ChemicalBook > CAS DataBase List > 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE

4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE

Product Name
4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE
CAS No.
749886-87-1
Chemical Name
4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE
Synonyms
JSH-23;CS-1344;JSH-23 HCL;JSH-23;JSH23;JSH 23;NF-κB Activation Inhibitor II;NFκB Activation Inhibitor II, JSH-23;4-Methyl-N1-(3-phenylpropyl)-1,2-benzenediamine;4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE;4-methyl-1-N-(3-phenylpropyl)benzene-1,2-diamine;4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine
CBNumber
CB8649474
Molecular Formula
C16H20N2
Formula Weight
240.34
MOL File
Mol file
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4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE Property

Melting point:
104.4-105.0℃
Boiling point:
418.7±40.0 °C(Predicted)
Density 
1.086±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: >10mg/mL
pka
5.99±0.11(Predicted)
form 
solid
color 
off-white to gray-pink
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-41-50/53
Safety Statements 
26-39-60-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
HS Code 
2921.59.8090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
J4455
Product name
JSH-23
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$176
Updated
2024/03/01
TCI Chemical
Product number
M2734
Product name
4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine
Purity
>98.0%(GC)
Packaging
25mg
Price
$212
Updated
2022/04/27
TCI Chemical
Product number
M2734
Product name
4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine
Purity
>98.0%(GC)
Packaging
100mg
Price
$464
Updated
2024/03/01
Cayman Chemical
Product number
15036
Product name
JSH-23
Purity
≥98%
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
15036
Product name
JSH-23
Purity
≥98%
Packaging
5mg
Price
$120
Updated
2024/03/01
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4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE Chemical Properties,Usage,Production

Uses

A cell-permeable, selective blocker of nuclear translocation of NF-KB p65. NF-KB activation inhibitor II, JSH-23

Uses

JSH-23 is a cell-permeable, selective blocker of nuclear translocation of NF-KB p65. NF-KB activation inhibitor II.

Uses

JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.

Definition

ChEBI: JSH-23 is a diamine that is 1,2-phenylenediamine carrying a methyl substituent at position 4 and a 3-phenylpropyl substituent at position N1. It has a role as a NF-kappaB inhibitor. It is a diamine and a substituted aniline. It is functionally related to a 1,2-phenylenediamine.

General Description

A cell-permeable diamino compound that selectively blocks nuclear translocation of NF-κB p65 and its transcription activity (IC50 = 7.1 μM in a NF-κB reporter assay using RAW 264.7) without affecting IκB degradation. Shown to suppress DNA-binding of NF-κB and downregulate LPS-induced gene expression and apoptotic chromatin condensation.

Biological Activity

jsh-23 is an inhibitor of nf-κb transcriptional activity with ic50 value of 7.1μm [1].jsh-23 is developed to inhibit nf-κb transcriptional activity in lps-stimulated macrophages raw 264.7. it shows a dose-dependent inhibition. this effect is not due to its cytotoxicity. in the same condition, jsh-23 is found to significantly decrease the lps-induced dna binding activity of nf-κb while decrease nuclear amount of nf-κb p65. jsh-23 plays these roles without affecting iκb degradation. in addition, jsh-23 also shows inhibition effects on the expression of the pro-inflammatory transcripts and enzymes, including il-6, il-1β, cox-2 and tnf-α. furthermore, jsh-23 inhibits lps-induced apoptotic chromatin condensation [1].

Biochem/physiol Actions

Primary TargetBlocks nuclear translocation of NF-κB p65 and its transcription activity

target

NF-κB

References

[1] shin hm, kim mh, kim bh, jung sh, kim ys, park hj, hong jt, min kr, kim y. inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of nf-kappab without affecting ikappab degradation. febs lett. 2004 jul 30;571(1-3):50-4.

4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE Suppliers

Shanghai Boyle Chemical Co., Ltd.
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86-21-57758967
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sales@boylechem.com
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China
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
Email
jkinfo@jkchemical.com
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China
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Chembest Research Laboratories Limited
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021-58180499
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TCI (Shanghai) Development Co., Ltd.
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021-67121386
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021-67121385
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Sales-CN@TCIchemicals.com
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China
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VDM Biochemicals
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United States
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Dalian Meilun Biotech Co., Ltd.
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ShangHai YuanYe Biotechnology Co., Ltd.
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Haoyuan Chemexpress Co., Ltd.
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TOKYO CHEMICAL INDUSTRY CO., LTD.
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03-3668-0520
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Japan
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View Lastest Price from 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE manufacturers

Career Henan Chemical Co
Product
4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE 749886-87-1
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-12

749886-87-1, 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINERelated Search:


  • 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE
  • JSH-23
  • 4-Methyl-N1-(3-phenylpropyl)-1,2-benzenediamine
  • 4-Methyl-N1-(3-phenylpropyl)-1,2-benzenediamine JSH 23
  • JSH-23;JSH23;JSH 23;NF-ΚB ACTIVATION INHIBITOR II
  • NF-κB Activation Inhibitor II
  • JSH 23 4-Methyl-N1-(3-phenylpropyl)-1,2-benzenediamine
  • 4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine
  • 4-methyl-1-N-(3-phenylpropyl)benzene-1,2-diamine
  • NFκB Activation Inhibitor II, JSH-23
  • JSH-23;JSH23;JSH 23
  • CS-1344
  • NF-κB Activation Inhibitor II, JSH-23 - CAS 749886-87-1 - Calbiochem
  • 4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine&gt
  • 1,2-Benzenediamine, 4-methyl-N1-(3-phenylpropyl)-
  • 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE USP/EP/BP
  • JSH-23 HCL
  • Nuclear factor-κB,Nuclear factor-kappaB,JSH-23,NF-κB,JSH23,JSH 23,Inhibitor,inhibit
  • JSH-23, 98%, an NF-κB inhibitor which inhibits NF-κB transcriptional activity
  • 749886-87-1
  • Chemical Amines
  • Amines
  • Aromatics
  • Inhibitors