4-FLUORO-3-METHOXYBENZALDEHYDE
- Product Name
- 4-FLUORO-3-METHOXYBENZALDEHYDE
- CAS No.
- 128495-46-5
- Chemical Name
- 4-FLUORO-3-METHOXYBENZALDEHYDE
- Synonyms
- uoro-m-anisaL;4-FLUORO-M-ANISALDEHYDE;4-Fluoro-m-anisaldehyde>3-METHOXY-4-FLUOROBENZALDEHYDE;4-FLUORO-3-METHOXYBENZALDEHYDE;4-Fluoro-3-methoxybenzaldehyde97%;Benzaldehyde, 4-fluoro-3-methoxy-;4-Fluoro-3-methoxybenzaldehyde 97%;4-Fluoro-M-anisaldehyde, 96.0%(GC);4-Fluoro-3-methoxybenzaldehyde ,98%
- CBNumber
- CB7119640
- Molecular Formula
- C8H7FO2
- Formula Weight
- 154.14
- MOL File
- 128495-46-5.mol
4-FLUORO-3-METHOXYBENZALDEHYDE Property
- Melting point:
- 58-62 °C(lit.)
- Boiling point:
- 93 °C(Press: 4.5 Torr)
- Density
- 1.192±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- color
- White to Light yellow
- Sensitive
- Air Sensitive
- BRN
- 5178063
- InChI
- InChI=1S/C8H7FO2/c1-11-8-4-6(5-10)2-3-7(8)9/h2-5H,1H3
- InChIKey
- NALVGTOMKSKFFV-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC=C(F)C(OC)=C1
- CAS DataBase Reference
- 128495-46-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-37/38-41-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 2
- HazardClass
- IRRITANT
- HS Code
- 29124990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 652687
- Product name
- 4-Fluoro-3-methoxybenzaldehyde
- Purity
- 97%
- Packaging
- 5g
- Price
- $38.57
- Updated
- 2025/07/31
- Product number
- 652687
- Product name
- 4-Fluoro-3-methoxybenzaldehyde
- Purity
- 97%
- Packaging
- 25g
- Price
- $237
- Updated
- 2023/06/20
- Product number
- F0401
- Product name
- 4-Fluoro-m-anisaldehyde
- Purity
- >96.0%(GC)
- Packaging
- 1g
- Price
- $27
- Updated
- 2025/07/31
- Product number
- F0401
- Product name
- 4-Fluoro-m-anisaldehyde
- Purity
- >96.0%(GC)
- Packaging
- 5g
- Price
- $82
- Updated
- 2025/07/31
- Product number
- F0401
- Product name
- 4-Fluoro-m-anisaldehyde
- Purity
- >96.0%(GC)
- Packaging
- 25g
- Price
- $247
- Updated
- 2025/07/31
4-FLUORO-3-METHOXYBENZALDEHYDE Chemical Properties,Usage,Production
Chemical Properties
White to yellow to tan powder or crystal or crystalline powder
Uses
Synthesis Reference(s)
Journal of Medicinal Chemistry, 33, p. 2408, 1990 DOI: 10.1021/jm00171a014
Synthesis
128495-45-4
128495-46-5
General procedure for the synthesis of 3-methoxy-4-fluorobenzaldehyde from 3-methoxy-4-fluorobenzyl alcohol: (4-fluoro-3-methoxyphenyl)methanol (5.00 g, 0.03 mol) was mixed with manganese dioxide (33.4 g, 0.38 mol) in dichloromethane (100 mL) under nitrogen protection, and the reaction was stirred for 16 hr under mild reflux conditions. Upon completion of the reaction, the reaction mixture was cooled to room temperature, filtered through Arbacel, and the filtrate was concentrated in vacuum to afford 3-methoxy-4-fluorobenzaldehyde (4.18 g, 0.027 mol, 85% yield) as a white solid. The product was characterized by 1H NMR (CDCl3, 400 MHz): δ 3.96 (s, 3H), 7.23 (d, 1H), 7.43 (m, 1H), 7.50 (d, 1H), 9.91 (s, 1H). The melting point is 61-63°C. Elemental analysis results: measured value C, 62.18; H, 4.54%. Theoretical value (C8H7FO2): C, 62.34; H, 4.58%.
References
[1] Journal of Medicinal Chemistry, 1990, vol. 33, # 9, p. 2408 - 2412
[2] Patent: WO2004/52372, 2004, A1. Location in patent: Page 72
[3] Patent: WO2008/87512, 2008, A1. Location in patent: Page/Page column 43
[4] Patent: EP2862571, 2015, A1. Location in patent: Paragraph 0164; 0165
[5] Patent: US2015/166559, 2015, A1. Location in patent: Paragraph 0220; 0221
4-FLUORO-3-METHOXYBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-FLUORO-3-METHOXYBENZALDEHYDE manufacturers
- Product
- 4-FLUORO-3-METHOXYBENZALDEHYDE 128495-46-5
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-06
- Product
- 4-FLUORO-3-METHOXYBENZALDEHYDE 128495-46-5
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 10000MT
- Release date
- 2023-08-08
- Product
- 4-FLUORO-3-METHOXYBENZALDEHYDE 128495-46-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 200KG
- Release date
- 2018-08-19