6-Chloroindole-3-carboxaldehyde
- Product Name
- 6-Chloroindole-3-carboxaldehyde
- CAS No.
- 703-82-2
- Chemical Name
- 6-Chloroindole-3-carboxaldehyde
- Synonyms
- 6-Chloro-3-formylindole;6-Chloro-3-formyl-1H-indole;6-Chloro Indole-3-Carbaldehyde;6-fluoroindole-3-carboxaldhyde;6-Chloro-3-Indolecarboxaldehyde;6-Chloroindole-3-carboxaldehyde;6-chloroindole-3-carboxaladehyde;6-Chloro-1H-indole-3-carboxaldehyde;6-CHLOROINDOLE-3-CARBOXALDEHYDE 98%;1H-Indole-3-carboxaldehyde,6-chloro-
- CBNumber
- CB8512321
- Molecular Formula
- C9H6ClNO
- Formula Weight
- 179.6
- MOL File
- 703-82-2.mol
6-Chloroindole-3-carboxaldehyde Property
- Melting point:
- 2-3 °C
- Boiling point:
- 373.4±22.0 °C(Predicted)
- Density
- 1.431±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, stored under nitrogen
- pka
- 14.60±0.30(Predicted)
- form
- Powder
- color
- Pale brown
- Water Solubility
- Slightly soluble in water
- CAS DataBase Reference
- 703-82-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B418673
- Product name
- 6-Chloro-1H-indole-3-carbaldehyde
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B418673
- Product name
- 6-Chloro-1H-indole-3-carbaldehyde
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC147095
- Product name
- 6-Chloroindole-3-carboxaldehyde
- Packaging
- 10g
- Price
- $396
- Updated
- 2021/12/16
- Product number
- 089676
- Product name
- 6-Chloroindole-3-carboxaldehyde
- Packaging
- 25g
- Price
- $434
- Updated
- 2021/12/16
- Product number
- V0120
- Product name
- 6-Chloroindole-3-carboxaldehyde
- Packaging
- 100g
- Price
- $534
- Updated
- 2021/12/16
6-Chloroindole-3-carboxaldehyde Chemical Properties,Usage,Production
Uses
6-Chloroindole-3-carboxaldehyde can react with dimethyldisulfane to get 6-chloro-(3-thiomethyl)-indole.
Synthesis
17422-33-2
68-12-2
703-82-2
GENERAL STEPS: Oxalyl chloride (0.3 mL) was slowly added dropwise to ice-bath cooled N,N-dimethylformamide (DMF, 3 mL) under stirring conditions. The reaction mixture was stirred continuously at 0 °C for 1 hour. Subsequently, a solution of 6-chloroindole (4 mmol) dissolved in DMF (1.5 mL) was added slowly dropwise to the above reaction mixture. The resulting mixture was stirred and reacted at room temperature for 5 hours. Upon completion of the reaction, 2 N sodium hydroxide solution (2 mL) was added and the mixture was heated to 100°C maintained for 10 minutes. The reaction solution was cooled and extracted with ethyl acetate (3 x 50 mL). The organic phases were combined and washed sequentially with water and saturated saline. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain the crude product. The crude product was purified by fast column chromatography with the eluent of ethyl acetate/petroleum ether (3:1, v/v) to give pure 6-chloroindole-3-carbaldehyde.
References
[1] Journal of the American Chemical Society, 2006, vol. 128, # 6, p. 1995 - 2004
[2] European Journal of Medicinal Chemistry, 2013, vol. 65, p. 158 - 167
[3] Patent: WO2015/42053, 2015, A1. Location in patent: Paragraph 00331
[4] Patent: WO2016/144704, 2016, A2. Location in patent: Paragraph 00370
[5] Chemical and Pharmaceutical Bulletin, 2016, vol. 64, # 1, p. 34 - 41
6-Chloroindole-3-carboxaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
6-Chloroindole-3-carboxaldehyde Suppliers
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View Lastest Price from 6-Chloroindole-3-carboxaldehyde manufacturers
- Product
- 6-Chloro-1H-indole-3-carbaldehyde 703-82-2
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- 6-Chloroindole-3-carboxaldehyde in stock Factory 703-82-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- TOP 3 Factory in China
- Supply Ability
- Top 3 largest production capacity Factory
- Release date
- 2019-04-03
- Product
- 6-Chloroindole-3-carboxaldehyde 703-82-2
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 99%
- Supply Ability
- G/KG/T
- Release date
- 2019-12-20