3-DEAZAADENOSINE
- Product Name
- 3-DEAZAADENOSINE
- CAS No.
- 6736-58-9
- Chemical Name
- 3-DEAZAADENOSINE
- Synonyms
- C3-Ado;3-Deaza-rA;NSC 167897;3-DEAZAADENOSINE;3-Deaza-D-adenosine;3-Deazaadenosine ,98%;3-DEAZAADENOSINE USP/EP/BP;1-β-D-Ribofuranosyl-1H-imidazo[4,5-c]pyridin-4-amine;4-Amino-1-(D-ribofuranosyl)-1H-imidazo(4,5)-pyridine;1H-Imidazo[4,5-c]pyridin-4-amine,1-b-D-ribofuranosyl-
- CBNumber
- CB8680473
- Molecular Formula
- C11H14N4O4
- Formula Weight
- 266.25
- MOL File
- 6736-58-9.mol
3-DEAZAADENOSINE Property
- Melting point:
- 228-229°C
- Boiling point:
- 665.7±65.0 °C(Predicted)
- Density
- 1.90±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- H2O: 10 mg/mL with heating to 60 °C
- pka
- 13.24±0.70(Predicted)
- form
- Solid
- color
- White to Off-White
Safety
- Safety Statements
- 24/25
- RIDADR
- 2811
- WGK Germany
- 3
- HazardClass
- 6.1(a)
- PackingGroup
- II
- HS Code
- 29419090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P311Call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- D8296
- Product name
- 3-Deazaadenosine
- Packaging
- 5mg
- Price
- $341
- Updated
- 2024/03/01
- Product number
- D8296
- Product name
- 3-Deazaadenosine
- Packaging
- 10mg
- Price
- $614
- Updated
- 2024/03/01
- Product number
- 9000785
- Product name
- 3-Deazaadenosine
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $50
- Updated
- 2024/03/01
- Product number
- 9000785
- Product name
- 3-Deazaadenosine
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $220
- Updated
- 2024/03/01
- Product number
- 9000785
- Product name
- 3-Deazaadenosine
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $389
- Updated
- 2024/03/01
3-DEAZAADENOSINE Chemical Properties,Usage,Production
Description
3-Deazaadenosine (3-DZA) is an inhibitor of SAH (Sadenosylhomocysteine) hydrolase (Ki = 3.9 μM). It has antiinflammatory properties, inhibiting leukocyte adhesion and chemotaxis, lymphocyte-mediated cytolysis, phagocytosis, degranulation, and NF-κB signaling. 3-DZA also has anti-viral and anti-bacterial activities.
Chemical Properties
Bright Yellow Solid
Uses
Possesses antiviral activity. It is an inhibitor of leukocyte adhesion to TNF-treated endothelial cells.
Biochem/physiol Actions
Possesses antiviral activity inhibitor of leukocyte adhesion to TNF-treated endothelial cells.
in vitro
3-deazaadenosine showed inhibitory values against the ebo-z viruses, ebo, and marburg virus in various cell lines of primate (sw13, vero 76, frhl, llc-mk2, mrc-5, vero e6) and mouse (balb/3t3 clone a31) origin. 3-deazaadenosine at 2 μg/ml could reduce viral replication by 3 logs in a dose-dependent manner. however, there was no further inhibition even with a 100-fold increase in concentration [1].
in vivo
in vehicle control group, adult balb/c mice lethally infected with mouse-adapted ebola virus die 5-7 days after infection. in contrast, 3-deazaadenosine treatment initiated on day 0 or 1 led to a dose-dependent protection, with mortality completely prevented at doses around 0.7 mg/kg every 8 h. moreover, there was significant protection when 3-deazaadenosine treatment was begun on day 2, at which time, the spleen had an average titer of 2 × 106 pfu/g and the liver had 3 × 105 pfu/g virus. treatment with 3-aeazaadenosine at 2.2 mg/kg initiated on day 3 resulted in 40% survival [1].
References
[1] huggins, z. x. zhang and m. bray. antiretroviral drug therapy of filovirus infections: s-adenosylhomocysteine hydrolase inhibitors inhibit ebola virus in vitro and in a lethal mouse model. journal of infectious diseases 179 (1), s240-s247 (1999).
3-DEAZAADENOSINE Preparation Products And Raw materials
Raw materials
Preparation Products
3-DEAZAADENOSINE Suppliers
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View Lastest Price from 3-DEAZAADENOSINE manufacturers
- Product
- 3-DEAZAADENOSINE 6736-58-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-26
- Product
- 3-DEAZAADENOSINE 6736-58-9
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 500g;1kg； 25kg
- Release date
- 2020-01-09