Climbazole
Risks to the environment- Product Name
- Climbazole
- CAS No.
- 38083-17-9
- Chemical Name
- Climbazole
- Synonyms
- CLIMBAZOL;baypival;Crinipan AD;1-[(4-Chlorophenoxy)(tert-butylcarbonyl)Methyl]iMidazole;1-(4-Chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one;BAYSAN;MEB-6401;climbazo;bay-e6975;Diadimefon
- CBNumber
- CB8671477
- Molecular Formula
- C15H17ClN2O2
- Formula Weight
- 292.76
- MOL File
- 38083-17-9.mol
Climbazole Property
- Melting point:
- 96-100°C
- Boiling point:
- 447.5±40.0 °C(Predicted)
- Density
- 1.17±0.1 g/cm3(Predicted)
- vapor pressure
- 0.001Pa at 25℃
- refractive index
- 1.54
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Insoluble in water
- form
- Solid
- pka
- 5.66±0.22(Predicted)
- color
- White to Almost white
- Water Solubility
- 58mg/L at 25℃
- BRN
- 618020
- InChIKey
- OWEGWHBOCFMBLP-UHFFFAOYSA-N
- LogP
- 3.83 at 25℃
- CAS DataBase Reference
- 38083-17-9(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- 36127
- Product name
- Climbazole
- Purity
- PESTANAL?, analytical standard
- Packaging
- 100mg
- Price
- $108
- Updated
- 2025/07/31
- Product number
- 1135600
- Product name
- Climbazole
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 400mg
- Price
- $376
- Updated
- 2025/07/31
- Product number
- C2025
- Product name
- Climbazole
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $60
- Updated
- 2025/07/31
- Product number
- C2025
- Product name
- Climbazole
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 500g
- Price
- $483
- Updated
- 2025/07/31
- Product number
- 27968
- Product name
- (±)-Climbazole
- Packaging
- 50g
- Price
- $78
- Updated
- 2024/03/01
Climbazole Chemical Properties,Usage,Production
Risks to the environment
Climbazole (CBZ) is an emerging recalcitrant contaminant in wastewater, which has severe toxic effects on aquatic organisms.
Description
(±)-Climbazole is an imidazole antifungal agent. It inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = <0.06-1 μg/ml) and M. furfur (MICs = <0.06-0.5 μg/ml) in vitro. It also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo. (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver. Formulations containing climbazole have been used in the treatment of dandruff.
Chemical Properties
White Solid
Uses
Climbazole is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix. s assay and did not induce micronuclei in human lymphocytes.
Definition
ChEBI: 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one is a ketone that is butan-2-one substituted by a 4-chlorophenoxy and a 1H-imidazol-1-yl group at position 1 and 2 methyl groups at position 3. It is a member of monochlorobenzenes, a member of imidazoles, an aromatic ether, a ketone and a hemiaminal ether.
Hazard
Moderately toxic by ingestion. Low toxicity by skin contact.
Flammability and Explosibility
Non flammable
Side effects
May cause localized irritation of the skin with symptoms including redness, rashes and itching.
References
[1] P. CAVANA . Efficacy of a 2% climbazole shampoo for reducing Malassezia population sizes on the skin of naturally infected dogs[J]. Journal de mycologie medicale, 2015, 25 4: Pages 268-273. DOI: 10.1016/j.mycmed.2015.10.004
[2] MARIOS STYLIANOU. Antifungal application of nonantifungal drugs.[J]. Antimicrobial Agents and Chemotherapy, 2014, 58 2: 1055-1062. DOI: 10.1128/aac.01087-13
[3] SCHMIDT D A. In vitro Activity of Climbazole, Clotrimazole and Silver-sulphadiazine against Isolates of Malassezia pachydermatis[J]. Zoonoses and Public Health, 2010, 44 1-10: 193-197. DOI: 10.1111/j.1439-0450.1997.tb00964.x
[4] A SCHMIDT B R H. In vitro susceptibility of Malassezia furfur against azole compounds.[J]. Mycoses, 1996, 39 7-8: 309-312. DOI: 10.1111/j.1439-0507.1996.tb00145.x
[5] KOBAYASHI Y, SUZUKI M, OHSHIRO N, et al. Climbazole is a new potent inducer of rat hepatic cytochrome P450.[J]. The Journal of toxicological sciences, 2001, 62 1: 0. DOI: 10.2131/jts.26.141
Climbazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Climbazole manufacturers
- Product
- Climbazole 38083-17-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-11-20
- Product
- Climbazole 38083-17-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 20tons
- Release date
- 2025-08-26
- Product
- CLIMBAZOLE 38083-17-9
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2024-08-23