Olaratumab

Product Name: Olaratumab
CAS No.: 1024603-93-7
Chemical Name: Olaratumab
Synonyms: IMC3G3;IMC 3G3;IMC-3G3;Lartruvo;LY3012207;LY-3012207;LY 3012207;Olaratumab;LY3012207|||IMC-3G3;Olaratumab (anti-PDGFRA)
CBNumber: CB84845999
Formula Weight: 0
MOL File: Mol file

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Olaratumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Olaratumab Chemical Properties,Usage,Production

Uses

Olaratumab (IMC-3G3; LY3012207) is an anti-platelet-derived growth factor receptor alpha (PDGFRα) human monoclonal IgG1 antibody with antitumor activity[1].

Clinical Use

Monoclonal antibody:
Treatment of advanced soft tissue sarcoma in combination with doxorubicin

in vivo

IMC-3G3 (i.p., 40 mg/kg, three times per week, 6 weeks) in SKOV3-ip1 tumor-bearing mice, compared with the control group, IMC-3G3 treatment alone had no obvious anti-tumor effect, while in HeyA8 tumor-bearing mice, IMC-3G3 monotherapy showed a significant anti-tumor effect compared with the control group, with a tumor reduction rate of 62%^[1].

Drug interactions

Potentially hazardous interactions with other drugs
Live vaccines: avoid with olaratumab in combination with doxorubicin.

Metabolism

Mainly degraded non-specifically by proteolytic enzymes.

References

[1] Koji Matsuo, et al. Platelet-derived growth factor receptor alpha (PDGFRα) targeting and relevant biomarkers in ovarian carcinoma. Gynecol Oncol. 2014 Jan;132(1):166-75. DOI:10.1016/j.ygyno.2013.10.027

Olaratumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Olaratumab Suppliers

China 20 India 1 Global 21

Wuhan Sunrise Technology Development Co., Ltd.

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Biolab Reagents

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Wuhan Jingkangen Biomedical Technology Co., Ltd

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1024603-93-7, OlaratumabRelated Search:

Bavituximab Atezolizumab Prasinezumab Stamulumab Benralizumab Lumiliximab Fremanezumab Racotumomab Dacliximab Solanezumab

Olaratumab

Research Grade Olaratumab(DHD16101)

IMC 3G3

IMC3G3

IMC-3G3

Lartruvo

LY 3012207

LY3012207

LY-3012207

LY3012207|||IMC-3G3

Research Grade Olaratumab

Olaratumab (anti-PDGFRA)

1024603-93-7