giredestrant

Product Name: giredestrant
CAS No.: 1953133-47-5
Chemical Name: giredestrant
Synonyms: RG6171;RG 6171;RG-6171;GDC-9545;giredestrant;Giredestrant,GDC-0945;GDC-9545(Giredestrant);Giredestrant(GDC-9545）;Giredestrant, 10 mM in DMSO;ligand,conformational,GDC 9545,inhibit,non-steroidal,anti-tumor,GDC9545,Inhibitor,Giredestrant,orally,Estrogen Receptor/ERR,change
CBNumber: CB85839636
Molecular Formula: C27H31F5N4O
Formula Weight: 522.55
MOL File: 1953133-47-5.mol

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giredestrant Property

Boiling point:: 618.8±55.0 °C(Predicted)
Density: 1.333±0.06 g/cm3(Predicted)
pka: 13.68±0.10(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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giredestrant Chemical Properties,Usage,Production

Uses

Giredestrant (GDC-9545), a non-steroidal estrogen receptor (ER) ligand, is an orally active and selective ER antagonist. Giredestrant potently competes with Estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity[1].

IC 50

ER

References

[1] C Metcalfe, et al. Abstract P5-04-07: GDC-9545: A novel ER antagonist and clinical candidate that combines desirable mechanistic and pre-clinical DMPK attributes

giredestrant Preparation Products And Raw materials

Raw materials

Preparation Products

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giredestrant Suppliers

China 49 United States 2 Global 51

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

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1953133-47-5, giredestrantRelated Search:

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GDC-9545(Giredestrant)

RG 6171

RG6171

RG-6171

Giredestrant,GDC-0945

Giredestrant(GDC-9545）

ligand,conformational,GDC 9545,inhibit,non-steroidal,anti-tumor,GDC9545,Inhibitor,Giredestrant,orally,Estrogen Receptor/ERR,change

3-((1R,3R)-1-(2,6-Difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol

Giredestrant, 10 mM in DMSO

1953133-47-5

C27H31F5N4O

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