3,4-Dihydro-7-(4-bromobutoxy)-2(1H)-quinolinone

Product Name: 3,4-Dihydro-7-(4-bromobutoxy)-2(1H)-quinolinone
CAS No.: 129722-34-5
Chemical Name: 3,4-Dihydro-7-(4-bromobutoxy)-2(1H)-quinolinone
Synonyms: CL041;Aripiprazol Intermediate;Aripiprazole Impurity i;Aripiprazole impurities1775;7-(4-bromobutoxy)-3,4-dihydro-;7-(4-BROMOBUTOXY)-3 4-DIHYDROCARBOSTYRYL;Aripiprazole Bromobutoxyquinoline Impurity;7-(4-BROMOBUTOXY)-3,4-DIHYDRO-2-QUINOLINONE;7-(4-Brombutoxy)-3,4-dihydrochinolin-2(1H)-on;7-(4-Bromobutoxy)-2(1h)-3,4-Dihydroquinolinone
CBNumber: CB8481674
Molecular Formula: C13H16BrNO2
Formula Weight: 298.18
MOL File: 129722-34-5.mol

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3,4-Dihydro-7-(4-bromobutoxy)-2(1H)-quinolinone Property

Melting point:: 110-111°C
Boiling point:: 463.4±45.0 °C(Predicted)
Density: 1.383±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 14.41±0.20(Predicted)
form: powder to crystal
color: White to Almost white
Stability:: Hygroscopic
InChI: InChI=1S/C13H16BrNO2/c14-7-1-2-8-17-11-5-3-10-4-6-13(16)15-12(10)9-11/h3,5,9H,1-2,4,6-8H2,(H,15,16)
InChIKey: URHLNHVYMNBPEO-UHFFFAOYSA-N
SMILES: N1C2=C(C=CC(OCCCCBr)=C2)CCC1=O
CAS DataBase Reference: 129722-34-5(CAS DataBase Reference)

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Safety

HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B3333
Product name: 7-(4-Bromobutoxy)-3,4-dihydro-2(1H)-quinolinone
Purity: >98.0%(HPLC)(N)
Packaging: 1g
Price: $37
Updated: 2025/07/31

TCI Chemical

Product number: B3333
Product name: 7-(4-Bromobutoxy)-3,4-dihydro-2(1H)-quinolinone
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $113
Updated: 2025/07/31

TRC

Product number: B681960
Product name: 7-(4-Bromobutoxy)-3,4-dihydroquinolin-2-one
Packaging: 10g
Price: $215
Updated: 2021/12/16

TRC

Product number: B681960
Product name: 7-(4-Bromobutoxy)-3,4-dihydroquinolin-2-one
Packaging: 100g
Price: $1165
Updated: 2021/12/16

Ark Pharm

Product number: P000607276
Product name: 7-(4-Bromobutoxy)-3,4-dihydroquinolin-2(1H)-one
Purity: 97%
Packaging: 250mg
Price: $5
Updated: 2021/12/16

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3,4-Dihydro-7-(4-bromobutoxy)-2(1H)-quinolinone Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

An impurity in the synthesis of Aripiprazole (A771000). A degradation product in Aripiprazole tablets.

Synthesis

110-52-1

22246-18-0

129722-34-5

Example-1: Preparation of 7-(4-bromobutoxy)-3,4-dihydroquinolone [BBQ] was carried out as follows: in a 3-liter, three-necked, round-bottomed flask equipped with a mechanical stirrer, a condenser, and a thermometer, 100 grams of 3,4-dihydro-7-hydroxy-2(1H)-quinolone, 397.5 grams of 1,4-dibromobutane, 42.33 grams of potassium carbonate, and 300 ml of N,N-dimethylformamide. After mixing with stirring at room temperature (30-35 °C), the reaction mixture was heated to 40-45 °C and maintained at this temperature for 1 hour. Subsequently, a second batch of potassium carbonate (42.33 g) was added and the reaction was continued at 40-45 °C for 1 hour. Next, a third batch of potassium carbonate (42.33 g) was added and the reaction was continued at the same temperature for 4-5 hours. After completion of the reaction, the mixture was cooled to room temperature, poured into 1500 ml of water and stirred for 30 minutes. Extraction was carried out by adding 500 ml of chloroform and the organic layer was washed with water after layering. The extraction was repeated once more with 500 ml of chloroform. The organic phases were combined and washed with 10% sodium hydroxide solution and after separating the layers, the chloroform layer was washed with 1500 ml of water. Subsequently, the organic solvent was removed by vacuum distillation. To remove the trace solvent, solvent exchange was performed with 2 x 250 ml of cyclohexane. To the residue, 300 ml of cyclohexane was added, stirred for 3 hours and filtered, and the solid was washed with 200 ml of cyclohexane. Finally, the product was dried in a disk dryer at 65-70 °C for 10-12 hours until the weight loss was less than 1%. The product was obtained as 148 g in 80.95% yield and 86.09% HPLC purity.

References

[1] Asian Journal of Chemistry, 2011, vol. 23, # 4, p. 1655 - 1660
[2] Arzneimittel-Forschung/Drug Research, 2006, vol. 56, # 10, p. 673 - 677
[3] Patent: WO2008/1188, 2008, A2. Location in patent: Page/Page column 8-9
[4] Journal of Medicinal Chemistry, 1998, vol. 41, # 5, p. 658 - 667
[5] Patent: US2006/79689, 2006, A1. Location in patent: Page/Page column 11

3,4-Dihydro-7-(4-bromobutoxy)-2(1H)-quinolinone Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4-Dihydro-7-(4-bromobutoxy)-2(1H)-quinolinone Suppliers

Americas 1 Canada 2 China 230 Europe 3 Germany 3 India 87 Japan 1 South Korea 1 Switzerland 2 United Kingdom 12 United States 33 Global 375

Hangzhou Kaifei Chemical Co.,Ltd.

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Nanjing Chemlin Chemical Co., Ltd

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Chemsky（shanghai）International Co.,Ltd.

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View Lastest Price from 3,4-Dihydro-7-(4-bromobutoxy)-2(1H)-quinolinone manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 3,4-Dihydro-7-(4-bromobutoxy)-2(1H)-quinolinone 129722-34-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

Shaanxi Dideu New Materials Co. Ltd

Product: 3,4-Dihydro-7-(4-bromobutoxy)-2(1H)-quinolinone 129722-34-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-25

Hebei Zhanyao Biotechnology Co. Ltd

Product: 3,4-Dihydro-7-(4-bromobutoxy)-2(1H)-quinolinone 129722-34-5
Price: US $10.00/IU
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-10-14

129722-34-5, 3,4-Dihydro-7-(4-bromobutoxy)-2(1H)-quinolinoneRelated Search:

Isoquinoline Lithium tri-tert-butoxyaluminum hydride Quinolinic acid 1,2,3,4-TETRAHYDROISOQUINOLINE 2-Bromoethylamine hydrobromide Ethoxyquin Quinclorac 1,4-BIS[3,4-DIHYDRO-2(1H)-QUINOLINON-7-OXY]BUTANE 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone Aripiprazole Impurity a Aripiprazole Related CoMpound B 1-(2,3-Dichlorophenyl)piperazine hydrochloride Aripiprazole N1-Oxide 3,4-DIHYDROQUINOLIN-2(1H)-ONE Aripiprazole 1-(4-BROMOBUTOXY)-4-METHYLBENZENE 3,4-Dihydro-7-(4-bromobutoxy)-2(1H)-quinolinone

Aripiprazole Impurity A (Aripip Bromo Impurity)

7-(4-Bromobutoxy)-2-oxo-1,2,3,4-tetrahydroquinoline

3,4-dihydro-7-(4-bromobutoxy)-2(1h)-quinolinone

7-(4-BROMOBUTOXY)-1,2,3,4-TETRAHYDROQUINOLINE-2-ONE

7-(4-BROMO-BUTOXY)-3,4-DIHYDRO-1H-QUINOLIN-2-ONE

7-(4-BROMOBUTOXY)-3,4-DIHYDRO-2(1H)-QUINOLINONE

7-(4-BROMOBUTOXY)-3,4-DIHYDRO-2-QUINOLINONE

(1H)-7-(4'-BROMOBUTOXY)-3,4-DIHYDRO-2-QUINOLINONE

Aripiprazole Bromobutoxyquinoline Impurity

Aripiprazole Impurity i

Aripiprazol Intermediate

7-(4-Bromobutoxy)-2(1h)-3,4-Dihydroquinolinone

7-(4-BROMOBUTOXY)-2(1H)-3,4-DIHYDROQUINOLINONE[INTERMEDIATE FOR ARIPIPRAZOLE]

7-(4-bromobutoxy)-3,4-dihydro-

3,4-DIHYDRO-7-(4-BROMOBUTOXY)-2(1H)-QUINOLINONE/INTERMEDIATE OF ARIPIPRAZOLE

7-(4-Brombutoxy)-3,4-dihydrochinolin-2(1H)-on

3,4-DICHLORO-7(4-BROMOBUTOXY)-2-(1H)-QUINOLINONE

7-(4-BROMOBUTOXY)-3,4-DIHYDRO-2(1H)-QUINOLINONE, 99% ARIPIPRZAOLE INTERMEDIATE

7-(4-BROMOBUTOXY)-3,4-DIHYDRO-1(H)-QUINOLINE -2-ONE

7-(4-bromobuthoxy)-3,4-dihydro-2(1H)quinolinone

7-(4-BROMOBUTOXY)-3,4-DIHYDROQUINOLINE-2(1H)-ONE

7-(4-Bromobutoxy)-1,2,3,4-tetrahydro-2-oxoquinoline

2(1H)-Quinolinone, 7-(4-bromobutoxy)- 3,4-dihydro-

7-hydroxy-(4-BroMobutyloxy)-2(1H)-3,4-dihydroquinolinone

7-(4-broMobutoxy)-3,4-dihydroquinolin-2(1H)-one

7-(4-broMobutoxy)-1,2,3,4-tetrahydroquinolin-2-one

CL041

7-(4-Bromobutoxy)3,4-dihydroquinazolone (BBQ/BBE)

7-(4-Bromobutoxy)-3,4-dihydro-2(1H)-quinolinone &gt

7-(4-Bromobutoxy)-3,4-dihydroquinolin-2(1H)-one(For export only)

3,4-Dihydro-7-(4-bromobutoxy)-2(1H)-quinolinone ISO 9001：2015 REACH

7-(4-BROMOBUTOXY)-3 4-DIHYDROCARBOSTYRYL

Aripiprazole impurities1775

7-(4-Bromobutoxy)-3,4-dihydro-2(1H)-quinolinoneQ: What is 7-(4-Bromobutoxy)-3,4-dihydro-2(1H)-quinolinone Q: What is the CAS Number of 7-(4-Bromobutoxy)-3,4-dihydro-2(1H)-quinolinone Q: What is the storage condition of 7-(4-Bromobutoxy)-3,4-dihydro-2(1H)-quinolinone Q: What are the applications of 7-(4-Bromobutoxy)-3,4-dihydro-2(1H)-quinolinone

TIANFU-CHEM - 3,4-Dihydro-7-(4-bromobutoxy)-2(1H)-quinolinone

Dimer / 7-[4-(3,4 Dihydroquinolin 2(1H) one)oxy]-3,4-dihydroquinolin 2(1H)-one

7- (4-Bromothinyloxy) -3,4-dihydro-2 (1H) - quinolone

7- (4-Bromobutyloxy) -3,4-dihydro-2 (1H) - quinolone

7-(4-Brombutoxy)-3,4-dihydrochinolin-2(1H)-one

Aripiprazole Bromobutoxyquinoline Impurity 7-(4-Bromobutoxy)-3,4-dihydroquinolin-2-one

7-(4-bromobutoxy)-1,2,3,4-tetrahydroquinolin-2-one, >99%

129722-34-5

29722-34-5

C13H16BrNO2

Aripiprazole

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Intermediates of Aripiprazole

Quinoline&Isoquinoline

INTERMEDIATESOFARIPIPRAZOLE