ChemicalBook > CAS DataBase List > Creatinine

Creatinine

Product Name
Creatinine
CAS No.
60-27-5
Chemical Name
Creatinine
Synonyms
Diisopropylamine dichloroacetate;DADA;CREATININ;1-METHYLHYDANTOIN-2-IMIDE;2-IMINO-1-METHYLIMIDAZOLIDIN-4-ONE;Cubisol;b-Anoxin;KREATININ;NSC 13123;CREATININE
CBNumber
CB8672212
Molecular Formula
C4H7N3O
Formula Weight
113.12
MOL File
60-27-5.mol
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Creatinine Property

Melting point:
295 °C (dec.) (lit.)
Boiling point:
211.83°C (rough estimate)
Density 
1.2526 (rough estimate)
refractive index 
1.5700 (estimate)
Flash point:
290 °C
storage temp. 
Sealed in dry,Room Temperature
solubility 
1 M HCl: 0.1 g/mL at 20 °C, clear
pka
4.83(at 25℃)
form 
Crystalline Powder
color 
White
PH Range
7.5 - 8.5
Water Solubility 
SOLUBLE
Merck 
14,2569
BRN 
112061
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
DDRJAANPRJIHGJ-UHFFFAOYSA-N
LogP
-1.760
CAS DataBase Reference
60-27-5(CAS DataBase Reference)
NIST Chemistry Reference
Creatinine(60-27-5)
EPA Substance Registry System
4H-Imidazol-4-one, 2-amino-1,5-dihydro-1-methyl- (60-27-5)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
34-36/37/38-20/21/22
Safety Statements 
26-36/37/39-45-24/25-36
RIDADR 
UN 1789 8/PG 3
WGK Germany 
3
F 
9-23
TSCA 
Yes
HS Code 
29332990
Toxicity
A degradation product of creatine. Serum creatinine is elevated after eating meat. High serum creatinine may also be indicative of renal failure.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
NIST914B
Product name
Creatinine
Purity
NIST? SRM? 914b
Packaging
10G
Price
$1600
Updated
2024/03/01
Sigma-Aldrich
Product number
C4255
Product name
Creatinine
Purity
anhydrous, ≥98%
Packaging
1kg
Price
$920
Updated
2024/03/01
Sigma-Aldrich
Product number
1150353
Product name
Creatinine
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
100mg
Price
$474
Updated
2024/03/01
TCI Chemical
Product number
C0398
Product name
Creatinine
Purity
>99.0%(HPLC)(T)
Packaging
25g
Price
$38
Updated
2024/03/01
TCI Chemical
Product number
C0398
Product name
Creatinine
Purity
>99.0%(HPLC)(T)
Packaging
100g
Price
$115
Updated
2024/03/01
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Creatinine Chemical Properties,Usage,Production

Description

Creatinine is together with urea, the most widely known "uremic toxin", and is usually assessed when- ever a reduction in kidney function is suspected. This is mainly because creatinine evaluation is cheap, widely accessible and relatively well reflects the renal function. It also forms the basis for estimation of estimated glomerular filtration rate (eGFR) and thus is a major component of all principal eGFR equations.
Creatinine, which is nonenzymatically produced from the creatine pool in skeletal muscle, but is also to some extent generated from exogenous creatine present in meat, is the major guanidine compound retained in patients with diminished glomerular filtration rate. Creatinine is routinely determined in plasma or serum as a measure of impairment of renal function and it might be expected that a variety of uremic symptoms correlate with the plasma creatinine level; this does not, however, necessarily imply a causal relationship. In fact, high serum creatinine levels correlate with low mortality in HD patients, presumably because the creatinine generation rate reflects the size of the muscle mass. Creatinine seems to be relatively nontoxic. Large amounts of creatinine have been fed to healthy subjects without any adverse effects and animals also tolerate large doses.

Chemical Properties

white powder

Uses

metabolic enhancer

Uses

Creatinine levels in blood and urine may be used to calculate the creatinine clearance (CrCl), which reflects the glomerular filtration rate (GFR), an important clinical index of renal function. It is a substrate for creatininase.

Uses

Creatinine is the end product of creatine catabolism. Creatinine is a normal constituent of urine. Also found together with creatine in muscle tissues and blood. Creatinine is found in all soils and i n grain seeds and other vegetable matter as well as in certain fish and in crab meat extract.

Definition

ChEBI: A lactam obtained by formal cyclocondensation of creatine. It is a metabolite of creatine.

Biological Functions

Creatinine is a byproduct of a chemical compound called creatine, which helps muscles get the energy that they need. As a waste product, creatinine is filtered out of the blood by the kidneys and removed from the body in urine.
A creatinine test measures the amount of this chemical in either the blood or urine. Creatinine levels can provide an indication of how well the kidneys are working.
Creatinine may be measured alone or included in a panel of tests that include other compounds found in the urine or blood.
https://labtestsonline.org/tests/creatinine
https://www.kidney.org/atoz/content/what-creatinine

General Description

Creatinine is a breakdown product formed by the degradation of creatine phosphate from muscles. The kidneys extract creatinine from the body by filtering almost all of it from the blood and excreting it in the urine. Serum creatinine is the most commonly used indicator for renal functioning. In chemical synthesis, creatinine is used as a heterocyclic nitrogenous compound that produces electron-rich and highly basic creatinine derivatives.

Purification Methods

Likely impurities are creatine and ammonium chloride. Dissolve it in dilute HCl, then neutralise with ammonia. Recrystallise it from H2O by adding excess of Me2CO. The picrate crystallises from 23volumes of boiling H2O and has m 220-221o(dec). [King J Chem Soc 2377 1930, Beilstein 25 III/IV 2543.]

Creatinine Preparation Products And Raw materials

Raw materials

Creatine Dichloroacetic acid methyl ester Diisopropylamine ACETIC ACID-DIISOPROPYLAMIDE

Preparation Products

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Creatinine Suppliers

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View Lastest Price from Creatinine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Creatinine 60-27-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98.5%-102.0%
Supply Ability
2000kg
Release date
2022-11-16
Apeloa production Co.,Limited
Product
Creatinine 60-27-5
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
10000
Release date
2024-06-05
Baoji Guokang Bio-Technology Co., Ltd.
Product
Creatinine 60-27-5
Price
US $95.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1 ton
Release date
2021-06-08

60-27-5, CreatinineRelated Search:

6-Aminocaproic acid Trimellitic Anhydride 2-Methyl-4-isothiazolin-3-one Imidazolidine Imidazole 1-Methylimidazole Bensulfuron methyl Dihydromyrcenol Uric acid Succinic anhydride Glycine ISOVALERIC ANHYDRIDE Kresoxim-methyl Chromium(VI) oxide CIS-BUTENEDIOIC ANHYDRIDE 2-Aminoimidazole hemisulfate ALTRENOGEST Methylparaben Kreatinin

  • 2-IMINO-1-METHYLIMIDAZOLIDIN-4-ONE
  • 2-IMINO-N-METHYLHYDANTOIN
  • KREATININ
  • METHYLGUANIDINEACETIC ACID
  • CREATININ
  • CREATININE
  • Diisopropylamine dichloroacetate
  • CREATININE STANDARD 0.01MG/ML
  • CREATININE FREE BASE ANHYDROUSCRYSTALLIN E
  • CREATININE STANDARD 0.1MG/ML
  • CREATININE EXTRA PURE
  • DADA
  • Creatinine,Anhydrous
  • CreatinineGr
  • Diisopropylamini Dichloroacetas
  • Diso-propylamine dichlroacetate
  • Creatinine,98%
  • Dichloroacetic acid, diisopropylammonium salt
  • Diisopropylamine dichloroethanoate
  • Diisopropylammonium dichloroethanoate
  • Creatinine, 99+%
  • Acetic acid, dichloro-, compd. with N-(1-methylethyl)-2-propanamine (1:1)
  • CREATININE NF
  • CREATININE HCL(RG)
  • CREATININE(P)
  • beta-anoxin
  • dichloro-acetic aci compd. with n-(1-methylethyl)-2-propanamine
  • dichloro-acetic acid compd. with diisopropylamine
  • 1-methylhydantoin-2-imide(creatinine)
  • Creatinine anhydrous, >=98%
  • Creatinine, 97+%
  • 1-Methylhydantoine-2-imide
  • 2-amino-3-methyl-1,4-dihydroimidazol-3-ium-5-one
  • 4H-Imidazol-4-one, 2-amino-1,5-dihydro-1-methyl-
  • 4H-Imidazol-4-one, 2-imino-1,5-dihydro-1-methyl-
  • 4H-Imidazol-4-one,2-amino-1,5-dihydro-1-methyl-
  • Methylglycocyamidine
  • 2-amino-1,5-dihydro-1-methyl-4h-imidazol-4-on
  • 2-Imino-1,5-dihydro-1-methyl-4H-imidazol-4-one
  • CREATININE extrapure AR
  • CREATININE extrapure CHR
  • 1-METHYLGLYCOCYAMIDINE
  • 1-METHYLHYDANTOIN-2-IMIDE
  • 2-AMINO-1-METHYL-2-IMIDAZOLIN-4-ONE
  • 2-AMINO-1-METHYL-1,5-DIHYDRO-4H-IMIDAZOL-4-ONE
  • 2-AMINO-1,5-DIHYDRO-1-METHYL-4H-IMIDAZOL-4-ONE
  • 2-Amino-1-methylimidazolidin-4-one
  • 2-IMINO-1-METHYL-4-IMIDAZOLIDINONE
  • 2-Amino-1-methyl-2-imidazolin-4-one, 2-Imino-1-methylimidazolidin-4-one, 2-Imino-N-methylhydantoin
  • Creatinine standard solution
  • 1-Methylhydantoin-2-imid
  • 2-Amino-1-methylimidazolin-4-one
  • Acetic acid, 2,2-dichloro-, compd. with N-(1-methylethyl)-2-propanamine (1:1)
  • Acetic acid, dichloro-, compd. with diisopropylamine (1:1)
  • b-Anoxin
  • Cubisol
  • Dipromonium
  • Vasculopatina