ChemicalBook > CAS DataBase List > L-838417

L-838417

Product Name
L-838417
CAS No.
286456-42-6
Chemical Name
L-838417
Synonyms
L-838417 ;L-838417_x000b_;5-({[7-tert-butyl-3-(2,5-difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]oxy}methyl)-1-methyl-1,2,4-triazole;7-(tert-Butyl)-3-(2,5-difluorophenyl)-6-((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine;3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4,-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine;1,2,4-Triazolo[4,3-b]pyridazine,3-(2,5-difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-;3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4,-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-β]pyridazine
CBNumber
CB8506755
Molecular Formula
C19H19F2N7O
Formula Weight
399.4
MOL File
286456-42-6.mol
More
Less

L-838417 Property

Melting point:
196-198°C
Density 
1.40±0.1 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
DMSO: ≥20mg/mL
pka
2.13±0.10(Predicted)
form 
powder
color 
white to off-white
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Tocris
Product number
3250
Product name
L-838,417
Purity
≥98%(HPLC)
Packaging
10
Price
$216
Updated
2021/12/16
Tocris
Product number
3250
Product name
L-838,417
Purity
≥98%(HPLC)
Packaging
50
Price
$893
Updated
2021/12/16
TRC
Product number
L838417
Product name
L-838417
Packaging
5mg
Price
$145
Updated
2021/12/16
Usbiological
Product number
281181
Product name
L-838417
Packaging
2mg
Price
$418
Updated
2021/12/16
TRC
Product number
L838417
Product name
L-838417
Packaging
50mg
Price
$740
Updated
2021/12/16
More
Less

L-838417 Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Uses

A selective ligand for GABAA receptors

Uses

L-838417 is an anxiolytic agent and a selective GABAA receptor partial agonist that selectively binds to α1, α2, α3 and α5 subunits (1,2). It also exhibits antinociceptive and anti-inflammatory properties.

Biological Activity

Subtype-selective GABA A receptor partial agonist. Selectively binds to α 1, α 2, α 3 and α 5 subunits (K i values are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy at α 1 ( α 1-sparing). Exhibits non-sedative anxiolytic, antinociceptive and anti-inflammatory activity in vivo .

storage

Store at +4°C

L-838417 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

L-838417 Suppliers

Canada 1 China 36 India 1 United Kingdom 2 United States 10 Global 50
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
ChengDu TongChuangYuan Pharmaceutical Co.Ltd
Tel
028-83379370 13880556291
Fax
028-87747383
Email
tcy@tcypharm.com
Country
China
ProdList
6273
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15084
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52693
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57423
Advantage
58
Shanghai zhigan biotechnology co., LTD
Tel
Email
zhiqianbio@126.com
Country
China
ProdList
19778
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471 +1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58
Advanced chemblocks inc
Tel
650-6922368
Email
sales@achemblock.com
Country
China
ProdList
2992
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Changzhou Furuisi Biotechnology Co., Ltd
Tel
0519-85524369
Email
3477467573@qq.com
Country
China
ProdList
8617
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
Advantage
58
Jiangsu Nanchuang Chemical and Life Health Research Institute Co., Ltd.
Tel
15720605021
Fax
QQ：353175721
Email
zhang_lei@jsnchem.com
Country
China
ProdList
1645
Advantage
58
JinOu Biomedical (Nanjing) Co., Ltd.
Tel
13000000000
Fax
jinoupharma@163
Email
jinoupharma@163.com
Country
China
ProdList
11721
Advantage
58
Shanghai Universal Biotech Co.,Ltd
Tel
13774214275
Email
zhouzz@univ-bio.com
Country
China
ProdList
24995
Advantage
58
Jiaxing Zhejia Biotechnology Co., LTD
Tel
0573-85609002
Email
zhejia01@163.com
Country
China
ProdList
8875
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58
PharmaBlock Sciences (Nanjing), Inc.
Tel
4000255188 4000255188
Email
sales@pharmablock.com
Country
China
ProdList
7268
Advantage
58
Auonsi (Shanghai) Biology Technology Co., Ltd.
Tel
400-1107768 15058188853
Fax
0571-88150696
Email
478133536@qq.com
Country
China
ProdList
8552
Advantage
58
Shandong Mingde Biotechnology Co., Ltd
Tel
15553348166
Email
m15553348166@163.com
Country
China
ProdList
9647
Advantage
58
SHANGHAI KEAN TECHNOLOGY CO., LTD.
Tel
+8613817748580
Fax
021-50175322
Email
cooperation@kean-chem.com
Country
China
ProdList
40066
Advantage
58
Suzhou ARTK Medchem Co., Ltd.
Tel
+86-512-68323658 +86-18168183658
Email
sales1@artkmedchem.com
Country
China
ProdList
39004
Advantage
58
Shanghai Acmec Biochemical Technology Co., Ltd.
Tel
+undefined18621343501
Email
product@acmec-e.com
Country
China
ProdList
33338
Advantage
58
Shanghai Yuda Industrial Co., Ltd.
Tel
--
Fax
--
Email
lucy@runwelltac.com
Country
CHINA
ProdList
6105
Advantage
58
Shanghai Jingke Chemical Technology Co., Ltd.
Tel
--
Fax
--
Email
jingkehuaxue@163.com
Country
CHINA
ProdList
6972
Advantage
58
Shanghai Yubo Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
344843571@qq.com
Country
CHINA
ProdList
6318
Advantage
58
Shanghai Caiyou Industrial Co., Ltd.
Tel
--
Fax
--
Email
15821073967@163.com
Country
CHINA
ProdList
6893
Advantage
58
Beijing Luyuan Bird Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
15810802415@139.com
Country
CHINA
ProdList
6750
Advantage
58
Shanghai Qincheng Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shqcsw01@163.com
Country
CHINA
ProdList
6367
Advantage
58
Shanghai Ziqi Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
2453006496@qq.com
Country
CHINA
ProdList
6184
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Debye Scientific Corporation
Tel
--
Fax
--
Country
China
ProdList
6891
Advantage
50

286456-42-6, L-838417 Related Search:

Phenylphosphonic dichloride N,N'-Diphenylurea 2-FLUOROPHENYL CYCLOPENTYL KETONE TRIS(PENTAFLUOROPHENYL)PHOSPHINE TRIS(PENTAFLUOROPHENYL)BORANE (2-METHYL-2H-[1,2,4]TRIAZOL-3-YL)-METHANOL L-838417

  • 3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4,-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-β]pyridazine
  • 7-(tert-Butyl)-3-(2,5-difluorophenyl)-6-((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine
  • 1,2,4-Triazolo[4,3-b]pyridazine,3-(2,5-difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-
  • L-838417
  • 3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4,-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine
  • 5-({[7-tert-butyl-3-(2,5-difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]oxy}methyl)-1-methyl-1,2,4-triazole
  • L-838417_x000b_
  • 286456-42-6
  • C19H19F2N7O
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Heterocyclic Compounds
  • Pharmaceuticals