AZD 3241

AZD 3241 Property

Density 

1.34±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 10 mg/mL; DMSO: 10 mg/mL; Ethanol: 2 mg/mL

form 

A solid

pka

8.25±0.20(Predicted)

color 

White to light brown

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

AZD 3241 Chemical Properties,Usage,Production

Uses

Verdiperstat (AZD3241) is a selective, irreversible and orally active myeloperoxidase (MPO) inhibitor, with an IC50 of 630 nM, and can be used in the research of neurodegenerative brain disorders.

References

[1] Johnstr?m P, et al. Development of rapid multistep carbon-11 radiosynthesis of the myeloperoxidase inhibitor AZD3241 to assess brain exposure by PET microdosing. Nucl Med Biol. 2015 Jun;42(6):555-60. DOI:10.1016/j.nucmedbio.2015.02.001
[2] Jucaite A, et al. Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease. Brain. 2015 Sep;138(Pt 9):2687-700. DOI:10.1093/brain/awv184