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L-838417

Product Name
L-838417
CAS No.
286456-42-6
Chemical Name
L-838417
Synonyms
L-838417 ;L-838417_x000b_;5-({[7-tert-butyl-3-(2,5-difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]oxy}methyl)-1-methyl-1,2,4-triazole;7-(tert-Butyl)-3-(2,5-difluorophenyl)-6-((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine;3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4,-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine;1,2,4-Triazolo[4,3-b]pyridazine,3-(2,5-difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-;3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4,-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-β]pyridazine
CBNumber
CB8506755
Molecular Formula
C19H19F2N7O
Formula Weight
399.4
MOL File
286456-42-6.mol
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L-838417 Property

Melting point:
196-198°C
Density 
1.40±0.1 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
DMSO: ≥20mg/mL
pka
2.13±0.10(Predicted)
form 
powder
color 
white to off-white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
3250
Product name
L-838,417
Purity
≥98%(HPLC)
Packaging
10
Price
$216
Updated
2021/12/16
Tocris
Product number
3250
Product name
L-838,417
Purity
≥98%(HPLC)
Packaging
50
Price
$893
Updated
2021/12/16
TRC
Product number
L838417
Product name
L-838417
Packaging
5mg
Price
$145
Updated
2021/12/16
Usbiological
Product number
281181
Product name
L-838417
Packaging
2mg
Price
$418
Updated
2021/12/16
TRC
Product number
L838417
Product name
L-838417
Packaging
50mg
Price
$740
Updated
2021/12/16
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L-838417 Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Uses

A selective ligand for GABAA receptors

Uses

L-838417 is an anxiolytic agent and a selective GABAA receptor partial agonist that selectively binds to α1, α2, α3 and α5 subunits (1,2). It also exhibits antinociceptive and anti-inflammatory properties.

Biological Activity

Subtype-selective GABA A receptor partial agonist. Selectively binds to α 1, α 2, α 3 and α 5 subunits (K i values are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy at α 1 ( α 1-sparing). Exhibits non-sedative anxiolytic, antinociceptive and anti-inflammatory activity in vivo .

storage

Store at +4°C

L-838417 Preparation Products And Raw materials

Raw materials

Preparation Products

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L-838417 Suppliers

Canada 1 China 36 India 1 United Kingdom 2 United States 10 Global 50

286456-42-6, L-838417 Related Search:

Phenylphosphonic dichloride N,N'-Diphenylurea 2-FLUOROPHENYL CYCLOPENTYL KETONE TRIS(PENTAFLUOROPHENYL)PHOSPHINE TRIS(PENTAFLUOROPHENYL)BORANE (2-METHYL-2H-[1,2,4]TRIAZOL-3-YL)-METHANOL L-838417

  • 3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4,-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-β]pyridazine
  • 7-(tert-Butyl)-3-(2,5-difluorophenyl)-6-((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine
  • 1,2,4-Triazolo[4,3-b]pyridazine,3-(2,5-difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-
  • L-838417
  • 3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4,-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine
  • 5-({[7-tert-butyl-3-(2,5-difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]oxy}methyl)-1-methyl-1,2,4-triazole
  • L-838417_x000b_
  • 286456-42-6
  • C19H19F2N7O
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Heterocyclic Compounds
  • Pharmaceuticals