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GANAXOLONE

Product Name
GANAXOLONE
CAS No.
38398-32-2
Chemical Name
GANAXOLONE
Synonyms
Fampridine Impurity 80;5α-PREGNAN-3β-METHYL-3α-;Noradrenaline Impurity 69;5α-PREGNAN-3β-METHYL-3α-OL-20-ONE;3α-hydroxy-3β-methyl-5α-pregnan-20-one;3α-hydroxy-3β-methyl-5α-pregnan-20-one;(3α,5α)-3-Hydroxy-3-methylpregnan-20-one;(3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one;Pregnan-20-one, 3-hydroxy-3-methyl-, (3α,5α)-;1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-Hydroxy-3,10,13-trimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone
CBNumber
CB8498146
Molecular Formula
C22H36O2
Formula Weight
332.52
MOL File
38398-32-2.mol
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GANAXOLONE Property

Melting point:
190-192°
alpha 
D +103°
Boiling point:
434.8±18.0 °C(Predicted)
Density 
1.036±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ~4.2 mg/mL
form 
solid
pka
15.18±0.70(Predicted)
color 
white
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
TU4384700
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G7795
Product name
Ganaxolone
Purity
solid
Packaging
5mg
Price
$196
Updated
2024/03/01
Sigma-Aldrich
Product number
G7795
Product name
Ganaxolone
Purity
solid
Packaging
25mg
Price
$677
Updated
2024/03/01
Cayman Chemical
Product number
20919
Product name
Ganaxolone
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
20919
Product name
Ganaxolone
Purity
≥98%
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
20919
Product name
Ganaxolone
Purity
≥98%
Packaging
10mg
Price
$153
Updated
2024/03/01
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GANAXOLONE Chemical Properties,Usage,Production

Description

Ganaxolone is a 3β-methylated synthetic analog of the neurosteroid allopregnanolone that allosterically enhances GABAA receptor current. At nanomolar concentrations, it can potentiate GABA-evoked currents at GABAA receptor complexes containing α1, α2, α3, β2, and γ2L subunits expressed in Xenopus oocytes. Ganaxolone has been shown to have a broad range of antiseizure activity in animal epilepsy models and human clinical trials.

Uses

Treatment of epilepsy and migraine.

Uses

Ganaxolone, is synthetic neuroactive steroid, which possess sedative, anxiolytic, and anticonvulsant properties. It is also a potent and selective positive allosteric modulator of GABAA receptors. It is also shown to be used for the treatment of epilepsy.

Definition

ChEBI: Ganaxolone is a corticosteroid hormone.

Biological Activity

Potent positive allosteric modulator of GABA A receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABA A receptors (EC 50 values are 94, 122 and 213 nM for α 2 β 1 γ 2 L , α 3 β 1 γ 2 L and α 1 β 1 γ 2 L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.

Biochem/physiol Actions

Ganaxolone (3alpha-hydroxy-3beta-methyl-5alpha-pregnane-20-one) is a positive allosteric modulator of the GABAA receptor subtype; synthetic analog of the endogenous neurosteroid allopregnanolone; effective against chemically induced seizures in rats and mice. Ganaxolone is an orally active analog of allopregnanolone that is not converted to the hormonally active 3-keto form. The enhanced anticonvulsant potency of ganaxolone after neurosteroid withdrawal supports the use of ganaxolone as a specific treatment for perimenstrual catamenial epilepsy.

storage

+4°C

GANAXOLONE Preparation Products And Raw materials

Raw materials

Preparation Products

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GANAXOLONE Suppliers

CHEMICAL LAND21
Tel
--
Fax
--
Email
sales21@chemicalland21.com
Country
South Korea
ProdList
6303
Advantage
74
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View Lastest Price from GANAXOLONE manufacturers

Career Henan Chemical Co
Product
GANAXOLONE 38398-32-2
Price
US $0.01/KG
Min. Order
1KG
Purity
98%; 99%
Supply Ability
500g;1kg; 25kg
Release date
2020-01-09

38398-32-2, GANAXOLONERelated Search:


  • 3α-hydroxy-3β-methyl-5α-pregnan-20-one
  • (3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one
  • 1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-Hydroxy-3,10,13-trimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone
  • (3α,5α)-3-Hydroxy-3-methylpregnan-20-one
  • 1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone
  • Pregnan-20-one, 3-hydroxy-3-methyl-, (3α,5α)-
  • Fampridine Impurity 80
  • 5α-PREGNAN-3β-METHYL-3α-OL-20-ONE
  • 1-[(Chemicalbook3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone
  • 3α-hydroxy-3β-methyl-5α-pregnan-20-one
  • 5α-PREGNAN-3β-METHYL-3α-
  • Noradrenaline Impurity 69
  • 38398-32-2