3-Fluoro-4-aminobenzonitrile

Product Name: 3-Fluoro-4-aminobenzonitrile
CAS No.: 63069-50-1
Chemical Name: 3-Fluoro-4-aminobenzonitrile
Synonyms: 4-AMINO-3-FLUOROBENZONITRILE;BUTTPARK 144\07-21;3-Fluoro-4-aminobenz;4-CYANO-2-FLUOROANILINE;3-FLUORO-4-AMINOBENZONITRILE;4-Amino-3-fluorobenzonitrile98%;Benzonitrile, 4-amino-3-fluoro-;4-Amino-3-fluorobenzonitrile >4-Amino-3-fluorobenzonitrile,99%;4-Amino-3-fluorobenzonitrile 98%
CBNumber: CB1405624
Molecular Formula: C7H5FN2
Formula Weight: 136.13
MOL File: 63069-50-1.mol

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3-Fluoro-4-aminobenzonitrile Property

Melting point:: 70-74
Boiling point:: 264.2±25.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 0.33±0.10(Predicted)
color: White to Light yellow to Light orange
InChIKey: RLMBRRQWBTWGMB-UHFFFAOYSA-N
CAS DataBase Reference: 63069-50-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T
Risk Statements: 20/21/22-36/38
Safety Statements: 26-36/37
RIDADR: UN3439
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29269090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H311Toxic in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: A1965
Product name: 4-Amino-3-fluorobenzonitrile
Purity: >98.0%(GC)
Packaging: 5g
Price: $156
Updated: 2025/07/31

TCI Chemical

Product number: A1965
Product name: 4-Amino-3-fluorobenzonitrile
Purity: >98.0%(GC)
Packaging: 25g
Price: $621
Updated: 2025/07/31

TRC

Product number: A898185
Product name: 4-Amino-3-fluorobenzonitrile
Packaging: 10g
Price: $85
Updated: 2021/12/16

Matrix Scientific

Product number: 021130
Product name: 4-Amino-3-fluorobenzonitrile
Purity: 98%
Packaging: 5g
Price: $10
Updated: 2021/12/16

AK Scientific

Product number: J90448
Product name: 4-Amino-3-fluorobenzonitrile
Packaging: 5g
Price: $10
Updated: 2021/12/16

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3-Fluoro-4-aminobenzonitrile Chemical Properties,Usage,Production

Chemical Properties

Off-white to brown crystalline

Uses

4-Amino-3-fluorobenzonitrile is used in preparation of substituted 1,6-Naphthyridine inhibitors of CDK5.

Synthesis

29632-74-4

544-92-3

63069-50-1

Step 1: Synthesis of 4-amino-3-fluorobenzonitrile 2-Fluoro-4-iodoaniline (2.0 g, 8.4 mmol) and cuprous cyanide (982 mg, 11.0 mmol, 1.5 eq.) were added to N,N-dimethylformamide (DMF, 30 mL). The reaction mixture was heated to 130 °C and the reaction was stirred at this temperature for 8 hours. After completion of the reaction, the mixture was cooled to room temperature and diluted with ethyl acetate. The diluted solution was washed sequentially with deionized water (2 times) and saturated saline, and then dried with anhydrous magnesium sulfate. The dried solution was concentrated by filtration and the crude product obtained was purified by column chromatography (eluent: n-hexane/ethyl acetate = 3:1, v/v) to give the white solid product 4-amino-3-fluorobenzonitrile (914 mg, 84% yield). 1H NMR (300 MHz, CDCl3): δ 7.21-7.26 (m, 2H), 6.74 (t, 1H, J = 8.3 Hz), 4.20 (bs, 2H).

References

[1] Patent: WO2007/120012, 2007, A1. Location in patent: Page/Page column 82-83; 129
[2] Patent: WO2006/63113, 2006, A2. Location in patent: Page/Page column 68-69

3-Fluoro-4-aminobenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Fluoro-4-aminobenzonitrile Suppliers

Americas 1 Belgium 1 China 197 Europe 3 Germany 1 India 7 Italy 1 Japan 3 South Korea 1 United Kingdom 18 United States 33 Global 266

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Wuhan Chemwish Technology Co., Ltd

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Capot Chemical Co., Ltd

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View Lastest Price from 3-Fluoro-4-aminobenzonitrile manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-Fluoro-4-aminobenzonitrile 63069-50-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-04

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Fluoro-4-aminobenzonitrile 63069-50-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Fluoro-4-aminobenzonitrile 63069-50-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

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BUTTPARK 144\07-21

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63069-50-1

63009-50-1

Amines

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FluoroCompounds

Aromatic Nitriles

Fluorobenzonitrile Series