ChemicalBook > CAS DataBase List > 8-HYDROXYJULOLIDINE

8-HYDROXYJULOLIDINE

Product Name: 8-HYDROXYJULOLIDINE
CAS No.: 41175-50-2
Chemical Name: 8-HYDROXYJULOLIDINE
Synonyms: 2,3,6,7-TETRAHYDRO-1H,5H-PYRIDO[3,2,1-IJ]QUINOLIN-8-OL;8-HJ;AKOS BBS-00000819;8-HYDROXYJULOLIDINE;TIMTEC-BB SBB006615;8-HydroxyIulolidineHCl;8-Hydroxyjulolidine>8-Hydroxyjulolidine,98%;8-HYDROXYJULOLIDINE HYDROCHLORIDE;2,3,6,7-TETRAHYDRO-1H,5H-BENZO[I,J]-QUIN
CBNumber: CB8445281
Molecular Formula: C12H15NO
Formula Weight: 189.25
MOL File: 41175-50-2.mol

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8-HYDROXYJULOLIDINE Property

Melting point:: 132-134 °C(lit.)
Boiling point:: 374.4±41.0 °C(Predicted)
Density: 1.22±0.1 g/cm3(Predicted)
storage temp.: room temp
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 11.25±0.20(Predicted)
form: Solid
color: White to Pink
Water Solubility: Soluble in water (partly), ethanol, chloroform, methanol, and acetone.
BRN: 1530423
InChI: InChI=1S/C12H15NO/c14-11-6-5-9-3-1-7-13-8-2-4-10(11)12(9)13/h5-6,14H,1-4,7-8H2
InChIKey: FOFUWJNBAQJABO-UHFFFAOYSA-N
SMILES: C12=CC=C(O)C3=C1N(CCC3)CCC2
CAS DataBase Reference: 41175-50-2(CAS DataBase Reference)
EPA Substance Registry System: 1H,5H-Benzo[ij]quinolizin-8-ol, 2,3,6,7-tetrahydro- (41175-50-2)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-37/39-26-36
WGK Germany: 3
F: 10
TSCA: Yes
HS Code: 2933 99 80

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 249394
Product name: 8-Hydroxyjulolidine
Purity: 97%
Packaging: 1g
Price: $107
Updated: 2025/07/31

Sigma-Aldrich

Product number: 249394
Product name: 8-Hydroxyjulolidine
Purity: 97%
Packaging: 5g
Price: $348.65
Updated: 2025/07/31

TCI Chemical

Product number: H0928
Product name: 8-Hydroxyjulolidine
Purity: >97.0%(HPLC)(T)
Packaging: 1g
Price: $55
Updated: 2025/07/31

TCI Chemical

Product number: H0928
Product name: 8-Hydroxyjulolidine
Purity: >97.0%(HPLC)(T)
Packaging: 5g
Price: $187
Updated: 2025/07/31

TRC

Product number: H943675
Product name: 8-Hydroxyjulolidine
Packaging: 250mg
Price: $145
Updated: 2021/12/16

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8-HYDROXYJULOLIDINE Chemical Properties,Usage,Production

Chemical Properties

pink to beige or brown fine crystalline powder

Uses

8-Hydroxyjulolidine is used as an intermediate in the preparation of aminocoumarins via microwave-accelerated Pechmann reaction. It is also employed as a starting material for coumarin C-ribosides.

Uses

8-Hydroxyjulolidine has been used in the electrochemical switching fluorescence study.

General Description

The carboxaldehyde derivative of 8-hydroxyjulolidine is useful as a chromophore in fluorescence chemosensor and chemosensors.

Synthesis

63468-83-7

41175-50-2

The general procedure for the synthesis of 1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-8-ol from 8-methoxyjulolidine was as follows: 8-methoxyjulolidine (10 g, 50 mmol) was dissolved in a mixed solution consisting of 50 mL of 47% hydriodic acid, 80 mL of concentrated hydrochloric acid and 200 mL of water. The reaction mixture was heated to reflux and the progress of the reaction was monitored by thin layer chromatography (TLC). After 15 hours of reaction, 50 mL of concentrated hydrochloric acid was added to the mixture. The total reaction time was 60 hours. Upon completion of the reaction, the solution was cooled in an ice bath and first neutralized to pH 6 with 50% sodium hydroxide solution, followed by the addition of phosphate buffer (prepared by dissolving 6.9 g NaH2PO4-H2O and 1.4 g Na2HPO4 in 100 mL of water). The product was extracted with dichloromethane and the organic phase was washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The resulting crude product was redissolved in dichloromethane and extracted repeatedly with 10% sodium hydroxide solution until the aqueous phase was colorless. Subsequently, the organic phase was acidified, dried and extracted again, and the solvent was removed as described above, resulting in the product 1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-8-ol (6.24 g) in 67% yield and with a melting point of 126-130°C. The product was extracted with sodium sulfate under reduced pressure.

References

[1] Journal of Organic Chemistry, 1987, vol. 52, # 8, p. 1465 - 1468
[2] Journal of Fluorescence, 2015, vol. 25, # 6, p. 1615 - 1628
[3] Chemical Communications, 2011, vol. 47, # 47, p. 12691 - 12693
[4] Chemistry - A European Journal, 2014, vol. 20, # 12, p. 3510 - 3519
[5] Patent: US2018/280543, 2018, A1. Location in patent: Paragraph 0041; 0098

8-HYDROXYJULOLIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 8-HYDROXYJULOLIDINE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 8-HYDROXYJULOLIDINE 41175-50-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: kgs
Release date: 2024-11-18

Shaanxi Dideu Medichem Co. Ltd

Product: 8-HYDROXYJULOLIDINE 41175-50-2
Price: US $0.10/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10
Release date: 2024-08-04

Henan Fengda Chemical Co., Ltd

Product: 8-Hydroxyjulolidine 41175-50-2
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

41175-50-2, 8-HYDROXYJULOLIDINERelated Search:

Coumarin 343 Coumarin 334 Coumarin 314 Coumarin 106 Coumarin 314T 8-HYDROXYJULOLIDINE Coumarin 337 9-Formyl-8-hydroxy-1,1,7,7-tetramethyljulolidine Coumarin 338 Coumarin 153 Coumarin 102 SULFORHODAMINE 101 Julolidine CHROMATIDE(TM) TEXAS RED(R)-5-DUTP SULFORHODAMINE 101 ACID CHLORIDE 10-OXO-2,3,5,6-TETRAHYDRO-1H,4H,10H-11-OXA-3A-AZA-BENZO[DE]ANTHRACENE-9-CARBALDEHYDE 8-HYDROXYJULOLIDINE-9-ALDEHYDE,8-HYDROXYJULOLIDINE-9-CARBOXALDEHYDE,9-FORMYL-8-HYDROXYJULOLIDINE 2,3,5,6-1H,4H-TETRAHYDROQUINOLIZINO[9,9A,1-GH]COUMARIN

2,3,6,7-Tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-8-ol 97%

AKOS BBS-00000819

8-HYDROXY-2,3,6,7-TETRAHYDRO-1H,5H-BENZO[IJ]QUINOLIZINE

8-HYDROXYJULOLIDINE

8-HYDROXYJULOLIDINE HYDROCHLORIDE

2,3,6,7-TETRAHYDRO-1H,5H-BENZO[IJ]QUINOLIZIN-8-OL

2,3,6,7-TETRAHYDRO-1H,5H-PYRIDO[3,2,1-IJ]QUINOLIN-8-OL

8-HydroxyIulolidineHCl

1H,5H-Benzoijquinolizin-8-ol, 2,3,6,7-tetrahydro-

8-Hydroxyjulolidine,98%

2,3,6,7-TETRAHYDRO-1H,5H-BENZO[I,J]-QUIN

1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol

2,3,6,7-Tetrahydro-1H,5H-benzo[i,j]-quinolizin-8-ol for synthesis

2,3,6,7-Tetrahydro-1H,5H-benzop[ij]quinolizine-8-ol

TIMTEC-BB SBB006615

,3,6,7-Tetrahydro-1H,5H-benzo(ij)quinolizin-8-ol

,3,6,7-Tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-8-ol

5h-benzo[ij]quinolizin-8-ol,2,3,6,7-tetrahydro-1

8-Hydroxyjulolidine&gt

1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quin

1-azatricyclo[7.3.1.0?13]trideca-5(13),6,8-trien-6-ol

1-azatricyclo7.3.1.0^{5,13}trideca-5,7,9(13)-trien-6-ol

8-HJ

41175-50-2

ALCOHOL

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Oxygen Compounds

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