ChemicalBook > CAS DataBase List > 2,4-DIFLUORO-5-NITROBENZONITRILE

2,4-DIFLUORO-5-NITROBENZONITRILE

Product Name: 2,4-DIFLUORO-5-NITROBENZONITRILE
CAS No.: 67152-20-9
Chemical Name: 2,4-DIFLUORO-5-NITROBENZONITRILE
Synonyms: 2,4-Difluoro-5-ntirobenzonitrile;5-Cyano-2,4-difluoronitrobenzene;2,4-DIFLUORO-5-NITROBENZONITRILE;2,4-difluoro-5-nitrobenzene nitrile;Benzonitrile, 2,4-difluoro-5-nitro-
CBNumber: CB8665841
Molecular Formula: C7H2F2N2O2
Formula Weight: 184.1
MOL File: 67152-20-9.mol

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2,4-DIFLUORO-5-NITROBENZONITRILE Property

Boiling point:: 271.5±40.0 °C(Predicted)
Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
Appearance: Off-white to light yellow Solid

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D446210
Product name: 2,4-Difluoro-5-nitrobenzonitrile
Packaging: 1g
Price: $120
Updated: 2021/12/16

Usbiological

Product number: 159918
Product name: 2,4-Difluoro-5-nitrobenzonitrile
Packaging: 1g
Price: $403
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0002147
Product name: 2,4-DIFLUORO-5-NITROBENZONITRILE
Purity: 95.00%
Packaging: 5G
Price: $814.28
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0002147
Product name: 2,4-DIFLUORO-5-NITROBENZONITRILE
Purity: 95.00%
Packaging: 25G
Price: $1299.38
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD32867
Product name: 2,4-Difluoro-5-nitrobenzonitrile
Packaging: 25g
Price: $262.5
Updated: 2021/12/16

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2,4-DIFLUORO-5-NITROBENZONITRILE Chemical Properties,Usage,Production

Chemical Properties

white powder

Uses

2,4-Difluoro-5-nitrobenzonitrile is used in the synthesis of potent and selective tankyrase inhbitors used in the inhibition of tumorigenesis.

Synthesis

3939-09-1

67152-20-9

General procedure for the synthesis of 2,4-difluoro-5-nitrobenzonitrile from 2,4-difluorobenzonitrile: Potassium nitrate (16.4 g, 147.4 mmol) was slowly added to concentrated sulfuric acid (85 ml, 1582 mmol) at 0 °C, followed by 2,4-difluorobenzonitrile (11.0 g, 79.1 mmol) dropwise. The reaction mixture was stirred at this temperature for 4 hours. Upon completion of the reaction, the mixture was quenched by pouring into ice/water (800 mL). The precipitated solid product was collected by filtration and dried to give 2,4-difluoro-5-nitrobenzonitrile (13.8 g, 95% yield) as a white solid. The product was confirmed by NMR hydrogen spectrum (400 MHz, CDCl3): δ 8.48 (m, 1H), 7.24 (m, 1H).

References

[1] Patent: WO2006/87530, 2006, A1. Location in patent: Page/Page column 59
[2] Patent: WO2005/103010, 2005, A2. Location in patent: Page/Page column 40
[3] Patent: CN106854165, 2017, A. Location in patent: Paragraph 0106; 0107; 0138; 0139
[4] Journal of Medicinal Chemistry, 1994, vol. 37, # 4, p. 467 - 475
[5] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 15, p. 2019 - 2022

2,4-DIFLUORO-5-NITROBENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,4-DIFLUORO-5-NITROBENZONITRILE manufacturers

Career Henan Chemical Co

Product: 2,4-DIFLUORO-5-NITROBENZONITRILE 67152-20-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-25

67152-20-9, 2,4-DIFLUORO-5-NITROBENZONITRILERelated Search:

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2,4-DIFLUORO-5-NITROBENZONITRILE

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2,4-Difluoro-5-ntirobenzonitrile

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2,4-difluoro-5-nitrobenzene nitrile

67152-20-9

Aromatic Nitriles