4-(Morpholinomethyl)aniline

Product Name: 4-(Morpholinomethyl)aniline
CAS No.: 51013-67-3
Chemical Name: 4-(Morpholinomethyl)aniline
Synonyms: AKOS MSC-0181;ASISCHEM U94603;AKOS BBS-00006785;BUTTPARK 98\57-95;TIMTEC-BB SBB010875;CHEMBRDG-BB 4011238;4-(MORPHOLINOMETHYL)ANILINE;4-(4-AMinobenzyl)Morpholine;4-MorpholinoMethylphenylaMine;4-(4-MORPHOLINYLMETHYL)ANILINE
CBNumber: CB8149651
Molecular Formula: C11H16N2O
Formula Weight: 192.26
MOL File: 51013-67-3.mol

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4-(Morpholinomethyl)aniline Property

Melting point:: 95-97°C
Boiling point:: 320.7±27.0 °C(Predicted)
Density: 1.136±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 7.26±0.10(Predicted)
Appearance: White to light yellow Solid
CAS DataBase Reference: 51013-67-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,C
Risk Statements: 20/21/22-34
Safety Statements: 26-36/37/39-45-22
HazardClass: IRRITANT
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: A3736
Product name: 4-(Morpholinomethyl)aniline
Purity: min. 95.0 %
Packaging: 1G
Price: $46
Updated: 2025/07/31

TCI Chemical

Product number: A3736
Product name: 4-(Morpholinomethyl)aniline
Purity: min. 95.0 %
Packaging: 5G
Price: $138
Updated: 2025/07/31

Usbiological

Product number: 282958
Product name: 4-Morpholinomethylaniline
Packaging: 500mg
Price: $468
Updated: 2021/12/16

TRC

Product number: M723770
Product name: 4-Morpholinomethylaniline
Packaging: 10g
Price: $1320
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: COR0002972
Product name: 4-MORPHOLIN-4-YLMETHYLPHENYLAMINE
Purity: 95.00%
Packaging: 10G
Price: $2425.5
Updated: 2021/12/16

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4-(Morpholinomethyl)aniline Chemical Properties,Usage,Production

Uses

4-(Morpholinomethyl)aniline is an aniline derivative used in the preparation of tyrosine kinase inhibitors.

Synthesis

6425-46-3

51013-67-3

General procedure for the synthesis of 4-morpholinomethylaniline from 4-(4-nitrobenzyl)morpholine: 4-(4-nitrobenzyl)morpholine (2.22 g, 10 mmol) was dissolved in methanol under nitrogen atmosphere and 200 mg of Pd/C catalyst was added. Hydrogen was then passed through to carry out the hydrogenation reaction, which lasted for 6 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was collected. The filtrate was concentrated to give 1.83 g of 4-morpholinomethylaniline solid in 95% yield.

References

[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 12, p. 3507 - 3525
[2] RSC Advances, 2015, vol. 5, # 58, p. 47125 - 47130
[3] Patent: CN106432235, 2017, A. Location in patent: Paragraph 0091; 0092
[4] Organic Process Research and Development, 2006, vol. 10, # 3, p. 493 - 499
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 4, p. 1499 - 1518

4-(Morpholinomethyl)aniline Preparation Products And Raw materials

Raw materials

Acetone Potassium carbonate 4-Nitrobenzyl bromide Ammonium chloride Iron Morpholine HEAVY DISTILLATE

Preparation Products

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4-(Morpholinomethyl)aniline Suppliers

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View Lastest Price from 4-(Morpholinomethyl)aniline manufacturers

Career Henan Chemical Co

Product: 4-(Morpholinomethyl)aniline 51013-67-3
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 651
Release date: 2019-09-01

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4-(4-AMinobenzyl)Morpholine

4-(4-MorpholinylMethyl)benzenaMine

4-MorpholinoMethylphenylaMine

BenzenaMine, 4-(4-MorpholinylMethyl)-

4-(morpholin-4-ylmethyl)aniline hydrochloride

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51013-67-3

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