ChemicalBook > CAS DataBase List > 3-Fluoro-4-aminobenzonitrile

3-Fluoro-4-aminobenzonitrile

Product Name
3-Fluoro-4-aminobenzonitrile
CAS No.
63069-50-1
Chemical Name
3-Fluoro-4-aminobenzonitrile
Synonyms
4-AMINO-3-FLUOROBENZONITRILE;BUTTPARK 144\07-21;3-Fluoro-4-aminobenz;4-CYANO-2-FLUOROANILINE;3-FLUORO-4-AMINOBENZONITRILE;4-Amino-3-fluorobenzonitrile98%;Benzonitrile, 4-amino-3-fluoro-;4-Amino-3-fluorobenzonitrile >4-Amino-3-fluorobenzonitrile,99%;4-Amino-3-fluorobenzonitrile 98%
CBNumber
CB1405624
Molecular Formula
C7H5FN2
Formula Weight
136.13
MOL File
63069-50-1.mol
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3-Fluoro-4-aminobenzonitrile Property

Melting point:
70-74
Boiling point:
264.2±25.0 °C(Predicted)
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
0.33±0.10(Predicted)
color 
White to Light yellow to Light orange
InChIKey
RLMBRRQWBTWGMB-UHFFFAOYSA-N
CAS DataBase Reference
63069-50-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,T
Risk Statements 
20/21/22-36/38
Safety Statements 
26-36/37
RIDADR 
UN3439
Hazard Note 
Irritant
HazardClass 
6.1
PackingGroup 
III
HS Code 
29269090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H311Toxic in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
A1965
Product name
4-Amino-3-fluorobenzonitrile
Purity
>98.0%(GC)
Packaging
5g
Price
$156
Updated
2025/07/31
TCI Chemical
Product number
A1965
Product name
4-Amino-3-fluorobenzonitrile
Purity
>98.0%(GC)
Packaging
25g
Price
$621
Updated
2025/07/31
TRC
Product number
A898185
Product name
4-Amino-3-fluorobenzonitrile
Packaging
10g
Price
$85
Updated
2021/12/16
Matrix Scientific
Product number
021130
Product name
4-Amino-3-fluorobenzonitrile
Purity
98%
Packaging
5g
Price
$10
Updated
2021/12/16
AK Scientific
Product number
J90448
Product name
4-Amino-3-fluorobenzonitrile
Packaging
5g
Price
$10
Updated
2021/12/16
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3-Fluoro-4-aminobenzonitrile Chemical Properties,Usage,Production

Chemical Properties

Off-white to brown crystalline

Uses

4-Amino-3-fluorobenzonitrile is used in preparation of substituted 1,6-Naphthyridine inhibitors of CDK5.

Synthesis

29632-74-4

544-92-3

63069-50-1

Step 1: Synthesis of 4-amino-3-fluorobenzonitrile 2-Fluoro-4-iodoaniline (2.0 g, 8.4 mmol) and cuprous cyanide (982 mg, 11.0 mmol, 1.5 eq.) were added to N,N-dimethylformamide (DMF, 30 mL). The reaction mixture was heated to 130 °C and the reaction was stirred at this temperature for 8 hours. After completion of the reaction, the mixture was cooled to room temperature and diluted with ethyl acetate. The diluted solution was washed sequentially with deionized water (2 times) and saturated saline, and then dried with anhydrous magnesium sulfate. The dried solution was concentrated by filtration and the crude product obtained was purified by column chromatography (eluent: n-hexane/ethyl acetate = 3:1, v/v) to give the white solid product 4-amino-3-fluorobenzonitrile (914 mg, 84% yield). 1H NMR (300 MHz, CDCl3): δ 7.21-7.26 (m, 2H), 6.74 (t, 1H, J = 8.3 Hz), 4.20 (bs, 2H).

References

[1] Patent: WO2007/120012, 2007, A1. Location in patent: Page/Page column 82-83; 129
[2] Patent: WO2006/63113, 2006, A2. Location in patent: Page/Page column 68-69

3-Fluoro-4-aminobenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Fluoro-4-aminobenzonitrile Suppliers

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View Lastest Price from 3-Fluoro-4-aminobenzonitrile manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
3-Fluoro-4-aminobenzonitrile 63069-50-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-12-04
Zhuozhou Wenxi import and Export Co., Ltd
Product
3-Fluoro-4-aminobenzonitrile 63069-50-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
3-Fluoro-4-aminobenzonitrile 63069-50-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

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