3-Fluoro-4-hydroxybenzaldehyde

Uses

Product Name: 3-Fluoro-4-hydroxybenzaldehyde
CAS No.: 405-05-0
Chemical Name: 3-Fluoro-4-hydroxybenzaldehyde
Synonyms: uoro-4-hydroxybenzaL;2-Fluoro-4-formylphenol;4-HYDROXY-3-FLUOROBENZALDEHYDE;3-FLUORO-4-HYDROXYBENZALDEHYDE;3-Fluoro-4-hydroxybenzaldehyde>Benzaldehyde, 3-fluoro-4-hydroxy-;3-Fluoro-4-hydroxybenzaldehyde ,98%
CBNumber: CB2179108
Molecular Formula: C7H5FO2
Formula Weight: 140.11
MOL File: 405-05-0.mol

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3-Fluoro-4-hydroxybenzaldehyde Property

Melting point:: 121-124°C
Boiling point:: 225.6±20.0 °C(Predicted)
Density: 1.4710 (estimate)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder to crystal
pka: 6.52±0.18(Predicted)
color: Light yellow to Yellow to Orange
Sensitive: Air Sensitive
BRN: 3234259
InChI: InChI=1S/C7H5FO2/c8-6-3-5(4-9)1-2-7(6)10/h1-4,10H
InChIKey: QSBHJTCAPWOIIE-UHFFFAOYSA-N
SMILES: C(=O)C1=CC=C(O)C(F)=C1
CAS DataBase Reference: 405-05-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-52-41-37/38
Safety Statements: 26-36-36/37/39-27-39
HazardClass: IRRITANT
HS Code: 29145090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS003043
Product name: 3-Fluoro-4-hydroxybenzaldehyde
Purity: Aldrich<SUP>CPR</SUP>
Packaging: 250 mg
Price: $73.1
Updated: 2025/07/31

TCI Chemical

Product number: F0725
Product name: 3-Fluoro-4-hydroxybenzaldehyde
Purity: >98.0%(GC)
Packaging: 1g
Price: $84
Updated: 2025/07/31

TCI Chemical

Product number: F0725
Product name: 3-Fluoro-4-hydroxybenzaldehyde
Purity: >98.0%(GC)
Packaging: 5g
Price: $206
Updated: 2025/07/31

TRC

Product number: F591905
Product name: 3-Fluoro-4-hydroxybenzaldehyde
Packaging: 5g
Price: $85
Updated: 2021/12/16

AK Scientific

Product number: J54168
Product name: 3-Fluoro-4-hydroxybenzaldehyde
Packaging: 1g
Price: $12
Updated: 2021/12/16

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3-Fluoro-4-hydroxybenzaldehyde Chemical Properties,Usage,Production

Uses

3-Fluoro-4-hydroxybenzaldehyde can be used to synthesize 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic Acid, which is an impurity and intermediate in the preparation of Roflumilast.

Chemical Properties

White crystalline powder

Uses

3-Fluoro-4-hydroxybenzaldehyde can be used to synthesize 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic Acid (C988720), which is an impurity and intermediate in the preparation of Roflumilast (R639700).

Synthesis

351-54-2

405-05-0

The general procedure for the synthesis of 3-fluoro-4-hydroxybenzaldehyde from 3-fluoro-4-methoxybenzaldehyde was as follows: 3-fluoro-4-methoxybenzaldehyde (1 g, 6.5 mmol) was mixed with boron tribromide (1 M solution in dichloromethane, 19.5 mmol) in dichloromethane, and the reaction was stirred for 24 hours under ice bath conditions. Upon completion of the reaction, an excess of anhydrous methanol was added to the reaction system, followed by removal of the solvent and the resulting trimethyl borate by distillation under reduced pressure. The residue was dissolved in methanol and again subjected to reduced pressure distillation to completely remove the residual trimethyl borate. The resulting solid residue was dissolved in ethyl acetate, the organic phase was washed with water (3 x 100 ml) and dried with anhydrous sodium sulfate. The organic solvent was removed by concentration under reduced pressure, and the crude product obtained was purified by silica gel column chromatography (eluent ratio of petroleum ether:ethyl ether=8:2) to finally obtain the pure 3-fluoro-4-hydroxybenzaldehyde. The yield was 91%; the melting point was 120-123 °C; the 1H NMR (CDCl3) data were as follows: δ 6.04 (s, exchangeable with D2O, 1H, OH); 7.16 (m, 1H, aromatic hydrogen); 7.62-7.67 (m, 2H, aromatic hydrogen); 9.86 (s, 1H, CHO). Elemental analysis results (C7H5FO2) Calculated values: C 60.01, H 3.60; measured values: C 59.93, H 3.77.

References

[1] European Journal of Medicinal Chemistry, 2014, vol. 71, p. 112 - 127
[2] Patent: WO2012/11125, 2012, A1. Location in patent: Page/Page column 88-89
[3] Journal of Medicinal Chemistry, 2000, vol. 43, # 4, p. 690 - 705
[4] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 14, p. 5032 - 5038

3-Fluoro-4-hydroxybenzaldehyde Preparation Products And Raw materials

Raw materials

2-Fluorophenol Chloroform Sodium hydroxide

Preparation Products

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3-Fluoro-4-hydroxybenzaldehyde Suppliers

Americas 1 Belgium 1 Canada 1 China 197 Europe 3 France 2 Germany 6 India 8 Italy 1 Japan 1 Slovakia 1 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 27 United States 40 Global 292

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View Lastest Price from 3-Fluoro-4-hydroxybenzaldehyde manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-Fluoro-4-hydroxybenzaldehyde 405-05-0
Price: US $9.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-12-11

Speranza Chemical Co., Ltd.

Product: 3-Fluoro-4-hydroxybenzaldehyde 405-05-0
Price: US $25.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 300 Tons/ year
Release date: 2019-12-25

Shaanxi Dideu Medichem Co. Ltd

Product: 3-Fluoro-4-hydroxybenzaldehyde 405-05-0
Price: US $0.00-0.00/g
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-15

405-05-0, 3-Fluoro-4-hydroxybenzaldehydeRelated Search:

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3-Fluoro-4-hydroxybenzaldehyde ,98%

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3-Fluoro-4-hydroxybenzaldehyde&gt

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Aromatic Aldehydes & Derivatives (substituted)

Benzaldehyde

Fluorine series