2,2',4,4'-TETRABROMODIPHENYL ETHER

Product Name: 2,2',4,4'-TETRABROMODIPHENYL ETHER
CAS No.: 5436-43-1
Chemical Name: 2,2',4,4'-TETRABROMODIPHENYL ETHER
Synonyms: BDE-47;PBDE-47;BDE No 47;NSC 21724;PBDE No. 47;PBDECONGENER47;2,2′,4,4′-TetraBDE;C15898047 PBDENo. 47;BDE No 47 solution;PBDE 47 50 μg/mL in Nonane
CBNumber: CB8506144
Molecular Formula: C12H6Br4O
Formula Weight: 485.79
MOL File: 5436-43-1.mol

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2,2',4,4'-TETRABROMODIPHENYL ETHER Property

Melting point:: 83-84℃ (ethanol )
Boiling point:: 396 °C
Density: 2.161±0.06 g/cm3(Predicted)
Flash point:: -12 °C
storage temp.: Sealed in dry,Room Temperature
solubility: Methanol: Soluble
form: Solid
color: White to off-white
InChI: InChI=1S/C12H6Br4O/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6H
InChIKey: XYBSIYMGXVUVGY-UHFFFAOYSA-N
SMILES: C1(OC2=CC=C(Br)C=C2Br)=CC=C(Br)C=C1Br
EPA Substance Registry System: Benzene, 2,4-dibromo-1-(2,4-dibromophenoxy)- (5436-43-1)

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Safety

Hazard Codes: F,Xn,N
Risk Statements: 11-38-50/53-65-67
Safety Statements: 60-61-62-33-29-16-9
RIDADR: UN 1262 3/PG 2
WGK Germany: 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H304May be fatal if swallowed and enters airways

H315Causes skin irritation

H336May cause drowsiness or dizziness

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P331Do NOT induce vomiting.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 91834
Product name: BDE No 47 solution
Purity: analytical reference material
Packaging: 10mg
Price: $262
Updated: 2025/07/31

Sigma-Aldrich

Product number: 33670
Product name: BDE No 47 solution
Purity: 50μg/mL in isooctane, analytical standard
Packaging: 1ml
Price: $355.6
Updated: 2025/07/31

TRC

Product number: T291145
Product name: 2,4,2'',4''-TetrabromodiphenylEther
Packaging: 2.5g
Price: $1390
Updated: 2021/12/16

TRC

Product number: T291145
Product name: 2,4,2'',4''-TetrabromodiphenylEther
Packaging: 250mg
Price: $180
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 61930
Product name: 2,4,2??,4??-TetrabromodiphenylEther
Packaging: 2.5g
Price: $2200
Updated: 2021/12/16

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2,2',4,4'-TETRABROMODIPHENYL ETHER Chemical Properties,Usage,Production

Uses

2,4,2'',4''-Tetrabromodiphenyl Ether, is one of the Polybrominated di-Ph ethers (PBDEs), which are a new class of global, persistent, and toxic contaminants. It is used as Brominated flame retardants (BFRs) in various consumer products. One of the new POPs under the Stockholm Convention

Definition

ChEBI: 2,2',4,4'-Tetrabromodiphenyl ether is an organobromine compound and an aromatic ether.

Synthesis

615-58-7

5436-43-1

The general procedure for the synthesis of 2,2,4,4-tetrabromodiphenyl ether using 2,4-dibromophenol as starting material: SiO2-ZrO2 (0.05 g) and 2,4-dibromophenol (2.50 g) were placed in a mortar and fully ground for 12 min. After the reaction was completed, n-pentane was used as eluent, and the reaction mixture was separated and purified by silica gel column chromatography, resulting in 2.16 g of white solid product in 89% yield.

References

[1] Patent: CN106957218, 2017, A. Location in patent: Paragraph 0043-0047
[2] AHMED KHALIL. Developmental Exposure to 2,2',4,4'-Tetrabromodiphenyl Ether Permanently Alters Blood-Liver Balance of Lipids in Male Mice.[J]. Frontiers in Endocrinology, 2018: 548. DOI: 10.3389/fendo.2018.00548
[3] XIAOJUAN CHEN. BDE-47 disrupts axonal growth and motor behavior in developing zebrafish[J]. Aquatic Toxicology, 2012, 120: Pages 35-44. DOI: 10.1016/j.aquatox.2012.04.014
[4] CATHRINE THOMSEN*. Changes in Concentrations of Perfluorinated Compounds, Polybrominated Diphenyl Ethers, and Polychlorinated Biphenyls in Norwegian Breast-Milk during Twelve Months of Lactation[J]. Environmental Science and Technology, 2010, 44 24: 9550-9556. DOI: 10.1021/es1021922
[5] CHE-JUNG CHANG . Serum concentrations of polybrominated biphenyls (PBBs), polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in the Michigan PBB Registry 40 years after the PBB contamination incident[J]. Environment International, 2020, 137: Article 105526. DOI: 10.1016/j.envint.2020.105526

2,2',4,4'-TETRABROMODIPHENYL ETHER Preparation Products And Raw materials

Raw materials

Preparation Products

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2,2',4,4'-TETRABROMODIPHENYL ETHER Suppliers

China 83 France 2 India 3 Japan 2 Norway 1 Switzerland 1 United States 8 Global 100

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5436-43-1, 2,2',4,4'-TETRABROMODIPHENYL ETHERRelated Search:

Acid Red 92 Decabromodiphenyl oxide OCTABROMODIPHENYL ETHER 2',4',5',7'-TETRABROMO-3,4,5,6-TETRACHLOROFLUORESCEIN 2,2',4,4'-TETRABROMODIPHENYL ETHER Acid Red 87 4-Bromophenoxybenzene 2,3,4,5-TETRABROMODIPHENYL ETHER 3,4,4',5-TETRACHLOROBIPHENYL 2,4,4',6-TETRABROMODIPHENYL ETHER 2,3',4',6-TETRABROMODIPHENYL ETHER 6-HYDROXY-2,2',4,4'-TETRABROMODIPHENYL ETHER 2,2',4,5'-TETRABROMODIPHENYL ETHER 2,2?3,3?TETRABROMODIPHENYL ETHER EOSIN EOSIN 5-ISOTHIOCYANATE EOSIN DIACETATE THIONINE EOSINATE

BDE No 47

2,2',4,4'-TETRABROMODIPHENYL ETHER

PBDECONGENER47

BDE-47

2,2μ,4,4μ-TetraBDE, 2,2μ,4,4μ-Tetrabromodiphenyl ether solution, PBDE 47

BDE No 47 solution

2,2’,4,4'Tetrabromodiphenyl ether,50ug/ml in Isooctane

1,1'-Oxybis(2,4-dibromobenzene)

2,2',4,4'-Tetrabromo[1,1'-oxybisbenzene]

4,4'-Oxybis(1,3-dibromobenzene)

Bis(2,4-dibromophenyl) ether

2,4-dibromo-1-(2,4-dibromophenoxy)benzene

2,2',4,4'-Tetrabromodiphenyl ether 100mg [5436-43-1]

PBDE-47

2,2',4,4'-Tetrabromodiphenyl oxide

BDE-47(2,2',4,4'-Tetrabromodiphenyl Ether)

NSC 21724

2,2′,4,4′-TetraBDE

2,2',4,4'-Tetrabromodiphenyl ether (BDE 47) Solution

2,2',4,4'-Tetrabromodiphenyl ether (BDE 47)

Benzene, 2,4-dibromo-1-(2,4-dibromophenoxy)-

2,2',4,4'-Tetrabromodiphenylether Solution, 100μg/mL

4，4'-Oxybis(1，3-dibromobenzene),0.97

5436-43-12,2',4,4'-TETRABROMODIPHENYL ETHERC12H6Br4O

PBDE No. 47

PBDB 47 (2,2',4,4',-tetraBROMODIPHENYL ETHER)

2,2’,4,4Tetrabromodiphenyl Ether

C15898047 PBDENo. 47

2,4,2',4'-Tetrabromodiphenyl Ether

PBDE 47 50 μg/mL in Nonane

PBDE No. 47 1000 μg/mL in Methanol

5436-43-1