ChemicalBook > CAS DataBase List > 6-Chloroindole-3-carboxaldehyde

6-Chloroindole-3-carboxaldehyde

Product Name
6-Chloroindole-3-carboxaldehyde
CAS No.
703-82-2
Chemical Name
6-Chloroindole-3-carboxaldehyde
Synonyms
6-Chloro-3-formylindole;6-Chloro-3-formyl-1H-indole;6-Chloro Indole-3-Carbaldehyde;6-fluoroindole-3-carboxaldhyde;6-Chloro-3-Indolecarboxaldehyde;6-Chloroindole-3-carboxaldehyde;6-chloroindole-3-carboxaladehyde;6-Chloro-1H-indole-3-carboxaldehyde;6-CHLOROINDOLE-3-CARBOXALDEHYDE 98%;1H-Indole-3-carboxaldehyde,6-chloro-
CBNumber
CB8512321
Molecular Formula
C9H6ClNO
Formula Weight
179.6
MOL File
703-82-2.mol
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6-Chloroindole-3-carboxaldehyde Property

Melting point:
2-3 °C
Boiling point:
373.4±22.0 °C(Predicted)
Density 
1.431±0.06 g/cm3(Predicted)
storage temp. 
2-8°C, stored under nitrogen
pka
14.60±0.30(Predicted)
form 
Powder
color 
Pale brown
Water Solubility 
Slightly soluble in water
CAS DataBase Reference
703-82-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
B418673
Product name
6-Chloro-1H-indole-3-carbaldehyde
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
B418673
Product name
6-Chloro-1H-indole-3-carbaldehyde
Packaging
500mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC147095
Product name
6-Chloroindole-3-carboxaldehyde
Packaging
10g
Price
$396
Updated
2021/12/16
Matrix Scientific
Product number
089676
Product name
6-Chloroindole-3-carboxaldehyde
Packaging
25g
Price
$434
Updated
2021/12/16
AK Scientific
Product number
V0120
Product name
6-Chloroindole-3-carboxaldehyde
Packaging
100g
Price
$534
Updated
2021/12/16
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6-Chloroindole-3-carboxaldehyde Chemical Properties,Usage,Production

Uses

6-Chloroindole-3-carboxaldehyde can react with dimethyldisulfane to get 6-chloro-(3-thiomethyl)-indole.

Synthesis

17422-33-2

68-12-2

703-82-2

GENERAL STEPS: Oxalyl chloride (0.3 mL) was slowly added dropwise to ice-bath cooled N,N-dimethylformamide (DMF, 3 mL) under stirring conditions. The reaction mixture was stirred continuously at 0 °C for 1 hour. Subsequently, a solution of 6-chloroindole (4 mmol) dissolved in DMF (1.5 mL) was added slowly dropwise to the above reaction mixture. The resulting mixture was stirred and reacted at room temperature for 5 hours. Upon completion of the reaction, 2 N sodium hydroxide solution (2 mL) was added and the mixture was heated to 100°C maintained for 10 minutes. The reaction solution was cooled and extracted with ethyl acetate (3 x 50 mL). The organic phases were combined and washed sequentially with water and saturated saline. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain the crude product. The crude product was purified by fast column chromatography with the eluent of ethyl acetate/petroleum ether (3:1, v/v) to give pure 6-chloroindole-3-carbaldehyde.

References

[1] Journal of the American Chemical Society, 2006, vol. 128, # 6, p. 1995 - 2004
[2] European Journal of Medicinal Chemistry, 2013, vol. 65, p. 158 - 167
[3] Patent: WO2015/42053, 2015, A1. Location in patent: Paragraph 00331
[4] Patent: WO2016/144704, 2016, A2. Location in patent: Paragraph 00370
[5] Chemical and Pharmaceutical Bulletin, 2016, vol. 64, # 1, p. 34 - 41

6-Chloroindole-3-carboxaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-Chloroindole-3-carboxaldehyde manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
6-Chloro-1H-indole-3-carbaldehyde 703-82-2
Price
US $1.60-6.60/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-19
Chemwill Asia Co.,Ltd.
Product
6-Chloroindole-3-carboxaldehyde in stock Factory 703-82-2
Price
US $1.00/KG
Min. Order
1KG
Purity
TOP 3 Factory in China
Supply Ability
Top 3 largest production capacity Factory
Release date
2019-04-03
Career Henan Chemical Co
Product
6-Chloroindole-3-carboxaldehyde 703-82-2
Price
US $1.00/g
Min. Order
100g
Purity
99%
Supply Ability
G/KG/T
Release date
2019-12-20

703-82-2, 6-Chloroindole-3-carboxaldehydeRelated Search:

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