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4-(Morpholinomethyl)aniline

Product Name
4-(Morpholinomethyl)aniline
CAS No.
51013-67-3
Chemical Name
4-(Morpholinomethyl)aniline
Synonyms
AKOS MSC-0181;ASISCHEM U94603;AKOS BBS-00006785;BUTTPARK 98\57-95;TIMTEC-BB SBB010875;CHEMBRDG-BB 4011238;4-(MORPHOLINOMETHYL)ANILINE;4-(4-AMinobenzyl)Morpholine;4-MorpholinoMethylphenylaMine;4-(4-MORPHOLINYLMETHYL)ANILINE
CBNumber
CB8149651
Molecular Formula
C11H16N2O
Formula Weight
192.26
MOL File
51013-67-3.mol
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4-(Morpholinomethyl)aniline Property

Melting point:
95-97°C
Boiling point:
320.7±27.0 °C(Predicted)
Density 
1.136±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
7.26±0.10(Predicted)
Appearance
White to light yellow Solid
CAS DataBase Reference
51013-67-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,C
Risk Statements 
20/21/22-34
Safety Statements 
26-36/37/39-45-22
HazardClass 
IRRITANT
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
A3736
Product name
4-(Morpholinomethyl)aniline
Purity
min. 95.0 %
Packaging
1G
Price
$46
Updated
2025/07/31
TCI Chemical
Product number
A3736
Product name
4-(Morpholinomethyl)aniline
Purity
min. 95.0 %
Packaging
5G
Price
$138
Updated
2025/07/31
Usbiological
Product number
282958
Product name
4-Morpholinomethylaniline
Packaging
500mg
Price
$468
Updated
2021/12/16
TRC
Product number
M723770
Product name
4-Morpholinomethylaniline
Packaging
10g
Price
$1320
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
COR0002972
Product name
4-MORPHOLIN-4-YLMETHYLPHENYLAMINE
Purity
95.00%
Packaging
10G
Price
$2425.5
Updated
2021/12/16
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4-(Morpholinomethyl)aniline Chemical Properties,Usage,Production

Uses

4-(Morpholinomethyl)aniline is an aniline derivative used in the preparation of tyrosine kinase inhibitors.

Synthesis

6425-46-3

51013-67-3

General procedure for the synthesis of 4-morpholinomethylaniline from 4-(4-nitrobenzyl)morpholine: 4-(4-nitrobenzyl)morpholine (2.22 g, 10 mmol) was dissolved in methanol under nitrogen atmosphere and 200 mg of Pd/C catalyst was added. Hydrogen was then passed through to carry out the hydrogenation reaction, which lasted for 6 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was collected. The filtrate was concentrated to give 1.83 g of 4-morpholinomethylaniline solid in 95% yield.

References

[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 12, p. 3507 - 3525
[2] RSC Advances, 2015, vol. 5, # 58, p. 47125 - 47130
[3] Patent: CN106432235, 2017, A. Location in patent: Paragraph 0091; 0092
[4] Organic Process Research and Development, 2006, vol. 10, # 3, p. 493 - 499
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 4, p. 1499 - 1518

4-(Morpholinomethyl)aniline Preparation Products And Raw materials

Raw materials

Acetone Potassium carbonate 4-Nitrobenzyl bromide Ammonium chloride Iron Morpholine HEAVY DISTILLATE

Preparation Products

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4-(Morpholinomethyl)aniline Suppliers

Belgium 1 Canada 1 China 104 Germany 5 India 3 Russia 2 Ukraine 2 United Kingdom 9 United States 23 Global 150
Maybridge Chemical Co., Ltd.
Tel
--
Fax
--
Country
Belgium
ProdList
6293
Advantage
73
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View Lastest Price from 4-(Morpholinomethyl)aniline manufacturers

Career Henan Chemical Co
Product
4-(Morpholinomethyl)aniline 51013-67-3
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
JD 651
Release date
2019-09-01

51013-67-3, 4-(Morpholinomethyl)anilineRelated Search:

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  • BUTTPARK 98\57-95
  • CHEMBRDG-BB 4011238
  • ASISCHEM U94603
  • AKOS MSC-0181
  • AKOS BBS-00006785
  • 4-(MORPHOLINOMETHYL)ANILINE
  • 4-(MORPHOLIN-4-YLMETHYL)ANILINE
  • 4-MORPHOLIN-4-YLMETHYL-PHENYLAMINE
  • 4-(4-MORPHOLINYLMETHYL)ANILINE
  • 4-(morpholinomethyl)benzenamine
  • TIMTEC-BB SBB010875
  • 4-MORPHOLIN-4-YLMETHYLPHENYLAMINE 95%
  • 4-(morpholin-4-ylmethyl)aniline(SALTDATA: FREE)
  • 4-(4-AMinobenzyl)Morpholine
  • 4-(4-MorpholinylMethyl)benzenaMine
  • 4-MorpholinoMethylphenylaMine
  • BenzenaMine, 4-(4-MorpholinylMethyl)-
  • 4-(morpholin-4-ylmethyl)aniline hydrochloride
  • 4-(4-morpholinylmethyl)aniline hydrochloride
  • 51013-67-3
  • Benzene series
  • Amines
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals