2-AMINO-4,6-DICHLOROPHENOL

Product Name: 2-AMINO-4,6-DICHLOROPHENOL
CAS No.: 527-62-8
Chemical Name: 2-AMINO-4,6-DICHLOROPHENOL
Synonyms: 2,4-Dichloro-6-amino;2-Amino-4,6-chlorophenol;4,6-Dichloro-α-aminophenol;4,6-Dichloro-2-aminophenol;4,6-Dichloro-o-aminophenol;2-AMINO-4,6-DICHLOROPHENOL;2,4-DICHLORO-6-AMINOPHENOL;2-amino-4,6-dichloro-pheno;6-AMINO-2,4-DICHLORO PHENOL;3,5-Dichloro-2-hydroxyaniline
CBNumber: CB8454151
Molecular Formula: C6H5Cl2NO
Formula Weight: 178.02
MOL File: 527-62-8.mol

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2-AMINO-4,6-DICHLOROPHENOL Property

Melting point:: 97 °C
Boiling point:: 286.5±40.0 °C(Predicted)
Density: 1.2549 (rough estimate)
refractive index: 1.5680 (estimate)
RTECS: SJ5774000
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 7.85±0.23(Predicted)
form: Solid
color: Yellow to brown
Merck: 14,437
CAS DataBase Reference: 527-62-8(CAS DataBase Reference)
EPA Substance Registry System: 2-Amino-4,6-dichlorophenol (527-62-8)

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Safety

Hazard Note: Irritant
HazardClass: 6.1
HS Code: 2922290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2246
Product name: 2-Amino-4,6-dichlorophenol
Purity: >98.0%(T)
Packaging: 5g
Price: $48
Updated: 2021/12/16

TCI Chemical

Product number: A2246
Product name: 2-Amino-4,6-dichlorophenol
Purity: >98.0%(T)
Packaging: 25g
Price: $158
Updated: 2021/12/16

TRC

Product number: A637173
Product name: 2-Amino-4,6-dichlorophenol
Packaging: 5g
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: J50941
Product name: 2-Amino-4,6-dichlorophenol
Packaging: 1g
Price: $21
Updated: 2021/12/16

Matrix Scientific

Product number: 074286
Product name: 2,4-Dichloro-6-aminophenol
Purity: 95+%
Packaging: 10g
Price: $23
Updated: 2021/12/16

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2-AMINO-4,6-DICHLOROPHENOL Chemical Properties,Usage,Production

Chemical Properties

Off-white or light brown crystals

Uses

2-Amino-4,6-dichlorophenol is used in preparation of novel heteroaryl-substituted Aminoalkyl Azole compounds as pesticides.

General Description

Long needles (from carbon disulfide). Sublimes (at 0.06 mm Hg) at 158-176°F.

Air & Water Reactions

May be sensitive to prolonged exposure to air/or light.

Reactivity Profile

2-AMINO-4,6-DICHLOROPHENOL may react with strong oxidizers and mineral acids or bases .

Fire Hazard

Flash point data for 2-AMINO-4,6-DICHLOROPHENOL are not available. 2-AMINO-4,6-DICHLOROPHENOL is probably combustible.

Synthesis

609-89-2

527-62-8

General procedure for the synthesis of 2,4-dichloro-6-aminophenol from 2,4-dichloro-6-nitrophenol: To a suspension of 2,4-dichloro-6-nitrophenol (60.0 g, 288 mmol) in ethanol (250 mL) and water (250 mL) was added sodium bisulfite (251 g, 1.44 mol) in batches. The reaction mixture was stirred at 65 °C for 4 hours. Upon completion of the reaction, the mixture was concentrated under vacuum and subsequently diluted with saturated aqueous sodium bicarbonate (500 mL) and extracted with ethyl acetate (200 mL x 4). The extracted organic layer was washed with brine and then dried with anhydrous magnesium sulfate. The dried organic layer was filtered and concentrated in vacuum. The residue was purified by silica gel EPO fast column chromatography with an eluent of 0-50% ethyl acetate/hexane gradient mixture. The target fractions were collected and the filtrate was concentrated in vacuum to give a solid product. The solid was washed with hexane to give a final 2,4-dichloro-6-aminophenol (30.6 g, 172 mmol, 60% yield) as a colorless powder. The product was confirmed by 1H NMR (CDCl3): δ 3.92 (s, 2H), 5.36 (s, 1H), 6.59 (d, J = 2.1Hz, 1H), 6.71 (d, J = 2.1Hz, 1H). Results of mass spectrometry analysis: MS Calcd.: 177; MS measured value: 178 (M + H).

Purification Methods

Crystallise the phenol from CS2 or *benzene. It sublimes at 0.06mm. The hydrochloride has m 280-285o from EtOH. [Meyer Helv Chim Acta 41 1890 1958, Beilstein 13 II 185, 13 III 856, 13 IV 889.]

References

[1] Liebigs Annalen der Chemie, 1994, # 3, p. 269 - 276
[2] Bioorganic and Medicinal Chemistry Letters, 1998, vol. 8, # 14, p. 1923 - 1928
[3] Patent: WO2008/51533, 2008, A2. Location in patent: Page/Page column 79-80
[4] Patent: US2002/156081, 2002, A1
[5] Patent: US6921763, 2005, B2

2-AMINO-4,6-DICHLOROPHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-4,6-DICHLOROPHENOL Suppliers

Americas 1 Belgium 1 Canada 1 China 114 Europe 2 France 2 Germany 3 India 26 Japan 1 Slovakia 1 South Korea 1 United Kingdom 15 United States 25 Global 193

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View Lastest Price from 2-AMINO-4,6-DICHLOROPHENOL manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: 2-Amino-4,6-dichlorophenol 527-62-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 1000kg
Release date: 2023-10-08

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Amino-4,6-dichlorophenol 527-62-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-02-18

Career Henan Chemical Co

Product: 2-AMINO-4,6-DICHLOROPHENOL 527-62-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-24

527-62-8, 2-AMINO-4,6-DICHLOROPHENOLRelated Search:

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2-Amino-4,6-dichlorophenol, CAS 527-62-8

527-62-8

C6H5NOCl2

C6H5Cl2NO

Aromatic Phenols