3-Fluoro-4-methoxybenzaldehyde

Product Name: 3-Fluoro-4-methoxybenzaldehyde
CAS No.: 351-54-2
Chemical Name: 3-Fluoro-4-methoxybenzaldehyde
Synonyms: 3-Fluoroanisaldehyde;3-FLUORO-4-ANISALDEHYDE;3-FLUORO-P-ANISALDEHYDE;3-fluoro-para-anisaldehyde;3-Fluoro-p-anisaldehyde>3-FLUORO-4-METHOXYBENZALDEHYDE;4-Methoxy-3-fluorobenzaldehyde;Benzaldehyde, 3-fluoro-4-methoxy-;3-Fluoro-4-methoxybenzaldehyde,98%;3-fluoro-4-methoxybenzaldehyde(SALTDATA: FREE)
CBNumber: CB3466360
Molecular Formula: C8H7FO2
Formula Weight: 154.14
MOL File: 351-54-2.mol

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3-Fluoro-4-methoxybenzaldehyde Property

Melting point:: 34-35 °C (lit.)
Boiling point:: 129-132°C 11mm
Density: 1.192±0.06 g/cm3(Predicted)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Oil
color: Clear Colourless
Sensitive: Air Sensitive
BRN: 1942621
InChI: InChI=1S/C8H7FO2/c1-11-8-3-2-6(5-10)4-7(8)9/h2-5H,1H3
InChIKey: SOQCZBSZZLWDGU-UHFFFAOYSA-N
SMILES: C(=O)C1=CC=C(OC)C(F)=C1
CAS DataBase Reference: 351-54-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 36/37/38-22
Safety Statements: 37/39-26-36
WGK Germany: 3
Hazard Note: Irritant
HazardClass: IRRITANT, AIR SENSITIVE
HS Code: 29130000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 155586
Product name: 3-Fluoro-4-methoxybenzaldehyde
Purity: 99%
Packaging: 1g
Price: $83.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: 155586
Product name: 3-Fluoro-4-methoxybenzaldehyde
Purity: 99%
Packaging: 5g
Price: $135
Updated: 2025/07/31

TCI Chemical

Product number: F0480
Product name: 3-Fluoro-p-anisaldehyde
Purity: >98.0%(GC)
Packaging: 1g
Price: $32
Updated: 2025/07/31

TCI Chemical

Product number: F0480
Product name: 3-Fluoro-p-anisaldehyde
Purity: >98.0%(GC)
Packaging: 5g
Price: $92
Updated: 2025/07/31

TRC

Product number: F598750
Product name: 3-Fluoro-4-methoxybenzaldehyde
Packaging: 5g
Price: $60
Updated: 2021/12/16

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3-Fluoro-4-methoxybenzaldehyde Chemical Properties,Usage,Production

Chemical Properties

white to light yellow low melting crystalline mass

Uses

3-Fluoro-4-methoxybenzaldehyde is a useful reagent in the synthesis of resveratrol derivatives as potent inhibitors of lysine specific demethylase 1 (LSD1), a therapeutic target for cancer treatment and other related diseases. Also a reagent for the synthesis of substituted pyrazolyl piperidine derivatives as antiplatelet agents with antiplatelet aggregation activity in the human body.

General Description

The nuclear magnetic resonance spectral parameters for 3-Fluoro-4-methoxybenzaldehyde has been studied.

Synthesis

96047-32-4

351-54-2

GENERAL METHODS: A mixed solution of (3-fluoro-4-methoxyphenyl)methanol (1 mmol), N-bromosuccinimide (NBS, 1.3 eq.), potassium acetate (KOAc, 1.5 eq.), water (H2O, 1.5 mL), and dichloromethane (CH2Cl2, 0.5 mL) was placed in a 25 mL flask and magnetically stirred for 10 hours at room temperature. Upon completion of the reaction, the reaction mixture was poured into water (10 mL) and extracted with ethyl acetate (EtOAc, 3 x 10 mL). The organic phases were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to remove the solvent. The residue was purified by rapid column chromatography on silica gel, using petroleum ether (PE) or mixed solvent of petroleum ether/ethyl acetate (PE/EtOAc) as eluent to obtain the target product 3-fluoro-4-methoxybenzaldehyde. The structure of the product was confirmed by gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance hydrogen spectroscopy (1H NMR).

References

[1] Applied Organometallic Chemistry, 2016, vol. 30, # 7, p. 577 - 580
[2] Letters in Organic Chemistry, 2017, vol. 14, # 4, p. 254 - 260
[3] Molecules, 2018, vol. 23, # 8,
[4] ChemSusChem, 2017, vol. 10, # 17, p. 3497 - 3505

3-Fluoro-4-methoxybenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Fluoro-4-methoxybenzaldehyde Suppliers

Americas 1 Belgium 3 China 189 Europe 4 France 1 Germany 5 India 10 Italy 1 Japan 3 Slovakia 1 Switzerland 3 Ukraine 1 United Kingdom 23 United States 45 Global 290

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View Lastest Price from 3-Fluoro-4-methoxybenzaldehyde manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 3-Fluoro-4-methoxybenzaldehyde 351-54-2
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99% min
Supply Ability: 100kg
Release date: 2025-08-18

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-Fluoro-4-methoxybenzaldehyde 351-54-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-12

Speranza Chemical Co., Ltd.

Product: 3-Fluoro-4-methoxybenzaldehyde 351-54-2
Price: US $20.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200tons/ year
Release date: 2020-03-11

351-54-2, 3-Fluoro-4-methoxybenzaldehydeRelated Search:

3-Fluoro-4-methoxybenzoic acid Benzoic acid, 4-ethoxy-2,3-difluoro- (9CI) 3,5-DIFLUORO-4-METHOXYACETOPHENONE 3-(3-FLUORO-4-METHOXYBENZOYL)PROPIONIC ACID 3,5-DIFLUORO-4-METHOXYBENZOIC ACID 3-Fluoro-4-methoxybenzoyl chloride 2,3-Difluoro-4-methoxybenzoic acid 3-Fluoro-4-methoxybenzaldehyde 2-Fluoro-5-methoxybenzaldehyde98%,2-Fluoro-5-methoxybenzaldehyde 98%,2-FLUORO-5-METHOXYBENZALDEHYDE 4-FLUORO-2-METHOXYBENZALDEHYDE 3-FLUORO-2-METHOXYBENZALDEHYDE 3,5-Difluoro-4-methoxybenzaldehyde 4,5-DIFLUORO-2-METHOXYBENZALDEHYDE 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE 2-Fluoro-6-methoxybenzaldehyde99%,2-Fluoro-6-methoxybenzaldehyde 99%,2-FLUORO-6-METHOXYBENZALDEHYDE 2-CHLORO-6-FLUORO-3-METHOXYBENZALDEHYDE 6-bromo-2-fluoro-3-methoxybenzaldehyde 2,3-Difluoro-4-methoxybenzaldehyde

3-FLUORO-P-ANISALDEHYDE

3-FLUORO-4-ANISALDEHYDE

3-FLUORO-4-METHOXYBENZALDEHYDE

3-Fluoro-4-Methoxybenzaldehyde/3-Fluoro-P-Anisaldehyde/M-Fluoro-P-Anisaldehyde/

3-fluoro-4-methoxybenzaldehyde(SALTDATA: FREE)

2-Fluoro-4-formylanisole, 3-Fluoro-p-anisaldehyde

3-Fluoroanisaldehyde

3-Fluoro-4-methoxybenzaldehyde,98%

3-fluoro-para-anisaldehyde

4-Methoxy-3-fluorobenzaldehyde

3-Fluoro-p-anisaldehyde&gt

Benzaldehyde, 3-fluoro-4-methoxy-

351-54-2

ALDEHYDE

Building Blocks

C8

Carbonyl Compounds

Aldehydes

Organic Building Blocks

Fluorine series

C8-C12

Carbonyl Compounds

Chemical Synthesis

Fluorinated Building Blocks

Organic Building Blocks

Organic Fluorinated Building Blocks

Other Fluorinated Organic Building Blocks

Aldehydes

Aryl Fluorinated Building Blocks

Building Blocks

C8

FINE Chemical & INTERMEDIATES

Aromatic Aldehydes & Derivatives (substituted)

Benzaldehyde

Miscellaneous

Adehydes, Acetals & Ketones

Anisoles, Alkyloxy Compounds & Phenylacetates

Fluorine Compounds