Boc-L-aspartic acid 4-benzyl ester

Product Name: Boc-L-aspartic acid 4-benzyl ester
CAS No.: 7536-58-5
Chemical Name: Boc-L-aspartic acid 4-benzyl ester
Synonyms: BOC-ASP(OBZL)-OH;BOC-ASP(OBZL);(S)-4-(Benzyloxy)-2-((tert-butoxycarbonyl)aMino)-4-oxobutanoic acid;N-BOC-L-ASPARTIC ACID 4-BENZYL ESTER;BOC-L-ASP(OBZL);3oc-Asp(OBzI)-0H;BOC-L-ASP(BZL)-OH;BOC-L-ASP(OBZL)-OH;L-Boc-Asp(OBzl)-OH;D2001Boc-Asp(Obzl)-Oh
CBNumber: CB8673002
Molecular Formula: C16H21NO6
Formula Weight: 323.34
MOL File: 7536-58-5.mol

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Boc-L-aspartic acid 4-benzyl ester Property

Melting point:: 98-102 °C(lit.)
alpha: -20 º (c=2, DMF)
Boiling point:: 461.82°C (rough estimate)
Density: 1.1728 (rough estimate)
refractive index: -20 ° (C=2, DMF)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: almost transparency in N,N-DMF
pka: 3.65±0.23(Predicted)
form: Powder
color: White to off-white
optical activity: [α]20/D 20.0±1°, c = 2% in DMF
BRN: 2064127
InChI: InChI=1S/C16H21NO6/c1-16(2,3)23-15(21)17-12(14(19)20)9-13(18)22-10-11-7-5-4-6-8-11/h4-8,12H,9-10H2,1-3H3,(H,17,21)(H,19,20)/t12-/m0/s1
InChIKey: SOHLZANWVLCPHK-LBPRGKRZSA-N
SMILES: C(O)(=O)[C@H](CC(OCC1=CC=CC=C1)=O)NC(OC(C)(C)C)=O
CAS DataBase Reference: 7536-58-5(CAS DataBase Reference)
EPA Substance Registry System: N-tert-Butoxycarbonyl-L-aspartic acid .beta.-benzyl ester (7536-58-5)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
TSCA: Yes
HS Code: 2924 29 70
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.53045
Product name: Boc-Asp(OBzl)-OH
Purity: Novabiochem?
Packaging: 25g
Price: $49.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.53045
Product name: Boc-Asp(OBzl)-OH
Purity: Novabiochem?
Packaging: 100g
Price: $131
Updated: 2025/07/31

Sigma-Aldrich

Product number: 15386
Product name: Boc-Asp(OBzl)-OH
Purity: ≥99.0% (sum of enantiomers, HPLC)
Packaging: 5g
Price: $43.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 15386
Product name: Boc-Asp(OBzl)-OH
Purity: ≥99.0% (sum of enantiomers, HPLC)
Packaging: 25g
Price: $96.2
Updated: 2023/06/20

TCI Chemical

Product number: B1628
Product name: 4-Benzyl N-(tert-Butoxycarbonyl)-L-aspartate
Purity: >98.0%(T)
Packaging: 5g
Price: $40
Updated: 2025/07/31

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Boc-L-aspartic acid 4-benzyl ester Chemical Properties,Usage,Production

Chemical Properties

white to off-white powder

Uses

N-?[(1,?1-?Dimethylethoxy)?carbonyl]?-?L-?Aspartic acid 4-?(Phenylmethyl) Ester is L-Aspartic Acid (A790024) with side chain and N-terminus protected. L-Aspartic Acid is a non-essential amino acid found in food sources.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

2177-63-1

7536-58-5

The general procedure for the synthesis of (S)-4-(benzyloxy)-2-((tert-butoxycarbonyl)amino)-4-oxobutanoic acid from di-tert-butyl dicarbonate and L-aspartic acid-4-benzyl ester is as follows: in a round-bottomed flask, L-aspartic acid-4-benzyl ester (79.7 g, 357 mmol), sodium bicarbonate (60 g, 714.2 mmol), water (700 mL), and tetrahydrofuran (550 mL). The reaction system was cooled to 0 °C, followed by the slow addition of di-tert-butyl dicarbonate (105 g, 481 mmol) to the reaction vial. After the dropwise addition, the reaction was kept at 0 °C for half an hour, then slowly warmed up to room temperature and continued stirring for 12 hours. After completion of the reaction, tetrahydrofuran was removed by distillation under reduced pressure. The aqueous phase was washed with ethyl acetate (20 mL), followed by adjusting the pH with 10% aqueous citric acid (10 mL) to 1. The aqueous phase was extracted with ethyl acetate (200 mL x 2) and the organic phases were combined. The organic phase was washed sequentially with saturated saline (100 mL × 2) and dried over anhydrous sodium sulfate. After filtration, the solvent was evaporated under reduced pressure to give a white solid product (104 g, 90% yield).

References

[1] Patent: CN106866502, 2017, A. Location in patent: Paragraph 0230-0234
[2] Organic Syntheses, 1985, vol. 63, p. 160 - 160
[3] Tetrahedron Letters, 1991, vol. 32, # 45, p. 6637 - 6640
[4] Asian Journal of Chemistry, 2014, vol. 26, # 19, p. 6541 - 6548
[5] Journal of the American Chemical Society, 2004, vol. 126, # 42, p. 13612 - 13613

Boc-L-aspartic acid 4-benzyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-L-aspartic acid 4-benzyl ester Suppliers

Americas 1 Belgium 1 China 258 Europe 3 France 2 Germany 6 Hungary 1 India 18 Japan 9 Russia 1 Switzerland 5 United Kingdom 13 United States 59 Global 377

ORPEGEN Peptide Chemicals GmbH

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ABCR GmbH & CO. KG

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View Lastest Price from Boc-L-aspartic acid 4-benzyl ester manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Boc-L-aspartic acid 4-benzyl ester 7536-58-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

Hangzhou ICH Biofarm Co., Ltd

Product: Boc-Asp(OBzl)-OH 7536-58-5
Price: US $0.00/Box
Min. Order: 1Box
Purity: 99%
Supply Ability: 200kg
Release date: 2023-06-26

Career Henan Chemical Co

Product: Boc-L-aspartic acid 4-benzyl ester 7536-58-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2018-08-15

7536-58-5, Boc-L-aspartic acid 4-benzyl esterRelated Search:

Benzoyl peroxide Benzyl acetate Benzyl benzoate Benzyl butyrate L-Aspartic acid Benzyl alcohol L-ASPARTIC ACID Benzyl chloride Poly-L-aspartic acid Boc-L-aspartic acid 4-methyl ester AcidEster Benzyl N-ALPHA-T-BOC-L-ASPARTIC ACID BETA-BENZYL ESTER N-HYDROXYSUCCINIMIDE ESTER N-ALPHA-T-BOC-D-ASPARTIC ACID BETA-BENZYL ESTER,BOC-D-ASPARTIC ACID BETA-BENZYL ESTER,BOC-D-ASPARTIC ACID ALPHA-BENZYL ESTER,BOC-D-ASPARTIC ACID 4-BENZYL ESTER Boc-L-aspartic acid 1-benzyl ester L-Aspartic acid 4-benzyl ester Boc-Asp-OH Boc-L-aspartic acid β-benzyl ester N-carboxyanhydride

TBOC-L-ASPARTIC ACID (OBZL)

T-BUTYLOXYCARBONYL-L-ASPARTIC ACID BETA-BENZYL ESTER

N-BOC-L-ASPARTIC ACID 4-BENZYL ESTER

N-ALPHA-TERT-BUTYLOXYCARBONYL-L-ASPARTIC ACID BETA-BENZYL ESTER

N-ALPHA-T-BOC-L-ASPARTIC ACID BETA-BENZYL ESTER

N-ALPHA-T-BOC-L-ASPARTIC-BETA-BENZYL ESTER

N-ALPHA-T-BUTOXYCARBONYL-L-ASPARTIC ACID BETA-BENZYL ESTER

N-T-BUTOXYCARBONYL-L-ASPARTIC ACID BETA-BENZYL ESTER

N-T-BOC-L-ASPARTIC ACID BETA-BENZYL ESTER

N-TERT-BUTOXYCARBONYL-L-ASPARTIC ACID BETA-BENZYL ESTER

N-(TERT-BUTOXYCARBONYL)-L-ASPARTIC ACID 4-BENZYL ESTER

L-Aspartic Acid-15N-β-Benzyl Ester-N-t-BOC

n-tert-butoxycarbonyl-l-aspartic acid á-benzyl ester

BOC-L-ASPARTICCACID4-BENZYLESTER

t-butyloxycarbonylaspartic acid alpha-benzyl ester

n-[(1,1-dimethylethoxy)carbonyl]-l-aspartic acid 4-(phenylmethyl) ester

N-BOC-L-ASPARTIC ACID SS-BENZYL ESTER

N-ALPHA-T-BUTYLOXYCARBONYL-L-ASPARTIC ACID BETA-BENZYL ESTER

NALPHA-tert-Butoxycarbonyl-L-aspartic acid B-benzyl ester

L-Aspartic Acid-N-t-BOC,β-Benzyl Ester-UL-13C4, 15N

Boc-L-aspartic acid 4-benzyl ester, N-(tert-Butoxycarbonyl)-L-aspartic acid 4-benzyl ester

N-Boc-L-aspartic acid ~-benzyl ester, 98%

(2S)-2-(tert-Butoxycarbonylamino)succinic acid 4-benzyl ester

(S)-2-(tert-Butoxycarbonylamino)succinic acid 4-benzyl ester

N-(tert-Butoxycarbonyl)-O-benzyl-4-oxo-L-homoserine

N-(tert-Butyloxycarbonyl)-L-aspartic acid 4-benzyl ester

Na-t-BOC-L-aspartic Acid -Benzyl Ester

Aspartic acid, N-carboxy-, 4-benzyl N-tert-butyl ester, L-

L-Aspartic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 4-(phenylmethyl) ester

N-(tert-Butyloxycarbonyl)-L-aspartic acid b-benzyl ester

N-(tert-Butoxycarbonyl)-L-aspartic acid 4-benzyl ester ,99%

n-[(1,1-dimethylethoxy)carbonyl]-l-asparticaci4-(phenylmethyl)ester

4-BENZYL N-BOC-L-ASPARTATE

4-BENZYL N-(TERT-BUTOXYCARBONYL)-L-ASPARTATE

(2S)-4-(BENZYLOXY)-2-[(TERT-BUTOXYCARBONYL)AMINO]-4-OXOBUTANOIC ACID

BOC-L-ASPARTIC ACID 4-BENZYL ESTER

BOC-L-ASPARTIC ACID B-BENZYL ESTER

BOC-L-ASPARTIC ACID (OBZL)

BOC-L-ASPARTIC ACID BETA-BENZYL ESTER

BOC-L-ASP(BZL)-OH

BOC-L-ASP(OBZL)

BOC-L-ASP(OBZL)-OH

BOC-ASPARTIC ACID(OBZL)-OH

BOC-ASP(OBZL)

BOC-ASP(OBZL)-OH

BOC-ASPARTIC ACID BETA-BENZYL ESTER

BOC-BETA-BENZYLESTER L-ASPARTIC ACID

4-benzyl hydrogen N-(tert-butoxycarbonyl)-L-aspartate

N-Boc-L-aspartic acid b-benzyl ester

D2001Boc-Asp(Obzl)-Oh

N-tert-Butoxycarbonyl-L-aspartic acid beta-benzyl ester,98%

BOC-L-Aspartic acid 4-benzylester, 99+%

L-Aspartic Acid-15N-|beta|-Benzyl Ester-N-t-BOC

L-Aspartic Acid-N-t-BOC,|beta|-Benzyl Ester-UL-13C4, 15N

n-boc-l-aspartic acid á-benzyl ester

L-ASPARTIC ACID-N-FMOC

L-ASPARTIC ACID-N-T-BOC, B-BZ ESTER

L-ASPARTIC ACID-N-T-BOC, BETA-BZ ESTER