ChemicalBook > CAS DataBase List > KN-62
KN-62
- Product Name
- KN-62
- CAS No.
- 127191-97-3
- Chemical Name
- KN-62
- Synonyms
- KN-2;N 62;KN-62;CS-756;KN-62 97%;KN-62,97%;KN 62;KN-2;KN-62, 99+%;KN 62; KN62;KN-62, >=98%
- CBNumber
- CB8443368
- Molecular Formula
- C38H35N5O6S2
- Formula Weight
- 721.84
- MOL File
- 127191-97-3.mol
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KN-62 Property
- Melting point:
- 92-94°C
- Boiling point:
- 964.7±75.0 °C(Predicted)
- Density
- 1.388
- storage temp.
- -20°C
- solubility
- 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL
- form
- solid
- pka
- 4.07±0.13(Predicted)
- color
- white
- CAS DataBase Reference
- 127191-97-3(CAS DataBase Reference)
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Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- HS Code
- 29339980
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- I2142
- Product name
- KN-62
- Purity
- ≥95%, powder
- Packaging
- .5mg
- Price
- $132
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 422706
- Product name
- KN-62
- Packaging
- 1mg
- Price
- $181
- Updated
- 2023/01/07
Alfa Aesar
- Product number
- J62444
- Product name
- KN-62
- Packaging
- 1mg
- Price
- $103.65
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- J62444
- Product name
- KN-62
- Packaging
- 10mg
- Price
- $604.65
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 13318
- Product name
- KN-62
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
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KN-62 Chemical Properties,Usage,Production
Chemical Properties
Yellow Solid
Uses
A specific inhibitor of Ca2+/Calmodulin-dependent protein kinase II
Uses
selectively inhibits rat brain Ca2+/cadmodulin-dependent protein kinase II,
Uses
It is used as a potent and selective inhibitor of CaMKII. KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII; Ki=0.9 ?M) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 ?M of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).
Definition
ChEBI: 5-isoquinolinesulfonic acid [4-[(2S)-2-[5-isoquinolinylsulfonyl(methyl)amino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl] ester is a member of piperazines.
General Description
A cell-permeable, reversible, and selective inhibitor of CaM kinase II (Ki = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner.
Biological Activity
Selective, cell-permeable inhibitor of CaM kinase II (IC 50 = 0.9 μ M). Binds directly to the calmodulin binding site of the enzyme. Potent non-competitive antagonist at the P2X 7 receptor (IC 50 = 15 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ .
Biochem/physiol Actions
Selectively inhibits rat brain Ca2+/calmodulin-dependent protein kinase II.
storage
-20°C (desiccate)
KN-62 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from KN-62 manufacturers
Career Henan Chemical Co
- Product
- KN-62 127191-97-3
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-29
127191-97-3, KN-62Related Search:
N-Aminoethylpiperazine
1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDE
1-(3-PHENYLPROPYL)PIPERAZINE
5-Isoquinolinesulfonic acid
1-Acetylpiperazine
4-Methyl-1-piperazineethanamine
1-Piperazineethanamine,N,4-dimethyl-(9CI)
1-(4-phenylpiperazin-1-yl)propan-2-amine
1-(4-PHENYLPIPERAZIN-1-YL)ETHANONE
1-ETHYL-4-PHENYLPIPERAZINE
N-[2-(4-HYDROXYPHENYL)ETHYL]-METHANESULFONAMIDE
2-(4-PHENYLPIPERAZIN-1-YL)ETHANAMINE
KN-62
N-phenethylmethanesulphonamide
1-(PROPANOYL)-PIPERAZINE
KN-62 **NOT FOR SALE IN JAPAN**
KN-62: HBC COMPLEX