5-(Trifluoromethyl)nicotinic acid
- Product Name
- 5-(Trifluoromethyl)nicotinic acid
- CAS No.
- 131747-40-5
- Chemical Name
- 5-(Trifluoromethyl)nicotinic acid
- Synonyms
- 5-TRIFLUOROMETHYLINICOTINIC ACID;5-(TRIFLUOROMETHYL)NICOTINIC ACID;5-(Trifluoromethyl)nicotinicacid,97%;5-(trifluoroMethyl)pyridin-3-carboxylic acid;5-(Trifluoromethy)pyridine-3-carboxylic acid;5-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXYLIC ACID;5-(Trifluoromethyl)-3-pyridinecarboxylic acid;3-Pyridinecarboxylicacid, 5-(trifluoromethyl)-;5-(Trifluoromethyl)nicotinic acid ISO 9001：2015 REACH;5-
(TrifluoroMethyl) pyridine- 3- carboxylic acid - CBNumber
- CB8467579
- Molecular Formula
- C7H4F3NO2
- Formula Weight
- 191.11
- MOL File
- 131747-40-5.mol
5-(Trifluoromethyl)nicotinic acid Property
- Melting point:
- 184-189℃
- Boiling point:
- 277.5±40.0 °C(Predicted)
- Density
- 1.484±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Solid
- pka
- 3.04±0.10(Predicted)
- color
- Off-white
N-Bromosuccinimide Price
- Product number
- 753297
- Product name
- 5-(Trifluoromethyl)pyridine-3-carboxylic acid
- Purity
- 95%
- Packaging
- 250mg
- Price
- $78.3
- Updated
- 2023/06/20
- Product number
- T896713
- Product name
- 5-(Trifluoromethyl)nicotinicAcid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC9138
- Product name
- 5-(Trifluoromethyl)nicotinicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $51
- Updated
- 2021/12/16
- Product number
- 4H21-3-Z5
- Product name
- 5-(Trifluoromethyl)nicotinic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $132
- Updated
- 2021/12/16
- Product number
- 034741
- Product name
- 5-(Trifluoromethy)pyridine-3-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $59
- Updated
- 2021/12/16
5-(Trifluoromethyl)nicotinic acid Chemical Properties,Usage,Production
Synthesis
124-38-9
436799-33-6
131747-40-5
The general procedure for synthesizing 5-trifluoromethylnicotinic acid from carbon dioxide and 3-bromo-5-(trifluoromethyl)pyridine is as follows: 1. 1.5 g of 3-bromo-5-(trifluoromethyl)pyridine was dissolved in 50 mL of toluene at -75 °C to prepare a solution. 2. the above solution was slowly added dropwise to a mixed system containing 9.96mL (15.9mmol) 1.6M butyl lithium hexane solution and 3.98mL (8mmol) 2M butyl magnesium chloride ethyl ether solution and 10mL THF. 3. After the dropwise addition was completed, the reaction system was kept at -75°C and continued to be stirred for 20 minutes. 4. Subsequently, 20 g (454 mmol) of dry ice was added to the reaction system and stirring was continued at -75°C for 20 minutes, then brought to room temperature and stirred for 3 hours. 5. Upon completion of the reaction, the reaction mixture was combined with 50 mL of 1 M sodium hydroxide solution and extracted twice with ether. 6. The aqueous phase was acidified to acidity with 4M hydrochloric acid and extracted with ether three times. 7. All organic phases were combined and dried with anhydrous sodium sulfate and subsequently evaporated to dryness under vacuum. 8. The residue was mixed with dichloromethane and the precipitate formed was collected by filtration. 9. Finally, the precipitate was placed in a circulating air dryer and dried at 55 °C to give the target product 5-trifluoromethylnicotinic acid. Yield: 9% based on the theoretical value of C7H4F3NO2 (191.11).
References
[1] European Journal of Organic Chemistry, 2003, # 8, p. 1559 - 1568
[2] Patent: US2010/240669, 2010, A1. Location in patent: Page/Page column 141
5-(Trifluoromethyl)nicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-(Trifluoromethyl)nicotinic acid manufacturers
- Product
- 5-(Trifluoromethyl)pyridine-3-carboxylic acid 131747-40-5
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%
- Supply Ability
- Inquiry
- Release date
- 2023-07-10
- Product
- 5-(Trifluoromethyl)nicotinic acid 131747-40-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.6%
- Supply Ability
- 100 tons
- Release date
- 2022-01-25
- Product
- 5-(Trifluoromethyl)nicotinic acid 131747-40-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-26