORUSCOGENIN 17676-33-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 25kg
Release date: 2019-07-12

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Spirosta-5,25(27)-diene-1,3-diol,(1b,3b)-

SPIROSTA-5,25(27)-DIENE-1B,3B-DIOL

NEORUSCOGENIN

spirosta-5,25(27)-diene-1beta,3beta-diol

Spirosta-5,25(27)-diene-1β,3β-diol

Einecs 241-660-1

Spirosta-5,25(27)-diene-1,3-diol, (1.beta.,3.beta.)-

Neoruscogenin, 98%, from Ophiopogon japonicus (Linn. f.) Ker-Gawl.

Spirosta-5,25(27)-diene-1,3-diol, (1β,3β)-

spirost-5,25(27)-dien-1β,3β-diol

(4R,6R,6aR,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-6a,8a,9-Trimethyl-5'-methylene-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4,6-diol

Neoruscogenin-RM

17676-33-4

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