CIRAZOLINE HYDROCHLORIDE
- Product Name
- CIRAZOLINE HYDROCHLORIDE
- CAS No.
- 40600-13-3
- Chemical Name
- CIRAZOLINE HYDROCHLORIDE
- Synonyms
- LD-3098;Cirazoline hydrochlo;LD 3098 hydrochloride;CIRAZOLINE HYDROCHLORIDE;CIRAZOLINE HYDROCHLORIDE SELECTIVE A1 AD RENOCE;2-(2-CYCLOPROPYLPHENOXYMETHYL)IMIDAZOLINE HYDROCHLORIDE;2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazolium chloride;2-[(2-CYCLOPROPYLPHENOXY)METHYL]-4,5-DIHYDRO-1H-IMIDAZOLE HYDROCHLORIDE
- CBNumber
- CB8676982
- Molecular Formula
- C13H17ClN2O
- Formula Weight
- 252.74
- MOL File
- 40600-13-3.mol
CIRAZOLINE HYDROCHLORIDE Property
- storage temp.
- Store at RT
- solubility
- H2O: >35 mg/mL
- form
- solid
- color
- white
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- C223
- Product name
- Cirazoline hydrochloride
- Purity
- solid
- Packaging
- 10mg
- Price
- $152
- Updated
- 2024/03/01
- Product number
- 21791
- Product name
- Cirazoline (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $85
- Updated
- 2024/03/01
- Product number
- 21791
- Product name
- Cirazoline (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $128
- Updated
- 2024/03/01
- Product number
- 21791
- Product name
- Cirazoline (hydrochloride)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $296
- Updated
- 2024/03/01
- Product number
- C497403
- Product name
- Cirazoline hydrochloride
- Packaging
- 2.5mg
- Price
- $165
- Updated
- 2021/12/16
CIRAZOLINE HYDROCHLORIDE Chemical Properties,Usage,Production
Description
Cirazoline is an α1-adrenergic receptor (α1-AR) agonist (Kis = 120, 960, and 660 nM for recombinant α1A-, α1B-, and α1D-ARs, respectively, in CHO cell membranes). It acts as a full agonist at α1A- and a partial agonist at α1B- and α1D-ARs in vitro (EC50s = 70.7, 79.4, and 239.8 nM, respectively). It also acts as an antagonist at α2-ARs with a pA2 value of 7.56 to inhibit the norepinephrine-induced twitch response in isolated pig ileum. Cirazoline (0.01-1 μg/kg) decreases blood pressure when administered via microinjection to the nucleus reticularis lateralis (NRL) of anesthetized normotensive cats. It enhances spatial memory and reduces depressive- and anxiety-like behavior in mice when administered at a concentration of 10 mg/L in drinking water for 2-9 months. It also enhances performance in the variable delayed response task in aged rhesus monkeys at high doses of 1-10 μg/kg but impairs performance at lower doses of 0.01-1 μg/kg.
Uses
Cirazoline hydrochloride has been used to activate the α1-noradrenergic receptors and to study the inhibitory effect of neurokinin1 (NK1) antagonists on respiratory activity using the brainstem transverse slice.
Biological Activity
Selective α 1 agonist. Also available as part of the α 1 -Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™ .
Biochem/physiol Actions
Cirazoline is a selective α1-adrenoceptor agonist and also a non-selective ligand for the imidazoline binding site. Cirazoline dereases spatial working memory performance in aged monkeys.
storage
Store at RT
CIRAZOLINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
CIRAZOLINE HYDROCHLORIDE Suppliers
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