ChemicalBook > CAS DataBase List > O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine

Product Name: O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine
CAS No.: 6723-30-4
Chemical Name: O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine
Synonyms: )-hydroxyL;O-(Tetrahydropyran-2-yL;O-(oxan-2-yl)hydroxylaMine;2-(Aminooxy)tetrahydro-2H-pyran;O-2-tetrahydro-2H-pyranhydroxylamine;O-(TETRAHYDRO-PYRAN-2-YL)-HYDROXYLAMINE;O-tertrahydroxy-pyran-2-yl-hydroxylamine;O-(2H-Tetrahydropyran-2-yl)hydroxylamine;O-(TETRAHYDRO-2H-PYRAN-2-YL)HYDROXYLAMINE;O-(Tetrahydropyran-2-yl)hydroxylamine, 96%,
CBNumber: CB8452849
Molecular Formula: C5H11NO2
Formula Weight: 117.15
MOL File: 6723-30-4.mol

Less

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine Property

Melting point:: 34-37 °C (lit.)
Boiling point:: 81 °C/20 mmHg (lit.)
Density: 1.1274 (rough estimate)
refractive index: 1.4206 (estimate)
Flash point:: 180 °F
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 3.28±0.20(Predicted)
form: Low Melting Solid
color: White
InChI: InChI=1S/C5H11NO2/c6-8-5-3-1-2-4-7-5/h5H,1-4,6H2
InChIKey: NLXXVSKHVGDQAT-UHFFFAOYSA-N
SMILES: NOC1OCCCC1

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29329990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 480894
Product name: O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine
Purity: 96%
Packaging: 1g
Price: $80.5
Updated: 2025/07/31

TCI Chemical

Product number: T2598
Product name: O-(Tetrahydropyran-2-yl)hydroxylamine
Purity: >98.0%(GC)
Packaging: 1g
Price: $19
Updated: 2025/07/31

TCI Chemical

Product number: T2598
Product name: O-(Tetrahydropyran-2-yl)hydroxylamine
Purity: >98.0%(GC)
Packaging: 5g
Price: $48
Updated: 2025/07/31

TRC

Product number: T889565
Product name: O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine
Packaging: 1g
Price: $70
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK560184
Product name: O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine
Purity: 97%
Packaging: 1g
Price: $71
Updated: 2021/12/16

Less

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine can be used to treat fibrotic and inflammatory diseases.

Uses

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine is used as an oximation reagent in the synthesis of a marine alkaloid which shows significant inhibitory activity against mycothiol S-conjugate amidase.

General Description

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine (OTX) is an O-substituted hydroxylamine. The coupling of OTX with alkaline gel electrophoresis has been reported to improve the process of detecting single strand breaks (SSBs) in DNA.

Synthesis

110-87-2

6723-30-4

General procedure for the synthesis of O-(tetrahydro-2H-pyran-2-yl)hydroxylamine from 3,4-dihydro-2H-pyran: N-hydroxyphthalimide (10 g, 0.061 mol) and 3,4-dihydro-2H-pyran (6.1 g, 0.073 mol) were added to a 250 mL three-necked flask, and tetrahydrofuran (100 mL) was added to dissolve. Subsequently, p-toluenesulfonic acid (1.1 g, 6.1 mmol) was added to catalyze the reaction. The reaction was carried out at room temperature for 2 hours. Upon completion of the reaction, the tetrahydrofuran was removed by distillation under reduced pressure. Water (200 mL) was added to the residue and extracted with dichloromethane (3 x 200 mL). The organic phases were combined and washed sequentially with saturated aqueous NaHCO3 solution (3 x 200 mL) and saturated aqueous NaCl solution (200 mL). The organic phase was dried over anhydrous sodium sulfate, filtered and evaporated to dryness to give a yellow-green solid (15.3 g). The resulting solid was transferred to a 1000 mL three-necked flask and ethanol (450 mL) was added and stirred to dissolve. 80% hydrazine hydrate (10.4 mL, 0.17 mol) was slowly added dropwise and the reaction was carried out for 1 hour at room temperature. The reaction solution was directly filtrated and the filtrate was evaporated to give the crude product (10.6 g). The crude product was dissolved with ethyl acetate (500 mL), mixed thoroughly and vacuum filtered to remove insoluble matter. The filtrate was washed with water (3×100 mL) and saturated NaCl aqueous solution (200 mL) sequentially, dried with anhydrous sodium sulfate and filtered, evaporated to dryness to obtain a light yellow oil. The oily material was dried under vacuum to give a yellow solid (5.39 g) with a melting point of 35-37 °C and a yield of 75.3%.

References

[1] Organic Letters, 2006, vol. 8, # 18, p. 4035 - 4038
[2] Patent: CN107400131, 2017, A. Location in patent: Paragraph 0031; 0063-0065
[3] Journal of Medicinal Chemistry, 1996, vol. 39, # 21, p. 4197 - 4210
[4] Patent: WO2012/96832, 2012, A2
[5] Chemical and Pharmaceutical Bulletin, 2014, vol. 62, # 2, p. 168 - 175

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine Preparation Products And Raw materials

Raw materials

Preparation Products

Less

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine Suppliers

China 171 Europe 2 Germany 3 India 8 Japan 1 Switzerland 1 United Kingdom 5 United States 27 Global 218

Zhengzhou Kingsfine Chemical Co., Ltd.

Tel: 0371-56632527 13838252817
Fax: 0371-56635027
Email: sales@kingsfine.com
Country: China
ProdList: 98
Advantage: 62

Suzhou Highfine Biotech Co., Ltd

Tel: 0512-69209928 18796809688
Email: zhouyingxiang@highfine.com
Country: China
ProdList: 1356
Advantage: 58

Creasyn Finechem(Tianjin) Co., Ltd.

Tel: 022-83946278 13820503911
Fax: 022-83945176
Email: sales@creasyn.com
Country: China
ProdList: 957
Advantage: 68

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Changzhou Standard Chemicals Ltd.

Tel: 0519-85607885 13776800733
Fax: +86 519 8552788
Email: email@standardschem.com
Country: China
ProdList: 114
Advantage: 62

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

Wuhan Haizheng Industry & Trade Development Co. Ltd

Tel: 027-8866 0053/88660577/88660578
Fax: 027-8899 1911
Country: China
ProdList: 1073
Advantage: 55

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
Advantage: 55

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Suzhou Sibian Chemical Technology Co.,Ltd.

Tel: 0512-65617459 18915409046
Fax: 0512-65617459
Email: sales@sibian-chem.com
Country: China
ProdList: 1922
Advantage: 55

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
Advantage: 55

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

Huainan Kedi Chemical Factory

Tel: 0554-2106669
Fax: 0554-2666215
Email: sales1@kedichem.com
Country: China
ProdList: 4924
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Zhengzhou HongSheng Pharmaceutical Co., Ltd.

Tel: 0371-0371-13526885213 15637198702
Fax: 0371-63709726
Email: hsyykjchem@163.com
Country: China
ProdList: 3853
Advantage: 58

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
Advantage: 58

Credit-Chem Co., Ltd.

Tel: 400-821-5857 021-64326257
Fax: 021-64393586 QQ;2798200800
Email: credit-chem@foxmail.com
Country: China
ProdList: 5219
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 14912
Advantage: 59

Shanghai Song Yuan Chemical Technology Co., Ltd.

Tel: 010-1234567 18521000990
Fax: 86-021-33275113
Email: sonyuanchemical@163.com
Country: China
ProdList: 6479
Advantage: 50

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Quzhou Rundong Chemical (Technology) Co.

Tel: 0570-8789886 18892685668
Fax: 0570-8789985
Email: info@rundongchemical.com
Country: China
ProdList: 4053
Advantage: 60

Chengdu RunZeBenTu Chemical Co., Ltd

Tel: 028-88469284 18000562381
Email: rzbtsj@163.com
Country: China
ProdList: 9951
Advantage: 56

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Chengdu DingDang Pharmaceutical Co., Ltd.

Tel: 028-86040038 13980902949;
Fax: 028-85149890
Email: market@dingdangchem.com
Country: China
ProdList: 1853
Advantage: 55

ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9627
Advantage: 58

Henan CoreyChem Co., Ltd

Tel: 0371-86658258
Fax: 0371-60996044
Email: info@coreychem.com
Country: China
ProdList: 10453
Advantage: 58

Less

View Lastest Price from O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine 6723-30-4
Price: US $1.00-4.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2025-09-05

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: O-(Tetrahydropyran-2-yl)-hydroxylamine 6723-30-4
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 100KG
Release date: 2025-08-20

Henan Aochuang Chemical Co.,Ltd.

Product: O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine 6723-30-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

6723-30-4, O-(Tetrahydro-2H-pyran-2-yl)hydroxylamineRelated Search:

HYDROXYLAMINE Centchroman Ammonium bicarbonate Tetrahydro-4H-pyran-4-one (S)-(-)-2-Methyl-2-propanesulfinamide N-ISOPROPYL-2-NITROBENZENESULPHONAMIDE N-Acetylethylenediamine N-Acetyltyramine N-ISOPROPYL-4-NITRO-BENZENESULFONAMIDE FMOC-O-ETHYL-L-TYROSINE MINOXIDIL GLUCURONIDE Nicotine N-β-D-Glucuronide esperamicin A1 CNG Trichostatin C BETA-GAL-NONOATE N-(TETRAHYDRO-2H-PYRAN-2-YLOXY)SUCCINIMIDE Suberoylanilide Hydroxamic Acid b-D-Glucuronide

HYDROXYLAMINE, O-(TETRAHYDRO-2H-PYRAN-2-YL)-

O-(TETRAHYDRO-2H-PYRAN-2-YL)HYDROXYLAMINE

O-(TETRAHYDRO-PYRAN-2-YL)-HYDROXYLAMINE

O-(2H-Tetrahydropyran-2-yl)hydroxylamine

O-tertrahydroxy-pyran-2-yl-hydroxylamine

2-(Aminooxy)tetrahydro-2H-pyran

O-(oxan-2-yl)hydroxylaMine

O-(Tetrahydropyran-2-yl)-hydroxylaMine, 95+%

O-(Tetrahydropyran-2-yl)hydroxylamine

O-(Tetrahydropyran-2-yl)hydroxylamine≥ 98%(GC)

O-(Tetrahydropyran-2-yL

)-hydroxyL

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine ISO 9001：2015 REACH

O-(Tetrahydropyran-2-yl)hydroxylamine, 96%,

O-2-tetrahydro-2H-pyranhydroxylamine

O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine

O-(Tetrahydro-2H-pyran-2-yl) hydroxylamine, 98%min

6723-30-4

Heterocyclic Building Blocks

Pyrans

Building Blocks

Chemical Synthesis

Heterocyclic Building Blocks

Building Blocks

Heterocyclic Building Blocks

Pyrans