2-FLUORO-4-METHYLPHENOL
- Product Name
- 2-FLUORO-4-METHYLPHENOL
- CAS No.
- 452-81-3
- Chemical Name
- 2-FLUORO-4-METHYLPHENOL
- Synonyms
- 2-Fluoro-p-cresol;2-FLUORO-4-METHYLPHENOL;Phenol, 2-fluoro-4-methyl-;3-Fluoro-4-hydroxytoluene, 2-Fluoro-p-cresol
- CBNumber
- CB8451882
- Molecular Formula
- C7H7FO
- Formula Weight
- 126.13
- MOL File
- 452-81-3.mol
2-FLUORO-4-METHYLPHENOL Property
- Boiling point:
- 173.0±20.0 °C(Predicted)
- Density
- 1.164±0.06 g/cm3(Predicted)
- refractive index
- 1.513
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 9.01±0.18(Predicted)
- form
- liquid
- color
- Clear, colourless
- InChI
- InChI=1S/C7H7FO/c1-5-2-3-7(9)6(8)4-5/h2-4,9H,1H3
- InChIKey
- WJKISRFVKIOBCQ-UHFFFAOYSA-N
- SMILES
- C1(O)=CC=C(C)C=C1F
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/21/22-34-22
- Safety Statements
- 26-36/37/39
- RIDADR
- 2922
- Hazard Note
- Irritant
- HazardClass
- 8
- PackingGroup
- Ⅲ
- HS Code
- 2908990000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H302Harmful if swallowed
H312Harmful in contact with skin
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P309IF exposed or if you feel unwell:
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- F597140
- Product name
- 2-Fluoro-4-methylphenol
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- F597140
- Product name
- 2-Fluoro-4-methylphenol
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- PC5944
- Product name
- 2-Fluoro-4-methylphenol
- Packaging
- 25g
- Price
- $103
- Updated
- 2021/12/16
- Product number
- PC5944
- Product name
- 2-Fluoro-4-methylphenol
- Packaging
- 100g
- Price
- $317
- Updated
- 2021/12/16
- Product number
- 2701-3-06
- Product name
- 2-Fluoro-4-methylphenol
- Packaging
- 25g
- Price
- $136
- Updated
- 2021/12/16
2-FLUORO-4-METHYLPHENOL Chemical Properties,Usage,Production
Synthesis
106-44-5
452-81-3
77249-33-3
GENERAL METHOD: To a solution of the substrate 4-methylphenol (1 mmol) in 10 mL of solvent (acetonitrile or methanol) was added Fluoride Reagent 1, 2 or 3 (1.1 mmol). The reaction mixture was stirred under reflux conditions for 2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was dissolved in 50 mL of dichloromethane and filtered to remove insoluble material. The filtrate was washed with 30 mL of water and the organic layer was dried with anhydrous sodium sulfate followed by evaporation of the solvent. The crude product was analyzed by 1H NMR and 19F NMR spectroscopy. The relative distribution and total yield of the fluorinated products were determined by 19F NMR using octafluoronaphthalene (OFN) as an internal standard. The identification of the products was accomplished by comparing their NMR spectral data with those reported in the literature, independently prepared samples, or their conversion to known compounds. In the presence of excess reagents, 2-fluoro-4-alkyl-substituted phenols or alkoxybenzenes (5, see Scheme 1) can be converted to 2,2-difluoro-4-alkyl-3,5-cyclohexadienones (unknown compounds 8b or 8c) or hydrolyzed to 2-fluoro-4-methylphenols (4aa). 4-fluoro-4-alkyl-2,5-cyclohexadienones (6a, 6b, and 6c) were determined by preparative thin layer chromatography (silica gel , dichloromethane/petroleum ether, 4:1) from the crude mixture and identified on the basis of their spectral data. Also, 4-fluoroalkoxybenzene derivatives could be identified by hydrolytic conversion to 4-fluorophenol or by comparison with independently prepared compounds.
References
[1] Journal of Fluorine Chemistry, 1981, vol. 17, p. 159 - 172
[2] European Journal of Organic Chemistry, 2017, vol. 2017, # 17, p. 2469 - 2474
[3] Journal of Fluorine Chemistry, 1981, vol. 17, p. 159 - 172
[4] Journal of Fluorine Chemistry, 2013, vol. 156, p. 276 - 282
[5] Tetrahedron, 2006, vol. 62, # 18, p. 4474 - 4481
2-FLUORO-4-METHYLPHENOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-FLUORO-4-METHYLPHENOL manufacturers
- Product
- 2-FLUORO-4-METHYLPHENOL 452-81-3
- Price
- US $40.00-20.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200000KG
- Release date
- 2024-08-05