ChemicalBook > CAS DataBase List > 4-FLUORO-3-METHOXYBENZALDEHYDE

4-FLUORO-3-METHOXYBENZALDEHYDE

Product Name: 4-FLUORO-3-METHOXYBENZALDEHYDE
CAS No.: 128495-46-5
Chemical Name: 4-FLUORO-3-METHOXYBENZALDEHYDE
Synonyms: uoro-m-anisaL;4-FLUORO-M-ANISALDEHYDE;4-Fluoro-m-anisaldehyde>3-METHOXY-4-FLUOROBENZALDEHYDE;4-FLUORO-3-METHOXYBENZALDEHYDE;4-Fluoro-3-methoxybenzaldehyde97%;Benzaldehyde, 4-fluoro-3-methoxy-;4-Fluoro-3-methoxybenzaldehyde 97%;4-Fluoro-M-anisaldehyde, 96.0%(GC);4-Fluoro-3-methoxybenzaldehyde ,98%
CBNumber: CB7119640
Molecular Formula: C8H7FO2
Formula Weight: 154.14
MOL File: 128495-46-5.mol

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4-FLUORO-3-METHOXYBENZALDEHYDE Property

Melting point:: 58-62 °C(lit.)
Boiling point:: 93 °C(Press: 4.5 Torr)
Density: 1.192±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
color: White to Light yellow
Sensitive: Air Sensitive
BRN: 5178063
InChI: InChI=1S/C8H7FO2/c1-11-8-4-6(5-10)2-3-7(8)9/h2-5H,1H3
InChIKey: NALVGTOMKSKFFV-UHFFFAOYSA-N
SMILES: C(=O)C1=CC=C(F)C(OC)=C1
CAS DataBase Reference: 128495-46-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-37/38-41-36/37/38
Safety Statements: 26-36
WGK Germany: 2
HazardClass: IRRITANT
HS Code: 29124990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 652687
Product name: 4-Fluoro-3-methoxybenzaldehyde
Purity: 97%
Packaging: 5g
Price: $38.57
Updated: 2025/07/31

Sigma-Aldrich

Product number: 652687
Product name: 4-Fluoro-3-methoxybenzaldehyde
Purity: 97%
Packaging: 25g
Price: $237
Updated: 2023/06/20

TCI Chemical

Product number: F0401
Product name: 4-Fluoro-m-anisaldehyde
Purity: >96.0%(GC)
Packaging: 1g
Price: $27
Updated: 2025/07/31

TCI Chemical

Product number: F0401
Product name: 4-Fluoro-m-anisaldehyde
Purity: >96.0%(GC)
Packaging: 5g
Price: $82
Updated: 2025/07/31

TCI Chemical

Product number: F0401
Product name: 4-Fluoro-m-anisaldehyde
Purity: >96.0%(GC)
Packaging: 25g
Price: $247
Updated: 2025/07/31

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4-FLUORO-3-METHOXYBENZALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

White to yellow to tan powder or crystal or crystalline powder

Uses

Synthesis Reference(s)

Journal of Medicinal Chemistry, 33, p. 2408, 1990 DOI: 10.1021/jm00171a014

Synthesis

128495-45-4

128495-46-5

General procedure for the synthesis of 3-methoxy-4-fluorobenzaldehyde from 3-methoxy-4-fluorobenzyl alcohol: (4-fluoro-3-methoxyphenyl)methanol (5.00 g, 0.03 mol) was mixed with manganese dioxide (33.4 g, 0.38 mol) in dichloromethane (100 mL) under nitrogen protection, and the reaction was stirred for 16 hr under mild reflux conditions. Upon completion of the reaction, the reaction mixture was cooled to room temperature, filtered through Arbacel, and the filtrate was concentrated in vacuum to afford 3-methoxy-4-fluorobenzaldehyde (4.18 g, 0.027 mol, 85% yield) as a white solid. The product was characterized by 1H NMR (CDCl3, 400 MHz): δ 3.96 (s, 3H), 7.23 (d, 1H), 7.43 (m, 1H), 7.50 (d, 1H), 9.91 (s, 1H). The melting point is 61-63°C. Elemental analysis results: measured value C, 62.18; H, 4.54%. Theoretical value (C8H7FO2): C, 62.34; H, 4.58%.

References

[1] Journal of Medicinal Chemistry, 1990, vol. 33, # 9, p. 2408 - 2412
[2] Patent: WO2004/52372, 2004, A1. Location in patent: Page 72
[3] Patent: WO2008/87512, 2008, A1. Location in patent: Page/Page column 43
[4] Patent: EP2862571, 2015, A1. Location in patent: Paragraph 0164; 0165
[5] Patent: US2015/166559, 2015, A1. Location in patent: Paragraph 0220; 0221

4-FLUORO-3-METHOXYBENZALDEHYDE Preparation Products And Raw materials

Raw materials

Acetone Diethyl ether Ethyl acetate Dichloromethane Potassium permanganate 2-FLUORO-5-METHYLPHENOL PETROLEUM ETHER Sulfuric acid Dimethyl sulfate

Preparation Products

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4-FLUORO-3-METHOXYBENZALDEHYDE Suppliers

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View Lastest Price from 4-FLUORO-3-METHOXYBENZALDEHYDE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-FLUORO-3-METHOXYBENZALDEHYDE 128495-46-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-06

Henan Bao Enluo International TradeCo.，LTD

Product: 4-FLUORO-3-METHOXYBENZALDEHYDE 128495-46-5
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10000MT
Release date: 2023-08-08

Career Henan Chemical Co

Product: 4-FLUORO-3-METHOXYBENZALDEHYDE 128495-46-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 200KG
Release date: 2018-08-19

128495-46-5, 4-FLUORO-3-METHOXYBENZALDEHYDERelated Search:

4-FLUORO-3-METHOXYBENZALDEHYDE 4-FLUORO-3-METHOXYBENZOIC ACID 4-FLUORO-3-METHOXYACETOPHENONE 3-Methoxy-2,4,5-trifluorobenzoic acid 3-METHOXY-2,4,5-TRIFLUOROBENZAMIDE Levofloxacin carboxylic acid 2,4-DIFLUORO-3-METHOXYBENZALDEHYDE 2,4,5-Trifluoro-3-methoxybenzoyl chloride 4-Fluoro-3-phenoxybenzaldehyde 2,4-Difluoro-3-methoxybenzoic acid 2,4-DIFLUORO-3-METHOXY ACETOPHENONE 6-CHLORO-2-FLUORO-3-METHOXYBENZALDEHYDE 3-CHLORO-5-FLUORO-4-METHOXYBENZALDEHYDE 2-FLUORO-4-METHOXYBENZALDEHYDE,2-Fluoro-4-methoxybenzaldehyde 97%,2-Fluoro-4-methoxybenzaldehyde97% 3-Fluoro-5-methoxybenzaldehyde 97%,3-Fluoro-5-methoxybenzaldehyde97% 3-FLUORO-4-METHOXYBENZALDEHYDE,3-Fluoro-4-Methoxybenzaldehyde/3-Fluoro-P-Anisaldehyde/M-Fluoro-P-Anisaldehyde/ 2-FLUORO-5-METHOXYBENZALDEHYDE,2-Fluoro-5-methoxybenzaldehyde 98%,2-Fluoro-5-methoxybenzaldehyde98% 4-FLUORO-2-METHOXYBENZALDEHYDE

4-Fluoro-3-methoxybenzaldehyde 97%

4-Fluoro-3-methoxybenzaldehyde97%

4-FLUORO-M-ANISALDEHYDE

4-FLUORO-3-METHOXYBENZALDEHYDE

3-METHOXY-4-FLUOROBENZALDEHYDE

4-Fluoro-3-methoxybenzaldehyde ,98%

2-Fluoro-5-formylanisole, 4-Fluoro-m-anisaldehyde

4-Fluoro-M-anisaldehyde, 96.0%(GC)

4-Fluoro-3-methoxybenzaldehyde≥ 98.5% (HPLC)

4-Fluoro-m-anisaldehyde&gt

uoro-m-anisaL

Benzaldehyde, 4-fluoro-3-methoxy-

4-FLUORO-3-METHOXYBENZALDEHYDE ISO 9001：2015 REACH

3'-Nitro-2,2,3-trifluoroacetophenone

128495-46-5

Organic Building Blocks

Carbonyl Compounds

Building Blocks

Aldehydes

Fluorine series

Carbonyl Compounds

Aryl Fluorinated Building Blocks

Building Blocks

C7-C8

Carbonyl Compounds

Chemical Synthesis

Fluorinated Building Blocks

Organic Building Blocks

Organic Fluorinated Building Blocks

Other Fluorinated Organic Building Blocks

Aromatic Aldehydes & Derivatives (substituted)

Benzaldehyde

Adehydes, Acetals & Ketones

Anisoles, Alkyloxy Compounds & Phenylacetates

Fluorine Compounds

Aldehydes