ChemicalBook > CAS DataBase List > Fisetin

Fisetin

Product Name
Fisetin
CAS No.
528-48-3
Chemical Name
Fisetin
Synonyms
Fisetine;Fisetin Powder;2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-chroMen-4-one;fisetholz;superfustel;Fisetin Extract;5-desoxyquercetin;ungarischesgelbholz;Cotinus coggygria extract;viset
CBNumber
CB8451569
Molecular Formula
C15H10O6
Formula Weight
286.24
MOL File
528-48-3.mol
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Fisetin Property

Melting point:
>330 °C(lit.)
Boiling point:
348.61°C (rough estimate)
Density 
1.2981 (rough estimate)
refractive index 
1.4413 (estimate)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
Colour Index 
75620
pka
6.83±0.40(Predicted)
color 
Pale Yellow to Very Dark Yellow
Merck 
14,4088
BRN 
292829
Stability:
Hygroscopic
InChI
InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H
InChIKey
XHEFDIBZLJXQHF-UHFFFAOYSA-N
SMILES
C1(C2=CC=C(O)C(O)=C2)OC2=CC(O)=CC=C2C(=O)C=1O
LogP
1.970 (est)
EPA Substance Registry System
Fisetin (528-48-3)
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Safety

Risk Statements 
36/37/38
Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
LK9250000
F 
10
TSCA 
Yes
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL82542
Product name
Fisetin
Purity
phyproof? Reference Substance
Packaging
20MG
Price
$353
Updated
2023/06/20
TCI Chemical
Product number
T0121
Product name
Fisetin
Purity
>96.0%(HPLC)
Packaging
100mg
Price
$32
Updated
2024/03/01
TCI Chemical
Product number
T0121
Product name
Fisetin
Purity
>96.0%(HPLC)
Packaging
1g
Price
$135
Updated
2024/03/01
Alfa Aesar
Product number
L14207
Product name
3,3',4',7-Tetrahydroxyflavone, 96%
Packaging
250mg
Price
$62.65
Updated
2024/03/01
Alfa Aesar
Product number
L14207
Product name
3,3',4',7-Tetrahydroxyflavone, 96%
Packaging
1g
Price
$167.65
Updated
2024/03/01
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Fisetin Chemical Properties,Usage,Production

Description

Fisetin, a well-known plant flavonol from natural flavonoid group, is found in traditional medicines, plants, vegetables, fruits. Fisetin also has anti-oxidant, anti-inflammatory, anti-tumor effects[1].

Chemical Properties

OCHRE POWDER

Uses

Fisetin is used in biological studies as spleen tyrosine kinase inhibitors for autoimmune inflammation disease. This compound has neuroprotective properties.

Definition

ChEBI: Fisetin is a 7-hydroxyflavonol with additional hydroxy groups at positions 3, 3' and 4'. It has a role as an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, an antioxidant, an anti-inflammatory agent, a metabolite, a plant metabolite and a geroprotector. It is a 3'-hydroxyflavonoid, a 7-hydroxyflavonol and a tetrahydroxyflavone. It is a conjugate acid of a fisetin(1-).

Application

Fisetin is primarily used in laboratory bioactivity studies as an analytical standard for qualitative and quantitative analyses of Fisetin, and as a dietary supplement, and sells well for its potential anti-aging and cognitive enhancing effects. Because of its potent antioxidant and anti-inflammatory properties, it has been shown to have varying degrees of inhibitory effects on a wide range of diseases (e.g., cancer, Alzheimer's disease, anti-aging cells, and diabetes), and has been extensively studied in terms of its pharmacological effects in vitro and in vivo.

benefits

Fisetin is known to have antioxidant properties and demonstrates the specific biological activity of protecting functional macromolecules against stress, resulting in a benefit to cellular cytoprotection.It is also known to have anti-inflammatory, chemopreventive, and chemotherapeutic properties.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Mechanism of action

Fisetin has multi-pathway and multi-target properties. Studies have shown that Fisetin can induce p53 activation and cause cell cycle arrest at various checkpoints by activating caspase-8, caspase-9, caspase-3 and inhibiting Bcl-2, leading to apoptosis, and inhibition of NF-κB and ERK1/2 activities, thus inhibiting the survival and growth of tumour cells. In addition, by inhibiting the PI3K/Akt pathway, it also blocks the mTOR pathway and controls feedback loops, as well as preventing oxidative stress, inflammatory responses, and cytotoxicity by modulating the activity of the PI3K/Akt, Nrf2, NF-κB, protein kinase C, and MAPK pathways.

Anticancer Research

Fisetin is a plant polyphenol from the flavonoid group. It occurs in fruits and vegetablesincluding persimmons, strawberries, onions, cucumbers, and apples. It is anantioxidant, exerts anticarcinogenic effects in HCT-116 (human colon carcinoma)cells, and modulates protein kinase and lipid kinase pathways (Wang et al. 2012).Fisetin alter signaling pathway like MAPK, NF-κB, activators of transcription(JAK/STAT), Janus kinase/signal transducers, phosphoinositide-3-kinase-proteinkinase (PI3K/Akt), Wnt, and mammalian target of rapamycin (mTOR), therebyleading to cell cycle arrest in HL-60 cells (human acute promyelocytic leukemiacells) (Singh et al. 2016b). Thus, it exhibits inhibitory effects on adhesion, migration,invasion, and multidrug resistance (Suh et al. 2009).

Side effects

Fisetin is generally considered safe and no significant toxicity has been reported in humans when consumed in dietary amounts. However, as with any dietary supplement or medication, excessive intake of laccasein supplements may result in adverse reactions. Some of the potential adverse effects of laccasein supplementation may include gastrointestinal disturbances such as nausea, vomiting, and diarrhoea. In addition, fisetin may interact with certain medications, such as blood thinners, and may increase the risk of bleeding. fisetin may also have estrogenic activity, which means that it may interact with the body's endocrine system and affect individuals with hormone-sensitive diseases (e.g., breast cancer); therefore, it is important to take precautions before taking fisetin supplements, especially for individuals with a history of hormone-related medical conditions or who are taking medications that may interact with fisetin.

Source

Fisetin is a plant flavonol from the flavonoid group of polyphenols. It can be found in many plants, where it serves as a yellow/ochre colouring agent. It is also found in many fruits and vegetables, such as strawberries, apples, persimmons, onions and cucumbers.

storage

Store at -20°C

References

[1] KIM T W. Fisetin, an Anti-Inflammatory Agent, Overcomes Radioresistance by Activating the PERK-ATF4-CHOP Axis in Liver Cancer.[J]. International Journal of Molecular Sciences, 2023, 24 10. DOI:10.3390/ijms24109076.

Fisetin Preparation Products And Raw materials

Raw materials

Preparation Products

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Fisetin Suppliers

Belgium 1 China 370 Czech Republic 1 Europe 2 France 2 Germany 6 India 9 Japan 3 Switzerland 2 United Kingdom 12 United States 45 Global 453
AdooQ BioScience, LLC
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View Lastest Price from Fisetin manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Fisetin 528-48-3
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-06-03
Hebei Saisier Technology Co., LTD
Product
Fisetin 528-48-3
Price
US $6.00/KG
Min. Order
1KG
Purity
More than 99%
Supply Ability
2000KG/Month
Release date
2024-04-25
Hebei Mujin Biotechnology Co.,Ltd
Product
Fisetin 528-48-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-11-13

528-48-3, FisetinRelated Search:

Isoflavone Chrysin 7-HYDROXYFLAVONE FLAVONE ISOFLAVONES 3,4',7,8-Tetrahydroxyflavone hydrate Kaempferol TAMARIXETIN 3',4',7,8-TETRAHYDROXYFLAVONE SCUTELLAREIN Luteolin Fisetin 3-methylether FISETIN-3',4'-DIMETHYL ETHER Fisetin 3'',4'',5,7-Tetrahydroxyflavone-3-β-rytinoside FISETIN-3',4'-DIMETHYLETHER(P) FISETIN(SH) FISETIN-3',4'-DIMETHYLETHER(RG)(CALL)

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