2-AMINO-3-FLUOROPHENOL

Product Name: 2-AMINO-3-FLUOROPHENOL
CAS No.: 53981-23-0
Chemical Name: 2-AMINO-3-FLUOROPHENOL
Synonyms: 2-AMINO-3-FLUOROPHENOL;2-Fluoro-6-hydroxyaniline;Phenol, 2-aMino-3-fluoro-;6-Fluoro-2-hydroxyaniline;2-AMINO-3-FLUOROPHENOL ISO 9001：2015 REACH
CBNumber: CB8480536
Molecular Formula: C6H6FNO
Formula Weight: 127.12
MOL File: 53981-23-0.mol

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2-AMINO-3-FLUOROPHENOL Property

Melting point:: 126-127°
Boiling point:: 221.9±25.0 °C(Predicted)
Density: 1.347±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
form: solid
pka: 8.76±0.10(Predicted)
color: Light yellow to brown
InChI: InChI=1S/C6H6FNO/c7-4-2-1-3-5(9)6(4)8/h1-3,9H,8H2
InChIKey: QOZLOYKAFDTQNU-UHFFFAOYSA-N
SMILES: C1(O)=CC=CC(F)=C1N

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-37/38-41
Safety Statements: 26-39
RIDADR: 2512
HazardClass: IRRITANT
PackingGroup: Ⅲ
HS Code: 2908990000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H228Flammable solid

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

TRC

Product number: A609755
Product name: 2-Amino-3-fluorophenol
Packaging: 5g
Price: $365
Updated: 2021/12/16

Matrix Scientific

Product number: 041030
Product name: 2-Amino-3-fluorophenol
Purity: 98%
Packaging: 5g
Price: $380
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA44991
Product name: 2-Amino-3-fluorophenol
Packaging: 2g
Price: $456
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA44991
Product name: 2-Amino-3-fluorophenol
Packaging: 5G
Price: $660
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0011026
Product name: 2-AMINO-3-FLUOROPHENOL
Purity: 95.00%
Packaging: 1G
Price: $952.88
Updated: 2021/12/16

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2-AMINO-3-FLUOROPHENOL Chemical Properties,Usage,Production

Uses

2-Amino-3-fluorophenol is a reagent that is used in the preparation of benzimidazole- and benzoxazole-pyrimidone selective PI3Kβ inhibitors for the treatment of phosphatase and TENsin homologue (PTEN) deficient cancers.

Synthesis

385-01-3

53981-23-0

Step 1. General procedure for the synthesis of 2-amino-3-fluorophenol from 3-fluoro-2-nitrophenol: Stannous chloride dihydrate (0.724 g, 3.18 mmol) was added to a solution of tetrahydrofuran (THF, 5.0 mL) of 3-fluoro-2-nitrophenol (0.100 g, 0.636 mmol, SynQuest), followed by water ( 5.0 mL). The reaction mixture was heated to 80 °C and maintained for 40 min. After the reaction was completed, it was cooled to room temperature and the reaction mixture was diluted with ethyl acetate and saturated sodium bicarbonate solution. The insoluble material was removed by filtration and the organic and aqueous layers were separated. The aqueous layer was extracted three times with ethyl acetate. The combined organic extracts were washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated to give the crude product 2-amino-3-fluorophenol (65 mg, 80% yield), which could be used in the subsequent reaction without further purification.LCMS (M + H)+: 128.0.

References

[1] ChemMedChem, 2017, vol. 12, # 17, p. 1436 - 1448
[2] Journal of Labelled Compounds and Radiopharmaceuticals, 2006, vol. 49, # 7, p. 623 - 634
[3] Patent: US5886044, 1999, A
[4] Patent: US5780483, 1998, A
[5] Patent: US6262113, 2001, B1

2-AMINO-3-FLUOROPHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-3-FLUOROPHENOL Suppliers

China 111 India 1 Switzerland 1 United Kingdom 3 United States 8 Global 124

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View Lastest Price from 2-AMINO-3-FLUOROPHENOL manufacturers

Career Henan Chemical Co

Product: 2-AMINO-3-FLUOROPHENOL 53981-23-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200kgs
Release date: 2020-01-10

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2-AMINO-3-FLUOROPHENOL

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2-Fluoro-6-hydroxyaniline

2-AMINO-3-FLUOROPHENOL ISO 9001：2015 REACH

53981-23-0

53891-23-0

Fluorine series