(S)-(-)-2-Methyl-2-propanesulfinamide

Description

Product Name: (S)-(-)-2-Methyl-2-propanesulfinamide
CAS No.: 343338-28-3
Chemical Name: (S)-(-)-2-Methyl-2-propanesulfinamide
Synonyms: (S)-2-METHYLPROPANE-2-SULFINAMIDE;TERT-BUTYL SULFINAMIDE;(S)-(-)-T-BUTYLSULFINAMIDE;S-BSN;finamide;Suprabasin;S-tert-butylsulfonamide;S- tert butyl sulfenaMide;Brilanestrant Impurity 10;(S)-(-)-TERT-BUTYLSULFINAMIDE
CBNumber: CB0209955
Molecular Formula: C4H11NOS
Formula Weight: 121.2
MOL File: 343338-28-3.mol

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(S)-(-)-2-Methyl-2-propanesulfinamide Property

Melting point:: 97-101 °C(lit.)
alpha: -4.5 º (c=1, CHCl3)
Boiling point:: 220.0±23.0 °C(Predicted)
Density: 1.124
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 10.11±0.50(Predicted)
form: Crystalline Powder
color: White
optical activity: [α]20/D 4.5°, c = 1 in chloroform
Stability:: store cold
InChI: InChI=1/C4H11NOS/c1-4(2,3)7(5)6/h5H2,1-3H3/t7-/s3
InChIKey: CESUXLKAADQNTB-SSDOTTSWSA-N
SMILES: CC(C)([S@@](N)=O)C |&1:3,r|
CAS DataBase Reference: 343338-28-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn,F
Risk Statements: 11-19-36/37-40
Safety Statements: 16-26-36/37-24/25
WGK Germany: 3
Hazard Note: Irritant/Keep Cold
TSCA: No
HS Code: 29309090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 513210
Product name: (S)-(?)-2-Methyl-2-propanesulfinamide
Purity: 97%
Packaging: 1g
Price: $50.82
Updated: 2024/03/01

Sigma-Aldrich

Product number: 513210
Product name: (S)-(?)-2-Methyl-2-propanesulfinamide
Purity: 97%
Packaging: 5g
Price: $228
Updated: 2024/03/01

TCI Chemical

Product number: B2908
Product name: (S)-(-)-tert-Butylsulfinamide
Purity: >98.0%(GC)
Packaging: 1g
Price: $50
Updated: 2024/03/01

TCI Chemical

Product number: B2908
Product name: (S)-(-)-tert-Butylsulfinamide
Purity: >98.0%(GC)
Packaging: 5g
Price: $175
Updated: 2024/03/01

Alfa Aesar

Product number: H27115
Product name: (S)-(-)-2-Methyl-2-propanesulfinamide, 97%
Packaging: 1g
Price: $76.65
Updated: 2024/03/01

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(S)-(-)-2-Methyl-2-propanesulfinamide Chemical Properties,Usage,Production

Description

Acid labile protecting groups are important in organic synthesis. The tert‐butyl group is commonly used for protection of a large variety of functional groups, e.g., acids, alcohols, phenols, and sulfonamides. Among them, s-tert-butyl sulfonamide is a chiral ligand used in pharmaceutical compositions. P, n-sulfoxide imine ligands were synthesized by condensation of s-tert-butylsulfonamide with aldehydes and ketones, and they can be used for asymmetric hydrogenation of olefins under iridium catalysis.

Physical properties

white to light yellow crystal powder

Uses

(S)-(-)-2-Methyl-2-propanesulfinamide may be used to develop benzofuran-based farnesyltransferase inhibitors as anti-cancer agents. It may also be used to prepare (20E)-N-[t-butyl-(S)-sulfinyl]-3β-(t-butyldimethylsilyloxy)-pregn-5-en-20-imine, an intermediate for the preparation of androgen receptor antagonists.

Uses

(S)-(-)-2-Methyl-2-propanesulfinamide is used in Suzuki reaction. It is also employed as a reagent for synthesizing chiral amines. It acts as a chiral auxiliary used in an asymmetric synthesis of trifluoroethylamines by conversion of trifluoroacetaldehyde to a chiral imine. It is also involved in the transformation of P,N-sulfinyl imine ligands through condensation with aldehydes and ketones, which can undergo iridium-catalyzed asymmetric hydrogenation of olefins. Further, it serves as a reagent for the preparation of chemicals and pharmaceutical intermediates.

(S)-(-)-2-Methyl-2-propanesulfinamide Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(-)-2-Methyl-2-propanesulfinamide Suppliers

Americas 1 Belgium 2 Canada 3 China 357 Europe 3 France 2 Germany 4 India 11 Japan 1 Switzerland 1 United Kingdom 16 United States 56 Global 457

Shanghai Arbor Chemical Co., Ltd.

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INTATRADE GmbH

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View Lastest Price from (S)-(-)-2-Methyl-2-propanesulfinamide manufacturers

Shanghai UCHEM Inc.

Product: (S)-(-)-2-Methyl-2-propanesulfinamide 343338-28-3
Price: US $10.00-90.00/g
Min. Order: 5g
Purity: 0.98
Supply Ability: 25kg
Release date: 2023-12-11

Hebei Yanxi Chemical Co., Ltd.

Product: 2-methylpropane-2-sulfinamide 343338-28-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100tons
Release date: 2023-09-05

Hebei Guanlang Biotechnology Co., Ltd.

Product: (S)-(-)-2-Methyl-2-propanesulfinamide 343338-28-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2022-09-28

343338-28-3, (S)-(-)-2-Methyl-2-propanesulfinamideRelated Search:

N-BENZYLQUININIUM CHLORIDE TERT-BUTYLSULFONAMIDE (R)-(+)-2-METHYL-2-PROPANESULFINAMIDE,(R)-2-METHYL-2-PROPANESULFINAMIDE Trimethoprim tert-Butanol Silver sulfate Boric acid (R)-(+)-4-Isopropyl-2-oxazolidinone (R)-(-)-4-Phenyl-2-oxazolidinone (4S)-(-)-4-Isopropyl-2-oxazolidinone (R)-4-Benzyl-2-oxazolidinone (S)-4-Benzyl-2-oxazolidinone (S)-(+)-4-Phenyl-2-oxazolidinone Di-tert-butylphosphine Tri-tert-butylphosphine Thionyl chloride Triisopropyl borate N-ISOPROPYL-2-NITROBENZENESULPHONAMIDE

2-METHYL-2-PROPANE-SULFINAMIDE(S-ISOMER)

(S)-tert-Butylsulfinamide, (>98.0% ee), 97+%

(S)-(-)-2-METHYL-2-PROPANESULPHINAMIDE

(S)-2-METHYLPROPANE-2-SULFINAMIDE

(S)-(-)-2-METHYL-PROPANE-2-SULFINIC ACID AMIDE

(S)-(-)-TERT-BUTYLSULFINAMIDE

(S)-(-)-TERT-BUTYL SULPHINAMIDE

(S)-(-)-T-BUTYLMETHYLSULFINAMIDE

(S)-(-)-2-Methylpropane-2-sulphinamide 98%

[S(S)]-2-Methyl-2-propanesulfinaMide

2-PropanesulfinaMide, 2-Methyl-, [S(S)]-

S-BSN

S- tert butyl sulfenaMide

(S)-tert-Butylsulfinamide (S)-(-)-2-Methyl-2-propanesulfinamide

(S)-(?)-2-Methyl-2-propanesulfinamide solution

ANTI-SBSN (N-TERM) antibody produced in rabbit

Suprabasin

(S)-(-)-<i>tert</i>-Butylsulfinamide

(S)-(-)-2-Methyl-2-propanesulfinamide 97%

Amino(tert-butyl)sulfaniumolate

(S)-(-)-t-Butylsulfinamide, min. 97%

(S)-TERT-BUTANESULFINAMIDE / (S)-(-)-2-METHYL-2-P

(S)-(-)-2-Methyl-2-propanesulfimide

(S)-2-Methyl-2-propanesulfinamide,99%e.e.

S-tert-butylsulfonamide

(S)-(-)-T-BUTYLSULFINAMIDE

TERT-BUTYL SULFINAMIDE

(S)-(-)-t-Butylmethylsulfinamide,min.97%

(S)-(-)-tert-Butyl sulphinamide 98%

(S)-(-)-t-Butyl sulfinamide, 98% ee

(S)-TERT-BUTANESULFINAMIDE / (S)-(-)-2-METHYL-2-PROPANESULFINAMIDE

(S)-(-)-2-METHYL-2-PROPANESULFINAMIDE,98.5+%

(S)-TERT-BUTYLSULFINAMIDE,97+% (>98.0% EE)

(S)-(-)-t-Butylmethylsulfinamide, min. 97%

(S)-tert-Butylsulfinamide, (>98.0% ee)

(S)-(-)-2-Methyl-2-propanesulfinamide

(S)-Tert butane sulfonamide 98%

(S)-(-)-2-Methyl-2-propanesulfinaMide(S)-(-)-2-Methyl-2-propanesulfinaMide

finamide

(S)-(-)-tert-Butylsulfinamide &gt

(S)-(-)-tert-Butylsulfinamide, 98%, for synthesis

(S)-(-)-2-Methyl-2-propanesulfinamide USP/EP/BP

Brilanestrant Impurity 10

343338-28-3

343338-27-8

343338-28-2

3423338-28-3

C3H11CNOS

C4H9CH3SONH2

C4H11NOS

Organic Building Blocks

Sulfur-Based

Sulfur Compounds

Sulfonamides/Sulfinamides

Building Blocks

Asymmetric Synthesis

Chiral Auxiliaries

Asymmetric Synthesis