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3-DEAZAADENOSINE

Product Name
3-DEAZAADENOSINE
CAS No.
6736-58-9
Chemical Name
3-DEAZAADENOSINE
Synonyms
C3-Ado;3-Deaza-rA;NSC 167897;3-DEAZAADENOSINE;3-Deaza-D-adenosine;3-Deazaadenosine ,98%;3-DEAZAADENOSINE USP/EP/BP;1-β-D-Ribofuranosyl-1H-imidazo[4,5-c]pyridin-4-amine;4-Amino-1-(D-ribofuranosyl)-1H-imidazo(4,5)-pyridine;1H-Imidazo[4,5-c]pyridin-4-amine,1-b-D-ribofuranosyl-
CBNumber
CB8680473
Molecular Formula
C11H14N4O4
Formula Weight
266.25
MOL File
6736-58-9.mol
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3-DEAZAADENOSINE Property

Melting point:
228-229°C
Boiling point:
665.7±65.0 °C(Predicted)
Density 
1.90±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
H2O: 10 mg/mL with heating to 60 °C
pka
13.24±0.70(Predicted)
form 
Solid
color 
White to Off-White
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Safety

Safety Statements 
24/25
RIDADR 
2811
WGK Germany 
3
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
29419090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P311Call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D8296
Product name
3-Deazaadenosine
Packaging
5mg
Price
$341
Updated
2024/03/01
Sigma-Aldrich
Product number
D8296
Product name
3-Deazaadenosine
Packaging
10mg
Price
$614
Updated
2024/03/01
Cayman Chemical
Product number
9000785
Product name
3-Deazaadenosine
Purity
≥98%
Packaging
1mg
Price
$50
Updated
2024/03/01
Cayman Chemical
Product number
9000785
Product name
3-Deazaadenosine
Purity
≥98%
Packaging
5mg
Price
$220
Updated
2024/03/01
Cayman Chemical
Product number
9000785
Product name
3-Deazaadenosine
Purity
≥98%
Packaging
10mg
Price
$389
Updated
2024/03/01
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3-DEAZAADENOSINE Chemical Properties,Usage,Production

Description

3-Deazaadenosine (3-DZA) is an inhibitor of SAH (Sadenosylhomocysteine) hydrolase (Ki = 3.9 μM). It has antiinflammatory properties, inhibiting leukocyte adhesion and chemotaxis, lymphocyte-mediated cytolysis, phagocytosis, degranulation, and NF-κB signaling. 3-DZA also has anti-viral and anti-bacterial activities.

Chemical Properties

Bright Yellow Solid

Uses

Possesses antiviral activity. It is an inhibitor of leukocyte adhesion to TNF-treated endothelial cells.

Biochem/physiol Actions

Possesses antiviral activity inhibitor of leukocyte adhesion to TNF-treated endothelial cells.

in vitro

3-deazaadenosine showed inhibitory values against the ebo-z viruses, ebo, and marburg virus in various cell lines of primate (sw13, vero 76, frhl, llc-mk2, mrc-5, vero e6) and mouse (balb/3t3 clone a31) origin. 3-deazaadenosine at 2 μg/ml could reduce viral replication by 3 logs in a dose-dependent manner. however, there was no further inhibition even with a 100-fold increase in concentration [1].

in vivo

in vehicle control group, adult balb/c mice lethally infected with mouse-adapted ebola virus die 5-7 days after infection. in contrast, 3-deazaadenosine treatment initiated on day 0 or 1 led to a dose-dependent protection, with mortality completely prevented at doses around 0.7 mg/kg every 8 h. moreover, there was significant protection when 3-deazaadenosine treatment was begun on day 2, at which time, the spleen had an average titer of 2 × 106 pfu/g and the liver had 3 × 105 pfu/g virus. treatment with 3-aeazaadenosine at 2.2 mg/kg initiated on day 3 resulted in 40% survival [1].

References

[1] huggins, z. x. zhang and m. bray. antiretroviral drug therapy of filovirus infections: s-adenosylhomocysteine hydrolase inhibitors inhibit ebola virus in vitro and in a lethal mouse model. journal of infectious diseases 179 (1), s240-s247 (1999).

3-DEAZAADENOSINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-DEAZAADENOSINE Suppliers

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View Lastest Price from 3-DEAZAADENOSINE manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
3-DEAZAADENOSINE 6736-58-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-26
Career Henan Chemical Co
Product
3-DEAZAADENOSINE 6736-58-9
Price
US $0.01/KG
Min. Order
1KG
Purity
98%; 99%
Supply Ability
500g;1kg； 25kg
Release date
2020-01-09

6736-58-9, 3-DEAZAADENOSINERelated Search:

8-AZA-9-DEAZAADENOSINE MONOHYDRATE 7-DEAZAADENOSINE-7-CARBOXAMIDE 7-DEAZAADENOSINE 7-DEAZAADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT,7-deazaadenosine-3’,5’-cyclicmonophosphate(7-ch-camp),sodiumsal 7-IODO-2',3'-DIDEOXY-7-DEAZAADENOSINE carbocyclic 3-deazaadenosine 7-IODO-7-DEAZAADENOSINE,7-Iodo-7-deazaadenosine, 4-Amino-5-iodo-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine 2-AMINO-6-METHOXY-2'-DEOXY-7-DEAZAADENOSINE 3-DEAZAADENOSINE, [8-3H] 3-DEAZAADENOSINE 7-DEAZAADENOSINE-5'-O-MONOPHOSPHATE SODIUM SALT,7-deazaadenosine-5’-monophosphate(7-ch-5’-amp/tump),sodiumsal 1-deazaadenosine 5'-methylthio-5'-deoxy-9-deazaadenosine 4-AMINO-6-CHLORO-1-B-D-RIBOFURANOSYLIMIDAZO[4,5-C]PYRIDINE 3-DEAZA-CADP-RIBOSE 7-DEAZAADENOSINE, [3H]- 9-deazaadenosine triphosphate 3-Deazaadenosine 5'-triphosphate

  • 3-DEAZAADENOSINE
  • 4-AMINO-1-[BETA-D-RIBOFURANOSYL]-1H-IMIDAZO[4,5]-PYRIDINE
  • 4-Amino-1-(D-ribofuranosyl)-1H-imidazo(4,5)-pyridine
  • 1H-Imidazo4,5-cpyridin-4-amine, 1-.beta.-D-ribofuranosyl-
  • 3-Deaza-D-adenosine
  • NSC 167897
  • (2R,3R,4S,5R)-2-(4-AMino-1H-iMidazo[4,5-c]pyridin-1-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol
  • 3-Deaza-rA
  • 1-β-D-Ribofuranosyl-1H-imidazo[4,5-c]pyridin-4-amine
  • C3-Ado
  • 3-Deazaadenosine ,98%
  • 4-Amino-1-beta-D-ribofuranosyl-1H-imidazo[4,5-c]pyridine
  • 1H-Imidazo[4,5-c]pyridin-4-amine, 1-β-D-ribofuranosyl-
  • 1H-Imidazo[4,5-c]pyridin-4-amine,1-b-D-ribofuranosyl-
  • 3-DEAZAADENOSINE USP/EP/BP
  • 6736-58-9
  • Immune Cell Signaling and Blood
  • Immune System Regulation
  • AIDS and Viral Research Reagents
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Bases & Related Reagents
  • Inhibitors
  • Nucleotides