4-FLUORO-2-METHOXYBENZALDEHYDE

Product Name: 4-FLUORO-2-METHOXYBENZALDEHYDE
CAS No.: 450-83-9
Chemical Name: 4-FLUORO-2-METHOXYBENZALDEHYDE
Synonyms: 4-Fluoro-o-anisaldehyde;4-Fluoro-o-anisaldehyde>Fluoromethoxybenzaldehyde4;2-METHOXY-4-FLUOROBENZALDEHYDE;4-FLUORO-2-METHOXYBENZALDEHYDE;Benzaldehyde, 4-fluoro-2-methoxy-;4-Fluoro-2-methoxybenzaldehyde 99%;5-Fluoro-2-formylanisole, 4-Fluoro-o-anisaldehyde;5-Fluoro-2-formylanisole, 5-Fluoro-2-formylphenyl methyl ether
CBNumber: CB6735706
Molecular Formula: C8H7FO2
Formula Weight: 154.14
MOL File: 450-83-9.mol

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4-FLUORO-2-METHOXYBENZALDEHYDE Property

Melting point:: 55 °C
Boiling point:: 224.6±20.0 °C(Predicted)
Density: 1.192±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: soluble in Methanol
form: powder to lump
color: White to Orange to Green
Sensitive: Air Sensitive
CAS DataBase Reference: 450-83-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-52-41-37/38-22
Safety Statements: 26-36-39
Hazard Note: Irritant
HS Code: 29124990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: F0827
Product name: 4-Fluoro-o-anisaldehyde
Purity: >97.0%(GC)
Packaging: 1g
Price: $40
Updated: 2025/07/31

TCI Chemical

Product number: F0827
Product name: 4-Fluoro-o-anisaldehyde
Purity: >97.0%(GC)
Packaging: 5g
Price: $161
Updated: 2025/07/31

TRC

Product number: F595125
Product name: 4-Fluoro-2-methoxy-benzaldehyde
Packaging: 1g
Price: $130
Updated: 2021/12/16

Apolloscientific

Product number: PC8206
Product name: 4-Fluoro-2-methoxybenzaldehyde
Purity: 97%
Packaging: 25g
Price: $130
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2615-3-01
Product name: 4-Fluoro-2-methoxybenzaldehyde
Purity: 98%
Packaging: 5G
Price: $77
Updated: 2021/12/16

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4-FLUORO-2-METHOXYBENZALDEHYDE Chemical Properties,Usage,Production

Uses

4-Fluoro-2-methoxy-benzaldehyde is used in the synthesis of imidazopyridazinones acting as novel PDE7 inhibitors for application towards Parkinson’s disease treatment.

Synthesis

50-00-0

372-20-3

77-78-1

450-83-9

146137-74-8

3-Fluorophenol (20 g, 0.2 mol) was dissolved in molecular sieve-dried acetonitrile (500 mL), stirred under argon protection, and anhydrous magnesium chloride (102 g, 1.1 mol) was added. after 5 min, triethylamine (225 mL, 1.6 mol) was added, and an exothermic mixture was observed. After continued stirring for 30 min, paraformaldehyde (63 g) was added and the reaction was carried out for 3 h at 50 °C. Upon completion of the reaction, the pH was adjusted to 4 with 1N aqueous hydrochloric acid and the mixture was subsequently extracted with ethyl acetate (3 x 150 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give 49.9 g of a dark red oily crude product (containing 4-fluoro-2-methoxybenzaldehyde and 2-fluoro-6-methoxybenzaldehyde), which was subsequently solidified. The crude product was dissolved in tetrahydrofuran (100 mL), potassium carbonate (81.2 g, 0.6 mol) and dimethyl sulfate (25.4 mL, 0.3 mol) were added, and the reaction was carried out at 40 °C overnight. Complete consumption of the raw materials was confirmed by TLC. Potassium carbonate was removed by filtration and the solid was washed with ethyl acetate (3 x 100 mL). The organic phases were combined, dried and concentrated with anhydrous magnesium sulfate. The residue was purified by column chromatography (eluent was petroleum ether/ethyl acetate, 15:1, v/v) to afford the intermediate 4-fluoro-2-methoxybenzaldehyde (15.8 g) and the by-product 2-fluoro-6-methoxybenzaldehyde (2.8 g), both as pale yellow solids, in an overall yield of 68%. 4-fluoro-2-methoxybenzaldehyde: melting point: °C; 1H NMR (300 MHz. CDCl3) δ 10.4 (1H, s), 7.85 (1H, dd, J = 8.4 Hz, 6.9 Hz), 6.75-6.67 (2H, m), 3.93 (3H, d, J =11.0 Hz), 13C NMR (75MHz, CDCl3) δ 130.9 (d, J =11.6 Hz), 121.6 (d, J = 2.7 Hz), 108.1 (d, J =22.1 Hz), 99.7 (d, J =25.7 Hz), 56.0. 2-Fluoro-6-methoxybenzaldehyde: melting point: 60-61 °C; 1H NMR (300 MHz, CDCl3) δ 10.3 (1H, s), 7.41 (1H, dd, J =15.0 Hz, 8.4 Hz), 6.71-6.61 (2.2). 6.71-6.61 (2H, m), 3.85 (3H, s), 13C NMR (75MHz, CDCl3) δ 187.4 (d, J = 3.4 Hz), 163.3 (d, J = 260.5 Hz), 162.2 (d, J = 5.4 Hz), 136.2 (d, J = 12.0 Hz), 114.0, 108.6 ( d, J = 21.3 Hz), 107.3 (d, J = 3.5 Hz), 56.3.

References

[1] European Journal of Organic Chemistry, 2016, vol. 2016, # 7, p. 1429 - 1438
[2] Patent: CN104557654, 2017, B. Location in patent: Paragraph 0086-0088

4-FLUORO-2-METHOXYBENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-FLUORO-2-METHOXYBENZALDEHYDE Suppliers

Americas 1 Belgium 1 China 158 Europe 1 France 1 Germany 4 India 9 Italy 1 Japan 1 The Netherlands 1 United Kingdom 18 United States 32 Global 228

J & K SCIENTIFIC LTD.

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View Lastest Price from 4-FLUORO-2-METHOXYBENZALDEHYDE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-FLUORO-2-METHOXYBENZALDEHYDE 450-83-9
Price: US $35.00-15.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2024-07-30

Honest Joy Holdings Limited

Product: 4-Fluoro-2-methoxybenzaldehyde 450-83-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.3%
Supply Ability: 100 tons
Release date: 2022-02-21

Career Henan Chemical Co

Product: 4-Fluoro-2-Methoxybenzaldehyde 450-83-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-09

450-83-9, 4-FLUORO-2-METHOXYBENZALDEHYDERelated Search:

4-Fluoro-2-methoxybenzonitrile 4-FLUORO-2-METHOXYACETOPHENONE 4,5-DIFLUORO-2-METHOXYBENZALDEHYDE 4-Fluoro-2-methoxybenzoic acid 4-FLUORO-2-METHOXYBENZALDEHYDE 7-Fluoro-4-chromanone 4,5-DIFLUORO-2-METHOXYBENZOIC ACID 3,4-Difluoro-2-methoxybenzoic acid 3-FLUORO-4-METHOXYBENZALDEHYDE,3-Fluoro-4-Methoxybenzaldehyde/3-Fluoro-P-Anisaldehyde/M-Fluoro-P-Anisaldehyde/ 3-FLUORO-2-METHOXYBENZALDEHYDE 2,3-DIFLUORO-6-METHOXYBENZALDEHYDE 3,5-Difluoro-4-methoxybenzaldehyde 2-Fluoro-5-methoxybenzaldehyde 98%,2-Fluoro-5-methoxybenzaldehyde98%,2-FLUORO-5-METHOXYBENZALDEHYDE 2,6-Difluoro-3-methoxyBenzaldehyde 3,5-DIFLUORO-2-METHOXYBENZALDEHYDE 4-FLUORO-3-METHOXYBENZALDEHYDE,4-Fluoro-3-methoxybenzaldehyde97%,4-Fluoro-3-methoxybenzaldehyde 97% 6-FLUOROCHROMONE-3-PROPIONIC ACID 4-FLUORO-2-METHOXYBENZAMIDE

4-Fluoro-o-anisaldehyde

5-Fluoro-2-formylanisole, 4-Fluoro-o-anisaldehyde

4-FLUORO-2-METHOXYBENZALDEHYDE

2-METHOXY-4-FLUOROBENZALDEHYDE

Fluoromethoxybenzaldehyde4

4-Fluoro-2-methoxybenzaldehyde 99%

5-Fluoro-2-formylanisole, 5-Fluoro-2-formylphenyl methyl ether

4-Fluoro-o-anisaldehyde&gt

Benzaldehyde, 4-fluoro-2-methoxy-

450-83-9

Aromatic Aldehydes & Derivatives (substituted)

Benzaldehyde

Adehydes, Acetals & Ketones

Anisoles, Alkyloxy Compounds & Phenylacetates

Fluorine Compounds