2-AMINO-4,6-DICHLOROPHENOL
- Product Name
- 2-AMINO-4,6-DICHLOROPHENOL
- CAS No.
- 527-62-8
- Chemical Name
- 2-AMINO-4,6-DICHLOROPHENOL
- Synonyms
- 2,4-Dichloro-6-amino;2-Amino-4,6-chlorophenol;4,6-Dichloro-α-aminophenol;4,6-Dichloro-2-aminophenol;4,6-Dichloro-o-aminophenol;2-AMINO-4,6-DICHLOROPHENOL;2,4-DICHLORO-6-AMINOPHENOL;2-amino-4,6-dichloro-pheno;6-AMINO-2,4-DICHLORO PHENOL;3,5-Dichloro-2-hydroxyaniline
- CBNumber
- CB8454151
- Molecular Formula
- C6H5Cl2NO
- Formula Weight
- 178.02
- MOL File
- 527-62-8.mol
2-AMINO-4,6-DICHLOROPHENOL Property
- Melting point:
- 97 °C
- Boiling point:
- 286.5±40.0 °C(Predicted)
- Density
- 1.2549 (rough estimate)
- refractive index
- 1.5680 (estimate)
- RTECS
- SJ5774000
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 7.85±0.23(Predicted)
- form
- Solid
- color
- Yellow to brown
- Merck
- 14,437
- CAS DataBase Reference
- 527-62-8(CAS DataBase Reference)
- EPA Substance Registry System
- 2-Amino-4,6-dichlorophenol (527-62-8)
Safety
- Hazard Note
- Irritant
- HazardClass
- 6.1
- HS Code
- 2922290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A2246
- Product name
- 2-Amino-4,6-dichlorophenol
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $48
- Updated
- 2021/12/16
- Product number
- A2246
- Product name
- 2-Amino-4,6-dichlorophenol
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $158
- Updated
- 2021/12/16
- Product number
- A637173
- Product name
- 2-Amino-4,6-dichlorophenol
- Packaging
- 5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- J50941
- Product name
- 2-Amino-4,6-dichlorophenol
- Packaging
- 1g
- Price
- $21
- Updated
- 2021/12/16
- Product number
- 074286
- Product name
- 2,4-Dichloro-6-aminophenol
- Purity
- 95+%
- Packaging
- 10g
- Price
- $23
- Updated
- 2021/12/16
2-AMINO-4,6-DICHLOROPHENOL Chemical Properties,Usage,Production
Chemical Properties
Off-white or light brown crystals
Uses
2-Amino-4,6-dichlorophenol is used in preparation of novel heteroaryl-substituted Aminoalkyl Azole compounds as pesticides.
General Description
Long needles (from carbon disulfide). Sublimes (at 0.06 mm Hg) at 158-176°F.
Air & Water Reactions
May be sensitive to prolonged exposure to air/or light.
Reactivity Profile
2-AMINO-4,6-DICHLOROPHENOL may react with strong oxidizers and mineral acids or bases .
Fire Hazard
Flash point data for 2-AMINO-4,6-DICHLOROPHENOL are not available. 2-AMINO-4,6-DICHLOROPHENOL is probably combustible.
Synthesis
609-89-2
527-62-8
General procedure for the synthesis of 2,4-dichloro-6-aminophenol from 2,4-dichloro-6-nitrophenol: To a suspension of 2,4-dichloro-6-nitrophenol (60.0 g, 288 mmol) in ethanol (250 mL) and water (250 mL) was added sodium bisulfite (251 g, 1.44 mol) in batches. The reaction mixture was stirred at 65 °C for 4 hours. Upon completion of the reaction, the mixture was concentrated under vacuum and subsequently diluted with saturated aqueous sodium bicarbonate (500 mL) and extracted with ethyl acetate (200 mL x 4). The extracted organic layer was washed with brine and then dried with anhydrous magnesium sulfate. The dried organic layer was filtered and concentrated in vacuum. The residue was purified by silica gel EPO fast column chromatography with an eluent of 0-50% ethyl acetate/hexane gradient mixture. The target fractions were collected and the filtrate was concentrated in vacuum to give a solid product. The solid was washed with hexane to give a final 2,4-dichloro-6-aminophenol (30.6 g, 172 mmol, 60% yield) as a colorless powder. The product was confirmed by 1H NMR (CDCl3): δ 3.92 (s, 2H), 5.36 (s, 1H), 6.59 (d, J = 2.1Hz, 1H), 6.71 (d, J = 2.1Hz, 1H). Results of mass spectrometry analysis: MS Calcd.: 177; MS measured value: 178 (M + H).
Purification Methods
Crystallise the phenol from CS2 or *benzene. It sublimes at 0.06mm. The hydrochloride has m 280-285o from EtOH. [Meyer Helv Chim Acta 41 1890 1958, Beilstein 13 II 185, 13 III 856, 13 IV 889.]
References
[1] Liebigs Annalen der Chemie, 1994, # 3, p. 269 - 276
[2] Bioorganic and Medicinal Chemistry Letters, 1998, vol. 8, # 14, p. 1923 - 1928
[3] Patent: WO2008/51533, 2008, A2. Location in patent: Page/Page column 79-80
[4] Patent: US2002/156081, 2002, A1
[5] Patent: US6921763, 2005, B2
2-AMINO-4,6-DICHLOROPHENOL Preparation Products And Raw materials
Raw materials
Preparation Products
2-AMINO-4,6-DICHLOROPHENOL Suppliers
- Tel
- --
- Fax
- --
- info@hattoricorp.com
- Country
- Japan
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View Lastest Price from 2-AMINO-4,6-DICHLOROPHENOL manufacturers
- Product
- 2-Amino-4,6-dichlorophenol 527-62-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 0.99
- Supply Ability
- 1000kg
- Release date
- 2023-10-08
- Product
- 2-Amino-4,6-dichlorophenol 527-62-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-18
- Product
- 2-AMINO-4,6-DICHLOROPHENOL 527-62-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-24