4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE
- Product Name
- 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE
- CAS No.
- 749886-87-1
- Chemical Name
- 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE
- Synonyms
- JSH-23;CS-1344;JSH-23 HCL;JSH-23;JSH23;JSH 23;NF-κB Activation Inhibitor II;NFκB Activation Inhibitor II, JSH-23;4-Methyl-N1-(3-phenylpropyl)-1,2-benzenediamine;4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE;4-methyl-1-N-(3-phenylpropyl)benzene-1,2-diamine;4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine
- CBNumber
- CB8649474
- Molecular Formula
- C16H20N2
- Formula Weight
- 240.34
- MOL File
- Mol file
4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE Property
- Melting point:
- 104.4-105.0℃
- Boiling point:
- 418.7±40.0 °C(Predicted)
- Density
- 1.086±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: >10mg/mL
- pka
- 5.99±0.11(Predicted)
- form
- solid
- color
- off-white to gray-pink
Safety
- Hazard Codes
- Xn,N
- Risk Statements
- 22-41-50/53
- Safety Statements
- 26-39-60-61
- RIDADR
- UN 3077 9 / PGIII
- WGK Germany
- 3
- HS Code
- 2921.59.8090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
H400Very toxic to aquatic life
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- J4455
- Product name
- JSH-23
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $176
- Updated
- 2024/03/01
- Product number
- M2734
- Product name
- 4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine
- Purity
- >98.0%(GC)
- Packaging
- 25mg
- Price
- $212
- Updated
- 2022/04/27
- Product number
- M2734
- Product name
- 4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine
- Purity
- >98.0%(GC)
- Packaging
- 100mg
- Price
- $464
- Updated
- 2024/03/01
- Product number
- 15036
- Product name
- JSH-23
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 15036
- Product name
- JSH-23
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2024/03/01
4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE Chemical Properties,Usage,Production
Uses
A cell-permeable, selective blocker of nuclear translocation of NF-KB p65. NF-KB activation inhibitor II, JSH-23
Uses
JSH-23 is a cell-permeable, selective blocker of nuclear translocation of NF-KB p65. NF-KB activation inhibitor II.
Uses
JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.
Definition
ChEBI: JSH-23 is a diamine that is 1,2-phenylenediamine carrying a methyl substituent at position 4 and a 3-phenylpropyl substituent at position N1. It has a role as a NF-kappaB inhibitor. It is a diamine and a substituted aniline. It is functionally related to a 1,2-phenylenediamine.
General Description
A cell-permeable diamino compound that selectively blocks nuclear translocation of NF-κB p65 and its transcription activity (IC50 = 7.1 μM in a NF-κB reporter assay using RAW 264.7) without affecting IκB degradation. Shown to suppress DNA-binding of NF-κB and downregulate LPS-induced gene expression and apoptotic chromatin condensation.
Biological Activity
jsh-23 is an inhibitor of nf-κb transcriptional activity with ic50 value of 7.1μm [1].jsh-23 is developed to inhibit nf-κb transcriptional activity in lps-stimulated macrophages raw 264.7. it shows a dose-dependent inhibition. this effect is not due to its cytotoxicity. in the same condition, jsh-23 is found to significantly decrease the lps-induced dna binding activity of nf-κb while decrease nuclear amount of nf-κb p65. jsh-23 plays these roles without affecting iκb degradation. in addition, jsh-23 also shows inhibition effects on the expression of the pro-inflammatory transcripts and enzymes, including il-6, il-1β, cox-2 and tnf-α. furthermore, jsh-23 inhibits lps-induced apoptotic chromatin condensation [1].
Biochem/physiol Actions
Primary TargetBlocks nuclear translocation of NF-κB p65 and its transcription activity
target
NF-κB
References
[1] shin hm, kim mh, kim bh, jung sh, kim ys, park hj, hong jt, min kr, kim y. inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of nf-kappab without affecting ikappab degradation. febs lett. 2004 jul 30;571(1-3):50-4.
4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE manufacturers
- Product
- 4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE 749886-87-1
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-12