Antazoline

Product Name: Antazoline
CAS No.: 91-75-8
Chemical Name: Antazoline
Synonyms: 5512-M;Avissul;Azalone;Antastan;Antasten;Antistin;Antazolin;Antistine;Chemiopen;Histostab
CBNumber: CB8667315
Molecular Formula: C17H19N3
Formula Weight: 265.35
MOL File: 91-75-8.mol

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Antazoline Property

Melting point:: 120-122°
Boiling point:: 398.57°C (rough estimate)
Density: 0.9786 (rough estimate)
refractive index: 1.6080 (estimate)
pka: pKa 6.65(H2O t = 25 I = 0.05) (Uncertain)
form: A solid
color: White to off-white
Water Solubility: 663.4mg/L(30 ºC)
CAS DataBase Reference: 91-75-8(CAS DataBase Reference)
NIST Chemistry Reference: Antazoline(91-75-8)

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Safety

Hazardous Substances Data: 91-75-8(Hazardous Substances Data)
Toxicity: LD50 oral in mouse: 398mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FA30098
Product name: Antazoline
Packaging: 100mg
Price: $70
Updated: 2021/12/16

AK Scientific

Product number: G399
Product name: Antazoline
Packaging: 100mg
Price: $98
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA30098
Product name: Antazoline
Packaging: 250mg
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA30098
Product name: Antazoline
Packaging: 500mg
Price: $160
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007303
Product name: ANTAZOLINE
Purity: 95.00%
Packaging: 100MG
Price: $225.75
Updated: 2021/12/16

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Antazoline Chemical Properties,Usage,Production

Chemical Properties

White, odorless crystalline powder with bitter taste. Sparingly soluble in alcohol and water; practically insoluble in benzene and ether.

Originator

Antistine HCl,Ciba,US,1948

Uses

Antihistaminic.

Definition

ChEBI: A member of the class of imidazolines that is 2-aminomethyl-2-imidazoline in which the exocyclic amino hydrogens are replaced by benzyl and phenyl groups. Antazoline is only found in individuals that have taken the drug.

Manufacturing Process

15.4 parts of 2-chloromethylimidazoline hydrochloride, 45.8 parts of Nbenzylaniline and 150 parts of alcohol are heated in an oil bath at 100° to 110°C. After distilling off the alcohol, the reaction mass is maintained at this temperature for a further 3 hours and then triturated with water and 10 parts of sodium bicarbonate. The unconsumed benzylaniline is extracted with ether and the aqueous solution neutralized with dilute hydrochloric acid. By evaporating this solution and extracting the residue with alcohol there is obtained 2-(N-phenyl-N-benzylaminomethyl)imidazoline hydrochloride in the form of colorless crystals of melting point 227° to 229°C.

Therapeutic Function

Antihistaminic

Clinical Use

Antazoline is used for local application to the eye in allergic conjunctivitis.

Safety Profile

Poison by ingestion, subcutaneous, and intraperitoneal routes. An eye irritant. When heated to decomposition it emits toxic fumes of NOx.

Antazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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Antazoline Suppliers

China 46 Europe 1 Germany 1 India 4 South Korea 1 United Kingdom 3 United States 23 Global 79

LGM Pharma

Tel: 1-(800)-881-8210
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Creative Peptides

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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
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ProdList: 32165
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Aladdin Scientific

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TargetMol Chemicals Inc.

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Alfa Chemistry

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United States Biological

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Alchem Pharmtech, Inc.

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HBCChem, Inc.

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American Custom Chemicals Corporation

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OChem Incorporation

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HBCChem Inc.

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Chem-Impex International, Inc.

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Waterstone Technology, LLC

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HONEST JOY HOLDINGS LIMITED

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2A PharmaChem USA

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3B Scientific Corporation

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ASDI Incorporated

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MP Biomedicals, Inc.

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AK Scientific, Inc.

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BOSCHE SCIENTIFIC, LLC

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View Lastest Price from Antazoline manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Antazoline 91-75-8
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-05-11

Hebei Ganmiao New material Technology Co., LTD

Product: Antazoline 91-75-8
Price: US $13.00-7.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 200ton
Release date: 2024-06-19

Hebei Mojin Biotechnology Co.,Ltd

Product: Antazoline 91-75-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2024-07-22

91-75-8, AntazolineRelated Search:

Dimethylbenzylcarbinyl acetate Quinazoline Oxazoline Benzyl acetate 3,3',5,5'-Tetramethylbenzidine dihydrochloride Benzyl chloromethyl ether Aniline Benzyldimethylcarbinyl butyrate Benzyltrimethylammonium hydroxide Dihydromyrcenol N-Methylaniline Benzoyl peroxide N,N-Dimethylaniline 1-Methylimidazole Benzyl chloride Benzyl alcohol Benzyl benzoate ANTAZOLINE HCL,ANTAZOLINE HYDROCHLORIDE

1H-Imidazole-2-methanamine, 4,5-dihydro-N-phenyl-N-(phenylmethyl)-

2-(N-Phenyl-N-benzylaminomethyl)imidazoline

2-[(N-Benzylanilino)methyl]-2-imidazol

2-[(N-Benzylanilino)methyl]-2-imidazoline

2-Imidazoline, 2-[(N-benzylanilino)methyl]-

2-Phenyl-benzyl-amino-methylimidazolin

4,5-Dihydro-N-phenyl-N-phenylmethyl-1H-imidazole-2-methanamine

5512-M

Allergan A

Analergine

Antastan

Antasten

Antazolin

Antihistal

Antistin

Antistine

Archisulfa

Avissul

Azalone

Ben-a-hist

n-benzyl-n-(4,5-dihydro-1h-imidazol-2-ylmethyl)aniline

Chemiopen

Demosulfan

Histostab

Imidamine

Orosulfan

Phenazoline

Risulfasens

Sulfaperine

Sulfatreis

albalon-a

2-(N-PHENYL-N-BENZYL-AMINOMETHYL)-IMIDAZOLINE 0.5 H2SO4

BENZYL-(4,5-DIHYDRO-1H-IMIDAZOL-2-YLMETHYL)-PHENYL-AMINE 0.5 H2SO4

ANTAZOLINE

ANTAZOLINE 0.5 H2SO4

N-benzyl-N-(2-imidazolin-2-ylmethyl)aniline

Antazoline (base and/or unspecified salts)

N-benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)benzenamine

Antazoline & Antazoline Hydrochloride

Antazoline Hydrochloride Ph. Eur.

Antazoline USP/EP/BP

nervous system,Inhibitor,H1 receptor antagonist,inhibit,Phenazoline,Antazoline,Histamine Receptor

91-75-8

C17H20N3Cl

Imidazoline agonist; more potent than efaroxan in inducing insulin release from beta cells; H1 histamine receptor antagonist.