3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER
- Product Name
- 3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER
- CAS No.
- 403-01-0
- Chemical Name
- 3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER
- Synonyms
- METHYL 3-FLUORO-4-HYDROXYBENZOATE;RARECHEM AL BF 0259;Fluoro-4-hydroxybenzoate;3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER;Benzoic acid, 3-fluoro-4-hydroxy-, methyl ester
- CBNumber
- CB9281077
- Molecular Formula
- C8H7FO3
- Formula Weight
- 170.14
- MOL File
- 403-01-0.mol
3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER Property
- Melting point:
- 91-93℃
- Boiling point:
- 259.9±25.0℃ (760 Torr)
- Density
- 1.309±0.06 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 111.0±23.2℃
- storage temp.
- Sealed in dry,Room Temperature
- form
- Solid
- pka
- 7.10±0.18(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M305543
- Product name
- Methyl3-fluoro-4-hydroxybenzoate
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CS-W005048
- Product name
- Methyl3-fluoro-4-hydroxybenzoate
- Purity
- 99.27%
- Packaging
- 5g
- Price
- $38
- Updated
- 2021/12/16
- Product number
- CS-W005048
- Product name
- Methyl3-fluoro-4-hydroxybenzoate
- Purity
- 99.27%
- Packaging
- 10g
- Price
- $63
- Updated
- 2021/12/16
- Product number
- CS-W005048
- Product name
- Methyl3-fluoro-4-hydroxybenzoate
- Purity
- 99.27%
- Packaging
- 25g
- Price
- $138
- Updated
- 2021/12/16
- Product number
- 209529
- Product name
- Methyl3-fluoro-4-hydroxybenzoate
- Purity
- 98%
- Packaging
- 25g
- Price
- $149
- Updated
- 2021/12/16
3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER Chemical Properties,Usage,Production
Synthesis
67-56-1
350-29-8
403-01-0
Procedure for the synthesis of methyl 3-fluoro-4-hydroxybenzoate (T10.1): 3-fluoro-4-hydroxybenzoic acid (5.03 g, 32.22 mmol, commercially available from Sigma-Aldrich, St. Louis, MO, USA), methanol (50.0 mL), and cold sulfuric acid (2.0 mL) were added to a round bottom flask. The reaction mixture was heated to 80 °C and the progress of the reaction was monitored by thin layer chromatography (TLC). After 20.5 hours of reaction, the solvent was removed by distillation under reduced pressure. The residue was diluted with ether and the organic phase was sequentially washed twice with saturated aqueous sodium bicarbonate and once with brine, followed by drying with anhydrous sodium sulfate. After filtration, the organic solvent was removed by evaporation under reduced pressure to give the product T10.1 (4.79 g, 87% yield) as a white solid. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.81 (2H, m), 7.06 (1H, t, J = 8.4 Hz), 5.62 (1H, d, J = 4.3 Hz), 3.91 (3H, s).
References
[1] Patent: WO2010/45258, 2010, A2. Location in patent: Page/Page column 155
[2] Patent: WO2009/111056, 2009, A1. Location in patent: Page/Page column 227-228
[3] Patent: WO2008/87529, 2008, A1. Location in patent: Page/Page column 42; 43; 119-120
[4] Patent: WO2010/9290, 2010, A1. Location in patent: Page/Page column 58
[5] Patent: US2007/191603, 2007, A1. Location in patent: Page/Page column 35
3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER manufacturers
- Product
- 3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER 403-01-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-20
- Product
- 3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER 403-01-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-25