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Calcipotriol Monohydrate

Product Name
Calcipotriol Monohydrate
CAS No.
147657-22-5
Chemical Name
Calcipotriol Monohydrate
Synonyms
Calcipotriol monohydrate CRS;Calcipotriol m;Carbotriol monohydrate;CALCIPOTRIOL MONOHYDRATE;Calcipotriol monohydrate 98%;Calcipotriol monohydrate - Bio-X ?;Calcipotriol monohydrate, 10 mM in DMSO;Calcipotriol (Calcipotriene) Monohydrate;(5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1α,3β,24-triol;(1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol hydrate
CBNumber
CB8588339
Molecular Formula
C27H42O4
Formula Weight
430.63
MOL File
147657-22-5.mol
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Calcipotriol Monohydrate Property

storage temp. 
4°C, protect from light, stored under nitrogen,unstable in solution, ready to use.
solubility 
Practically insoluble in water, freely soluble in ethanol (96 per cent), slightly soluble in methylene chloride.
form 
Powder
color 
White to off-white
Stability:
Hygroscopic, Light sensitive
InChIKey
XBKHACNRWFKJNC-IZXATKCONA-N
SMILES
C[C@]12CCC/C(=C\C=C3\C[C@@H](O)C[C@H](O)C\3=C)/[C@]1([H])CC[C@]2([H])[C@H](C)/C=C/[C@H](C1CC1)O.O |&1:1,10,13,17,21,23,27,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H310Fatal in contact with skin

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P350IF ON SKIN: Gently wash with plenty of soap and water.

P310Immediately call a POISON CENTER or doctor/physician.

P322Specific measures (see …on this label).

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10009599
Product name
Calcipotriol (hydrate)
Packaging
10mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
10009599
Product name
Calcipotriol (hydrate)
Packaging
500mg
Price
$2505
Updated
2024/03/01
Cayman Chemical
Product number
10009599
Product name
Calcipotriol (hydrate)
Packaging
50mg
Price
$324
Updated
2024/03/01
Cayman Chemical
Product number
10009599
Product name
Calcipotriol (hydrate)
Packaging
100mg
Price
$575
Updated
2024/03/01
TRC
Product number
C144230
Product name
CalcipotriolMonohydrate
Packaging
25mg
Price
$825
Updated
2021/12/16
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Calcipotriol Monohydrate Chemical Properties,Usage,Production

Description

Calcipotriol (hydrate) is a low-calcemic vitamin D receptor (VDR) agonist. Calcipotriol (hydrate) is about 200 times less potent in its effects on calcium metabolism than vitamin D (1,25[OH]D3). Binding of calcipotriol (hydrate) to the VDR increases AP-1, a transcription factor important for keratinocyte differentiation, and reduces expression of JunB protein, a transcriptional activator in the inflammatory response. Calcipotriol (hydrate) also induces expression of thymic stromal lymphopoietin, which triggers T-cell differentiation in keratinocytes.

Chemical Properties

White or almost white, crystalline powder.

Uses

Calcipotriol monohydrate is a synthetic vitamin D3 analog with high affinity for the vitamin D receptor. It is used alone or in combination with betamethasone dipropionate for the treatment of psoriasis.

Definition

ChEBI: Calcipotriol hydrate is a hydrate that is the monohydrate form of calcipotriol. It is used in combination with betamethasone dipropionate, a corticosteroid, for the topical treatment of plaque psoriasis in adult patients. It has a role as an antipsoriatic. It contains a calcipotriol.

in vivo

One out of the 32 animals in each of the groups has died, except for the Diclofenac plus DFMO plus Calcipotriol group, where all animals survived. Survival is equally distributed between the groups. The weight gain is significantly smaller in the groups treated with Diclofenac plus Calcipotriol (p=0.018) and Diclofenac plus DFMO plus Calcipotriol (p=0.002) compare with placebo (linear regression model)[3].

References

[1] KRAGBALLE K. Vitamin D analogues in the treatment of psoriasis[J]. Journal of cellular biochemistry, 1992, 49 1: 46-52. DOI: 10.1002/jcb.240490109
[2] C. JOHANSEN. Activator protein 1 DNA binding activity is decreased in lesional psoriatic skin compared with nonlesional psoriatic skin[J]. British Journal of Dermatology, 2004, 151 3: 600-607. DOI: 10.1111/j.1365-2133.2004.06088.x
[3] MEI LI. Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis.[J]. ACS Catalysis , 2006: 11736-11741. DOI: 10.1073/pnas.0604575103

Calcipotriol Monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Calcipotriol Monohydrate Suppliers

China 149 Denmark 1 France 1 India 10 Israel 1 Switzerland 1 United Kingdom 1 United States 12 Global 176
Jiangxi ravel Biotechnology Co.,Ltd
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400-880-2824 15608648206
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1987516016@qq.com
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China
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Chembest Research Laboratories Limited
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+86-21-20908456
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021-58180499
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sales@BioChemBest.com
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Nanjing Chemlin Chemical Co., Ltd
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025-83697070
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+86-25-83453306
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Wuhan Sunrise Technology Development Co., Ltd.
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27-027-83314682 13554138826
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+86 (27) 8331-4682
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whsrtech@vip.163.com
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BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
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United States
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Wuhan Fortuna Chemical Co., Ltd
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QQ3130921841
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buy@fortunachem.com
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Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
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sales@meilune.com
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China
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Haoyuan Chemexpress Co., Ltd.
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021-58950125
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(86) 21-58955996
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info@chemexpress.com
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China
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Nanjing Sunlida Biological Technology Co., Ltd.
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025-57798810
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025-57019371
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sales@sunlidabio.com
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China
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AdooQ BioScience, LLC
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+1 (866) 930-6790
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+1 (866) 333-9607
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United States
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View Lastest Price from Calcipotriol Monohydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Calcipotriol Monohydrate 147657-22-5
Price
US $0.00-0.00/g
Min. Order
1g
Purity
97.5%
Supply Ability
50g
Release date
2025-11-19
HangZhou RunYan Pharma Technology Co.,LTD.
Product
Calcipotriol Monohydrate 147657-22-5
Price
US $0.00-0.00/g
Min. Order
10g
Purity
95.5%
Supply Ability
10000
Release date
2024-11-08
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Calcipotriol 147657-22-5
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-11-15

147657-22-5, Calcipotriol MonohydrateRelated Search:

(2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-Bis[[(tert-butyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-cyclopropyl-2-penten-1-one Carboplatin CALCIUM THIOGLYCOLATE TRIHYDRATE Calcipotriene Calcipotriene

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