ChemicalBook > CAS DataBase List > 3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER

3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER

Product Name
3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER
CAS No.
403-01-0
Chemical Name
3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER
Synonyms
METHYL 3-FLUORO-4-HYDROXYBENZOATE;RARECHEM AL BF 0259;Fluoro-4-hydroxybenzoate;3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER;Benzoic acid, 3-fluoro-4-hydroxy-, methyl ester
CBNumber
CB9281077
Molecular Formula
C8H7FO3
Formula Weight
170.14
MOL File
403-01-0.mol
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3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER Property

Melting point:
91-93℃
Boiling point:
259.9±25.0℃ (760 Torr)
Density 
1.309±0.06 g/cm3 (20 ºC 760 Torr)
Flash point:
111.0±23.2℃
storage temp. 
Sealed in dry,Room Temperature
form 
Solid
pka
7.10±0.18(Predicted)
Appearance
White to off-white Solid
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Safety

HS Code 
2916399090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
M305543
Product name
Methyl3-fluoro-4-hydroxybenzoate
Packaging
1g
Price
$75
Updated
2021/12/16
ChemScene
Product number
CS-W005048
Product name
Methyl3-fluoro-4-hydroxybenzoate
Purity
99.27%
Packaging
5g
Price
$38
Updated
2021/12/16
ChemScene
Product number
CS-W005048
Product name
Methyl3-fluoro-4-hydroxybenzoate
Purity
99.27%
Packaging
10g
Price
$63
Updated
2021/12/16
ChemScene
Product number
CS-W005048
Product name
Methyl3-fluoro-4-hydroxybenzoate
Purity
99.27%
Packaging
25g
Price
$138
Updated
2021/12/16
Oakwood
Product number
209529
Product name
Methyl3-fluoro-4-hydroxybenzoate
Purity
98%
Packaging
25g
Price
$149
Updated
2021/12/16
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3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER Chemical Properties,Usage,Production

Synthesis

67-56-1

350-29-8

403-01-0

Procedure for the synthesis of methyl 3-fluoro-4-hydroxybenzoate (T10.1): 3-fluoro-4-hydroxybenzoic acid (5.03 g, 32.22 mmol, commercially available from Sigma-Aldrich, St. Louis, MO, USA), methanol (50.0 mL), and cold sulfuric acid (2.0 mL) were added to a round bottom flask. The reaction mixture was heated to 80 °C and the progress of the reaction was monitored by thin layer chromatography (TLC). After 20.5 hours of reaction, the solvent was removed by distillation under reduced pressure. The residue was diluted with ether and the organic phase was sequentially washed twice with saturated aqueous sodium bicarbonate and once with brine, followed by drying with anhydrous sodium sulfate. After filtration, the organic solvent was removed by evaporation under reduced pressure to give the product T10.1 (4.79 g, 87% yield) as a white solid. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.81 (2H, m), 7.06 (1H, t, J = 8.4 Hz), 5.62 (1H, d, J = 4.3 Hz), 3.91 (3H, s).

References

[1] Patent: WO2010/45258, 2010, A2. Location in patent: Page/Page column 155
[2] Patent: WO2009/111056, 2009, A1. Location in patent: Page/Page column 227-228
[3] Patent: WO2008/87529, 2008, A1. Location in patent: Page/Page column 42; 43; 119-120
[4] Patent: WO2010/9290, 2010, A1. Location in patent: Page/Page column 58
[5] Patent: US2007/191603, 2007, A1. Location in patent: Page/Page column 35

3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER Suppliers

China 67 Germany 1 India 1 United Kingdom 5 United States 20 Global 94
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View Lastest Price from 3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER 403-01-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-05-20
Career Henan Chemical Co
Product
3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER 403-01-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-12-25

403-01-0, 3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTERRelated Search:

Methyl 3-fluoro-5-hydroxybenzoate 3-FLUORO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 4-FLUORO-6-HYDROXY-BENZOIC ACID METHYL ESTER 3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER 3-Fluoro-4-hydroxybenzoic acid METHYL 4-FLUORO-3-HYDROXYBENZOATE 2-FLUORO-6-HYDROXY-BENZOIC ACID METHYL ESTER 5-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER 3-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER METHYL 3-FLUORO-4-METHOXYBENZOATE RARECHEM AL BI 0055 2-hydroxyethyl 3-fluoro-4-hydroxybenzoate 2,3-DIFLUORO-4-HYDROXYBENZOIC ACID METHYL ESTER RARECHEM AL BI 0259 RARECHEM AL BI 0900 RARECHEM AL BF 0900 2,3-DIFLUORO-4-HYDROXYBENZOIC ACID ETHYL ESTER (R)-1-METHYLHEPTYL 4-(4'-N-DODECYLOXYBIPHENYL-4-YL-CARBONYLOXY)-3-FLUOROBENZOATE

  • 3-FLUORO-4-HYDROXY-BENZOIC ACID METHYL ESTER
  • RARECHEM AL BF 0259
  • Fluoro-4-hydroxybenzoate
  • METHYL 3-FLUORO-4-HYDROXYBENZOATE
  • Benzoic acid, 3-fluoro-4-hydroxy-, methyl ester
  • 403-01-0
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  • FluoroCompounds
  • pharmacetical