2,4-DIFLUORO-5-NITROBENZONITRILE
- Product Name
- 2,4-DIFLUORO-5-NITROBENZONITRILE
- CAS No.
- 67152-20-9
- Chemical Name
- 2,4-DIFLUORO-5-NITROBENZONITRILE
- Synonyms
- 2,4-Difluoro-5-ntirobenzonitrile;5-Cyano-2,4-difluoronitrobenzene;2,4-DIFLUORO-5-NITROBENZONITRILE;2,4-difluoro-5-nitrobenzene nitrile;Benzonitrile, 2,4-difluoro-5-nitro-
- CBNumber
- CB8665841
- Molecular Formula
- C7H2F2N2O2
- Formula Weight
- 184.1
- MOL File
- 67152-20-9.mol
2,4-DIFLUORO-5-NITROBENZONITRILE Property
- Boiling point:
- 271.5±40.0 °C(Predicted)
- Density
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Off-white to light yellow Solid
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D446210
- Product name
- 2,4-Difluoro-5-nitrobenzonitrile
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 159918
- Product name
- 2,4-Difluoro-5-nitrobenzonitrile
- Packaging
- 1g
- Price
- $403
- Updated
- 2021/12/16
- Product number
- HCH0002147
- Product name
- 2,4-DIFLUORO-5-NITROBENZONITRILE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $814.28
- Updated
- 2021/12/16
- Product number
- HCH0002147
- Product name
- 2,4-DIFLUORO-5-NITROBENZONITRILE
- Purity
- 95.00%
- Packaging
- 25G
- Price
- $1299.38
- Updated
- 2021/12/16
- Product number
- FD32867
- Product name
- 2,4-Difluoro-5-nitrobenzonitrile
- Packaging
- 25g
- Price
- $262.5
- Updated
- 2021/12/16
2,4-DIFLUORO-5-NITROBENZONITRILE Chemical Properties,Usage,Production
Chemical Properties
white powder
Uses
2,4-Difluoro-5-nitrobenzonitrile is used in the synthesis of potent and selective tankyrase inhbitors used in the inhibition of tumorigenesis.
Synthesis
3939-09-1
67152-20-9
General procedure for the synthesis of 2,4-difluoro-5-nitrobenzonitrile from 2,4-difluorobenzonitrile: Potassium nitrate (16.4 g, 147.4 mmol) was slowly added to concentrated sulfuric acid (85 ml, 1582 mmol) at 0 °C, followed by 2,4-difluorobenzonitrile (11.0 g, 79.1 mmol) dropwise. The reaction mixture was stirred at this temperature for 4 hours. Upon completion of the reaction, the mixture was quenched by pouring into ice/water (800 mL). The precipitated solid product was collected by filtration and dried to give 2,4-difluoro-5-nitrobenzonitrile (13.8 g, 95% yield) as a white solid. The product was confirmed by NMR hydrogen spectrum (400 MHz, CDCl3): δ 8.48 (m, 1H), 7.24 (m, 1H).
References
[1] Patent: WO2006/87530, 2006, A1. Location in patent: Page/Page column 59
[2] Patent: WO2005/103010, 2005, A2. Location in patent: Page/Page column 40
[3] Patent: CN106854165, 2017, A. Location in patent: Paragraph 0106; 0107; 0138; 0139
[4] Journal of Medicinal Chemistry, 1994, vol. 37, # 4, p. 467 - 475
[5] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 15, p. 2019 - 2022
2,4-DIFLUORO-5-NITROBENZONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
2,4-DIFLUORO-5-NITROBENZONITRILE Suppliers
- Tel
- --
- Fax
- --
- export@ecochem.dk
- Country
- Europe
- ProdList
- 6371
- Advantage
- 66
- Tel
- --
- Fax
- --
- Sales@kemikalieimport.dk
- Country
- Europe
- ProdList
- 6685
- Advantage
- 47
View Lastest Price from 2,4-DIFLUORO-5-NITROBENZONITRILE manufacturers
- Product
- 2,4-DIFLUORO-5-NITROBENZONITRILE 67152-20-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-25