4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL!MORPHOLINE

Product Name: 4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL!MORPHOLINE
CAS No.: 568577-88-8
Chemical Name: 4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL!MORPHOLINE
Synonyms: 4-(MORPHOLINO)PHENYLBORONIC ACID PINACOLATE;4-MORPHOLINOPHENYLBORONIC ACID, PINACOL ESTER;4-Morpholin-4-ylbenzeneboronic acid pinacol ester;4-(4-Morpholinyl)benzeneboronic acid pinacol ester;4-(4-Morpholinyl)benzeneboronic acid pinacol ester, 95%;4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]morpholine;4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]mor...;4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]MORPHOLINE;4-[4-(4,4,5,5-Tetramethyl-1,2,3-dioxaborolan-2-yl)phenyl]morpholine;Morpholine, 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-
CBNumber: CB8501619
Molecular Formula: C16H24BNO3
Formula Weight: 289.18
MOL File: 568577-88-8.mol

More

Less

4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL!MORPHOLINE Property

Melting point:: 98.6-99.0℃
Boiling point:: 422.8±40.0 °C(Predicted)
Density: 1.09±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: Storage temp. 2-8°C
pka: 4.65±0.40(Predicted)
form: powder to crystal
color: White to Almost white
CAS DataBase Reference: 568577-88-8(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 22-36/37/38
Safety Statements: 26-36/39
WGK Germany: 3
HS Code: 2934999090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS005194
Product name: 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]morpholine
Purity: AldrichCPR
Packaging: 100MG
Price: $73.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: BML00054
Product name: 4-Morpholinophenylboronic acid, pinacol ester
Purity: Aldrich
Packaging: 1g
Price: $107
Updated: 2025/07/31

TCI Chemical

Product number: T3705
Product name: 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]morpholine
Purity: >98.0%(GC)
Packaging: 1g
Price: $123
Updated: 2025/07/31

TCI Chemical

Product number: T3705
Product name: 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]morpholine
Purity: >98.0%(GC)
Packaging: 5g
Price: $489
Updated: 2025/07/31

TRC

Product number: T302773
Product name: 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]morpholine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

More

Less

4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL!MORPHOLINE Chemical Properties,Usage,Production

Uses

4-(4-Morpholinyl)benzeneboronic acid pinacol ester is used as pharmaceutical intermediate.

Synthesis

30483-75-1

25015-63-8

568577-88-8

General procedure for the synthesis of 4-(4-morpholinyl)phenylboronic acid pinacol ester from 4-(4-bromophenyl)morpholine and pinacolborane: To a solution of 4-(4-bromophenyl)morpholine (20 g, 82.64 mmol) in dioxane (200 ml) were added pinacolborane (13.2 g, 99.17 mmol), dichlorobis(triphenylphosphine)palladium(II) (3 g 4.13 mmol) and triethylamine (34.5 ml, 247.93 mmol). The reaction mixture was heated under reflux conditions for 4 hours. After completion of the reaction, the mixture was poured into water. After extraction with dichloromethane, the organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: dichloromethane) to afford 4-(4-morpholinyl)benzeneboronic acid pinacol ester as an orange oil, which crystallized after cooling (19.98 g, 83.94% yield); APCI-MS m/z 289.07 ([M+H]+).

References

[1] Patent: WO2004/13135, 2004, A1. Location in patent: Page 48-49
[2] Patent: WO2004/16606, 2004, A1. Location in patent: Page 25
[3] Patent: WO2004/13138, 2004, A2. Location in patent: Page 23; 24

4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL!MORPHOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL!MORPHOLINE Suppliers

China 104 France 1 Germany 3 India 3 Japan 2 United Kingdom 6 United States 20 Global 139

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Shangchem Co., Ltd.

Tel: +86-21-68182121
Fax: +86-21-68182121
Country: China
ProdList: 882
Advantage: 52

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

skychemical Co.Ltd

Tel: 021-20958197 20965099
Fax: 021-20960837
Email: sales@skychemical.com
Country: China
ProdList: 1183
Advantage: 57

QINGDAO CARELONGPHARMATECH CO.,LTD

Tel: 0532-0532-88191853 13061484198
Fax: +86-532-88191853
Email: sales@carelongchem.com
Country: China
ProdList: 437
Advantage: 57

More

Less

View Lastest Price from 4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL!MORPHOLINE manufacturers

Career Henan Chemical Co

Product: 4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL!MORPHOLINE 568577-88-8
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 804
Release date: 2019-09-02

568577-88-8, 4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL!MORPHOLINERelated Search:

4-(Morpholinomethyl)aniline 4-Morpholinobenzoic acid 4-PYRIMIDINEACETIC ACID 4-MORPHOLINOBENZYLAMINE 4-(MORPHOLINOMETHYL)BENZOIC ACID 4-(PIPERIDIN-4-YL)-MORPHOLINE 4-Morpholinophenylboronic acid 4-(Dimethylamino)phenylboronic acid Pinacol N,N-Diethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL!MORPHOLINE 4-Aminophenylboronic acid pinacol ester 4-(N,N-DIMETHYLAMINO)PHENYLBORONIC ACID, PINACOL ESTER 4-(N-METHYLAMINO)PHENYLBORONIC ACID, PINACOL ESTER

4-Morpholin-4-ylbenzeneboronic acid pinacol ester

4-[4-(4,4,5,5-Tetramethyl-1,2,3-dioxaborolan-2-yl)phenyl]morpholine

Morpholine, 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-

4-(4-Morpholinyl)benzeneboronic acid pinacol ester, 95%

4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]morpholine, 2-[4-(Morpholin-4-yl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]morpholine

4-(MORPHOLINO)PHENYLBORONIC ACID PINACOLATE

4-MORPHOLINOPHENYLBORONIC ACID, PINACOL ESTER

4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]MORPHOLINE

4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]mor...

4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)morpholine - [T24320]

4-(4-Morpholinyl)benzeneboronic acid pinacol ester

568577-88-8

C16H25BNO3

pharmacetical

Boronic Acids & Esters

Phenyls & Phenyl-Het

Boronic Acids & Esters

Phenyls & Phenyl-Het