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4-FLUORO-3-METHOXYBENZALDEHYDE

Product Name
4-FLUORO-3-METHOXYBENZALDEHYDE
CAS No.
128495-46-5
Chemical Name
4-FLUORO-3-METHOXYBENZALDEHYDE
Synonyms
uoro-m-anisaL;4-FLUORO-M-ANISALDEHYDE;4-Fluoro-m-anisaldehyde>3-METHOXY-4-FLUOROBENZALDEHYDE;4-FLUORO-3-METHOXYBENZALDEHYDE;4-Fluoro-3-methoxybenzaldehyde97%;Benzaldehyde, 4-fluoro-3-methoxy-;4-Fluoro-3-methoxybenzaldehyde 97%;4-Fluoro-M-anisaldehyde, 96.0%(GC);4-Fluoro-3-methoxybenzaldehyde ,98%
CBNumber
CB7119640
Molecular Formula
C8H7FO2
Formula Weight
154.14
MOL File
128495-46-5.mol
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4-FLUORO-3-METHOXYBENZALDEHYDE Property

Melting point:
58-62 °C(lit.)
Boiling point:
93 °C(Press: 4.5 Torr)
Density 
1.192±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
color 
White to Light yellow
Sensitive 
Air Sensitive
BRN 
5178063
InChI
InChI=1S/C8H7FO2/c1-11-8-4-6(5-10)2-3-7(8)9/h2-5H,1H3
InChIKey
NALVGTOMKSKFFV-UHFFFAOYSA-N
SMILES
C(=O)C1=CC=C(F)C(OC)=C1
CAS DataBase Reference
128495-46-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-37/38-41-36/37/38
Safety Statements 
26-36
WGK Germany 
2
HazardClass 
IRRITANT
HS Code 
29124990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
652687
Product name
4-Fluoro-3-methoxybenzaldehyde
Purity
97%
Packaging
5g
Price
$38.57
Updated
2025/07/31
Sigma-Aldrich
Product number
652687
Product name
4-Fluoro-3-methoxybenzaldehyde
Purity
97%
Packaging
25g
Price
$237
Updated
2023/06/20
TCI Chemical
Product number
F0401
Product name
4-Fluoro-m-anisaldehyde
Purity
>96.0%(GC)
Packaging
1g
Price
$27
Updated
2025/07/31
TCI Chemical
Product number
F0401
Product name
4-Fluoro-m-anisaldehyde
Purity
>96.0%(GC)
Packaging
5g
Price
$82
Updated
2025/07/31
TCI Chemical
Product number
F0401
Product name
4-Fluoro-m-anisaldehyde
Purity
>96.0%(GC)
Packaging
25g
Price
$247
Updated
2025/07/31
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4-FLUORO-3-METHOXYBENZALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

White to yellow to tan powder or crystal or crystalline powder

Uses

Synthesis Reference(s)

Journal of Medicinal Chemistry, 33, p. 2408, 1990 DOI: 10.1021/jm00171a014

Synthesis

128495-45-4

128495-46-5

General procedure for the synthesis of 3-methoxy-4-fluorobenzaldehyde from 3-methoxy-4-fluorobenzyl alcohol: (4-fluoro-3-methoxyphenyl)methanol (5.00 g, 0.03 mol) was mixed with manganese dioxide (33.4 g, 0.38 mol) in dichloromethane (100 mL) under nitrogen protection, and the reaction was stirred for 16 hr under mild reflux conditions. Upon completion of the reaction, the reaction mixture was cooled to room temperature, filtered through Arbacel, and the filtrate was concentrated in vacuum to afford 3-methoxy-4-fluorobenzaldehyde (4.18 g, 0.027 mol, 85% yield) as a white solid. The product was characterized by 1H NMR (CDCl3, 400 MHz): δ 3.96 (s, 3H), 7.23 (d, 1H), 7.43 (m, 1H), 7.50 (d, 1H), 9.91 (s, 1H). The melting point is 61-63°C. Elemental analysis results: measured value C, 62.18; H, 4.54%. Theoretical value (C8H7FO2): C, 62.34; H, 4.58%.

References

[1] Journal of Medicinal Chemistry, 1990, vol. 33, # 9, p. 2408 - 2412
[2] Patent: WO2004/52372, 2004, A1. Location in patent: Page 72
[3] Patent: WO2008/87512, 2008, A1. Location in patent: Page/Page column 43
[4] Patent: EP2862571, 2015, A1. Location in patent: Paragraph 0164; 0165
[5] Patent: US2015/166559, 2015, A1. Location in patent: Paragraph 0220; 0221

4-FLUORO-3-METHOXYBENZALDEHYDE Preparation Products And Raw materials

Raw materials

Acetone Diethyl ether Ethyl acetate Dichloromethane Potassium permanganate 2-FLUORO-5-METHYLPHENOL PETROLEUM ETHER Sulfuric acid Dimethyl sulfate

Preparation Products

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4-FLUORO-3-METHOXYBENZALDEHYDE Suppliers

Americas 1 China 187 Europe 1 Germany 4 India 10 Italy 1 Japan 3 Switzerland 2 The Netherlands 1 United Kingdom 23 United States 36 Global 269
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from 4-FLUORO-3-METHOXYBENZALDEHYDE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-FLUORO-3-METHOXYBENZALDEHYDE 128495-46-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-06
Henan Bao Enluo International TradeCo.，LTD
Product
4-FLUORO-3-METHOXYBENZALDEHYDE 128495-46-5
Price
US $50.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
10000MT
Release date
2023-08-08
Career Henan Chemical Co
Product
4-FLUORO-3-METHOXYBENZALDEHYDE 128495-46-5
Price
US $1.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
200KG
Release date
2018-08-19

128495-46-5, 4-FLUORO-3-METHOXYBENZALDEHYDERelated Search:

4-FLUORO-3-METHOXYBENZALDEHYDE 4-FLUORO-3-METHOXYBENZOIC ACID 4-FLUORO-3-METHOXYACETOPHENONE 3-Methoxy-2,4,5-trifluorobenzoic acid 3-METHOXY-2,4,5-TRIFLUOROBENZAMIDE Levofloxacin carboxylic acid 2,4-DIFLUORO-3-METHOXYBENZALDEHYDE 2,4,5-Trifluoro-3-methoxybenzoyl chloride 4-Fluoro-3-phenoxybenzaldehyde 2,4-Difluoro-3-methoxybenzoic acid 2,4-DIFLUORO-3-METHOXY ACETOPHENONE 6-CHLORO-2-FLUORO-3-METHOXYBENZALDEHYDE 3-CHLORO-5-FLUORO-4-METHOXYBENZALDEHYDE 2-FLUORO-4-METHOXYBENZALDEHYDE,2-Fluoro-4-methoxybenzaldehyde 97%,2-Fluoro-4-methoxybenzaldehyde97% 3-Fluoro-5-methoxybenzaldehyde 97%,3-Fluoro-5-methoxybenzaldehyde97% 3-FLUORO-4-METHOXYBENZALDEHYDE,3-Fluoro-4-Methoxybenzaldehyde/3-Fluoro-P-Anisaldehyde/M-Fluoro-P-Anisaldehyde/ 2-FLUORO-5-METHOXYBENZALDEHYDE,2-Fluoro-5-methoxybenzaldehyde 98%,2-Fluoro-5-methoxybenzaldehyde98% 4-FLUORO-2-METHOXYBENZALDEHYDE

  • 4-Fluoro-3-methoxybenzaldehyde 97%
  • 4-Fluoro-3-methoxybenzaldehyde97%
  • 4-FLUORO-M-ANISALDEHYDE
  • 4-FLUORO-3-METHOXYBENZALDEHYDE
  • 3-METHOXY-4-FLUOROBENZALDEHYDE
  • 4-Fluoro-3-methoxybenzaldehyde ,98%
  • 2-Fluoro-5-formylanisole, 4-Fluoro-m-anisaldehyde
  • 4-Fluoro-M-anisaldehyde, 96.0%(GC)
  • 4-Fluoro-3-methoxybenzaldehyde≥ 98.5% (HPLC)
  • 4-Fluoro-m-anisaldehyde&gt
  • uoro-m-anisaL
  • Benzaldehyde, 4-fluoro-3-methoxy-
  • 4-FLUORO-3-METHOXYBENZALDEHYDE ISO 9001：2015 REACH
  • 3'-Nitro-2,2,3-trifluoroacetophenone
  • 128495-46-5
  • Organic Building Blocks
  • C8
  • Carbonyl Compounds
  • Building Blocks
  • Aldehydes
  • Fluorine series
  • C8
  • Carbonyl Compounds
  • Aryl Fluorinated Building Blocks
  • Building Blocks
  • C7-C8
  • Carbonyl Compounds
  • Chemical Synthesis
  • Fluorinated Building Blocks
  • Organic Building Blocks
  • Organic Fluorinated Building Blocks
  • Other Fluorinated Organic Building Blocks
  • Aromatic Aldehydes & Derivatives (substituted)
  • Benzaldehyde
  • Adehydes, Acetals & Ketones
  • Anisoles, Alkyloxy Compounds & Phenylacetates
  • Fluorine Compounds
  • Aldehydes