3-AMINOPHENYL N,N-DIMETHYLCARBAMATE, 97
- Product Name
- 3-AMINOPHENYL N,N-DIMETHYLCARBAMATE, 97
- CAS No.
- 19962-04-0
- Chemical Name
- 3-AMINOPHENYL N,N-DIMETHYLCARBAMATE, 97
- Synonyms
- Neostigmine bromide Impurity L;Neostigmine bromide Impurity 4;3-Aminophenyl dimethylcarbamate;3-aminophenyl N,N-dimethylcarbamate;Cyclobutanecarboxylicacid,3,5-difluoro-;3-AMINOPHENYL N,N-DIMETHYLCARBAMATE, 97;N,N-Dimethylcarbamic acid 3-aminophenyl ester;Carbamic acid, N,N-dimethyl-, 3-aminophenyl ester
- CBNumber
- CB8506775
- Molecular Formula
- C9H12N2O2
- Formula Weight
- 180.2
- MOL File
- 19962-04-0.mol
3-AMINOPHENYL N,N-DIMETHYLCARBAMATE, 97 Property
- Melting point:
- 85-88 °C
- Boiling point:
- 198-202 °C(Press: 9 Torr)
- Density
- 1.176±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 3.69±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 2429CA
- Product name
- 3-Aminophenyldimethylcarbamate
- Packaging
- 100mg
- Price
- $153
- Updated
- 2021/12/16
- Product number
- CHM0023310
- Product name
- 3-AMINOPHENYL N,N-DIMETHYLCARBAMATE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $598.97
- Updated
- 2021/12/16
- Product number
- CHM0023310
- Product name
- 3-AMINOPHENYL N,N-DIMETHYLCARBAMATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $733.96
- Updated
- 2021/12/16
- Product number
- A119757
- Product name
- 3-Aminophenyldimethylcarbamate
- Purity
- 97%
- Packaging
- 5g
- Price
- $784
- Updated
- 2021/12/16
- Product number
- 61-3026
- Product name
- 3-Aminophenyldimethylcarbamate
- Purity
- 95%-98%
- Packaging
- 0.25g
- Price
- $882
- Updated
- 2021/12/16
3-AMINOPHENYL N,N-DIMETHYLCARBAMATE, 97 Chemical Properties,Usage,Production
Synthesis
7244-70-4
591-27-5
19962-04-0
GENERAL STEPS: To a dry 500 mL four-necked round-bottomed flask were added dimethyl sulfoxide (DMSO, 100 mL), 3-aminophenol (67.5 g) and sodium hydroxide (NaOH, 24.7 g). The reaction mixture was heated to 75-80 °C and maintained at this temperature for 4 hours. Subsequently, 4-nitrophenyl-N,N-dimethylcarbamate (100 g) and DMSO (100 mL) were added in batches at the same temperature. The reaction temperature was raised to 110-120 °C and the reaction was continued for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction was quenched with 1% sodium hydroxide solution (1500 mL). Extraction was carried out with methylene chloride (MDC), the organic layer was separated, washed with water, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was recrystallized with toluene to obtain pure 3-aminophenyl dimethylcarbamate. Yield: 62 g (72.2% yield). Melting point: 83-85°C (literature value: 80-86°C, FR 1498834).
References
[1] Patent: WO2017/175238, 2017, A1. Location in patent: Page/Page column 31
3-AMINOPHENYL N,N-DIMETHYLCARBAMATE, 97 Preparation Products And Raw materials
Raw materials
Preparation Products
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